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Product Code B1701-5g
Price $213 ex. VAT

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A fluorinated indole

Used as a synthesis intermediate for APIs, dyes and polyindoles in application of drug discovery, OLEDs, DSSCs and batteries


7-Fluoroindole (CAS number 387-44-0) is a fluorinated heterocyclic compound derived from indole, a benzene fused pyrrole. 7-Fluoroindole has proven effective on supressing swarming motility, protease activity and the production of a polymeric matrix in Pseudomonas aeruginosa, an opportunistic human pathogen. The anti-virulence of 7-fluoroindole is based on decreasing the production of quorum sensing related phenotypes. 7-Fluoroindole is also used in 19F NMR study on the binding affinity to R67 dihydrofolate reductase (an enzyme confers resistance to antibacterial drug trimethoprim).

7-Fluoroindole can be used to synthesize polyindole by oxidative polymerization. Polyindole is a conducting polymer that has been applied in batteries (polyindole/LiClO4/Li with discharge capacity of 116–124 mAh/g at current density of 0.5 A/m2).

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated building block

Fluorinated indole building block

For drug discovery, OLEDs, and batteries

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High purity 387-44-0

High purity

>98% High purity

General Information

CAS Number 387-44-0
Chemical Formula C8H6FN
Full Name 7-Fluoro-1H-indole
Molecular Weight 135.14 g/mol
Synonyms N/A
Classification / Family Fluorinated building block, Heterocyclic building block, APIs, Batteries, OLEDs, DSSCs

Chemical Structure

7-Fluoroindole chemical structure, CAS 387-44-0
7-Fluoroindole chemical structure, CAS 387-44-0

Product Details

Purity 98%
Melting Point Tm = 60 °C – 65 °C
Appearance Off-white powder

MSDS Documentation

7-Fluoroindole7-Fluoroindole MSDS Sheet

Literature and Reviews

  1. 7-fluoroindole as an antivirulence compound against Pseudomonas aeruginosa, J.-H. Lee et al., FEMS Microbiol. Lett., 329, 36–44(2012); DOI: 10.1111/j.1574-6968.2012.02500.x.
  2. Differentiation of the binding of two ligands to a tetrameric protein with a single symmetric active site by 19F NMR, G. Fuente-Gómez et al., Protein Science, 30, 477–484(2021); DOI: 10.1002/pro.4007.
  3. Mixed fluorotryptophan substitution at the same residue expand the versatility of 19F protein NMR spectroscopy, C. Kenward etal., Chem. Eur. J., 24, 3391–3396(2018); DOI: 10.1002/chem.201705638.
  4. Polyindole batteries and supercapacitors, I. Marriam et al., Energy Storage Mater., 33, 336–359(2020); DOI: 10.1016/j.ensm.2020.08.010.
  5. Small molecule control of bacterial biofilms, R. Worthington et al., Org Biomol Chem., 10(37), 7457–7474(2012); DOI: 10.1039/c2ob25835h.

To the best of our knowledge the information provided here is accurate. The values provided are typical at the time of manufacture and may vary over time and from batch to batch. Products may have minor cosmetic differences (e.g. to the branding) compared to the photos on our website. All products are for laboratory and research and development use only.

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