7-Fluoroindole

CAS Number 387-44-0

Chemistry Building Blocks, Fluorinated Building Blocks, Heterocyclic Building Blocks, Monomers

A fluorinated indole

Used as a synthesis intermediate for APIs, dyes and polyindoles in application of drug discovery, OLEDs, DSSCs and batteries

Overview
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7-Fluoroindole (CAS number 387-44-0) is a fluorinated heterocyclic compound derived from indole, a benzene fused pyrrole. 7-Fluoroindole has proven effective on supressing swarming motility, protease activity and the production of a polymeric matrix in Pseudomonas aeruginosa, an opportunistic human pathogen. The anti-virulence of 7-fluoroindole is based on decreasing the production of quorum sensing related phenotypes. 7-Fluoroindole is also used in ¹⁹F NMR study on the binding affinity to R67 dihydrofolate reductase (an enzyme confers resistance to antibacterial drug trimethoprim).

7-Fluoroindole can be used to synthesize polyindole by oxidative polymerization. Polyindole is a conducting polymer that has been applied in batteries (polyindole/LiClO4/Li with discharge capacity of 116–124 mAh/g at current density of 0.5 A/m²).

Multiple functional groups

For facile synthesis

Fluorinated indole building block

For drug discovery, OLEDs, and batteries

Worldwide shipping

Quick and reliable shipping

High purity

>98% High purity

General Information

CAS Number	387-44-0
Chemical Formula	C₈H₆FN
Full Name	7-Fluoro-1H-indole
Molecular Weight	135.14 g/mol
Synonyms	N/A
Classification / Family	Fluorinated building block, Heterocyclic building block, APIs, Batteries, OLEDs, DSSCs

Chemical Structure

Product Details

Purity	98%
Melting Point	T_m = 60 °C – 65 °C
Appearance	Off-white powder

MSDS Documentation

7-Fluoroindole MSDS Sheet

Literature and Reviews

7-fluoroindole as an antivirulence compound against Pseudomonas aeruginosa, J.-H. Lee et al., FEMS Microbiol. Lett., 329, 36–44(2012); DOI: 10.1111/j.1574-6968.2012.02500.x.
Differentiation of the binding of two ligands to a tetrameric protein with a single symmetric active site by ¹⁹F NMR, G. Fuente-Gómez et al., Protein Science, 30, 477–484(2021); DOI: 10.1002/pro.4007.
Mixed fluorotryptophan substitution at the same residue expand the versatility of ¹⁹F protein NMR spectroscopy, C. Kenward etal., Chem. Eur. J., 24, 3391–3396(2018); DOI: 10.1002/chem.201705638.
Polyindole batteries and supercapacitors, I. Marriam et al., Energy Storage Mater., 33, 336–359(2020); DOI: 10.1016/j.ensm.2020.08.010.
Small molecule control of bacterial biofilms, R. Worthington et al., Org Biomol Chem., 10(37), 7457–7474(2012); DOI: 10.1039/c2ob25835h.

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