2,4-Difluorobenzonitrile
CAS Number 3939-09-1
Chemistry Building Blocks, Fluorinated Building Blocks, Materials, MonomersA fluorinated benzonitrile building block
Used in synthesizing ligands for OLEDs, photoredox catalysts and APIs
Specifications | MSDS | Literature and Reviews
2,4-Difluorobenzonitrile (CAS number 3939-09-1) is a benzonitrile derivative with two fluorine atoms at 2- and 4-positions. 2,4-Difluorobenzonitrile is commonly used as a molecular building block for introducing fluorinated benzonitrile to the target molecules by nucleophilic aromatic substitution. The reactive side is primarily on the para-position to the nitrile group, as it is less sterically hindered. 2,4-Difluorobenzonitrile functionalised triazolopyrimidine has been comprehensively studied on treatment of Alzheimer's disease.
2,4-Difluorobenzonitrile reacts with sodium azide for fluorinated tetrazole, a 5-membered ring heterocyclic with four nitrogen atoms. Fluorinated phenyltetrazole forms complexes with iridium showing blue light photoluminescence quantum yield up to 76%. The complexes are promising to be used in OLEDs and photoredox catalytic reactions.
Multiple functional groups
For facile synthesis
Fluorinated benzonitrile building block
For drug discovery, photoredox catalysts, OLEDs research
Worldwide shipping
Quick and reliable shipping
High purity
>98% High purity
General Information
CAS Number | 3939-09-1 |
Chemical Formula | C7H3F2N |
Full Name | 2,4-Difluorobenzonitrile |
Molecular Weight | 139.10 g/mol |
Synonyms | N/A |
Classification / Family | Fluorinated building block, Ligands, OLEDs, APIs, Photoredox catalysts |
Chemical Structure
Product Details
Purity | 98% |
Melting Point | Tm = 47 – 49 °C |
Appearance | White to off-white solid |
MSDS Documentation
2,4-Difluorobenzonitrile MSDS Sheet
Literature and Reviews
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Evaluation of structure-activity relationship of microtubule(MT)-targeting 1,2,4-triazolo[1,5-a]pyrimidines identifies new candidates for neurodegenerative tauopathies, K. Oukoloff et al., J. Med. Chem., 64(2), 1073–1102(2021); DOI: 10.1021/acs.jmedchem.0c01605.
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Iridium(III) complexes with fluorinated phenyl-tetrazoles as cyclometalating ligands: enhanced excited-state energy and blue emission, A. Baschieri et al., Inorg. Chem., 59(22), 16238–16250(2020); DOI: 10.1021/acs.inorgchem.0c01995.
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Measuring the microphase separation scale of polyurethanes with a vibration-induced emission-based ratiometric 'fluorescent ruler', ACS Appl. Mater. Interfaces, 11, 39351–39358(2019); DOI: 10.1021/acsami.9b13193.