5-Fluorosalicylic acid

CAS Number 345-16-4

Chemistry Building Blocks, Fluorinated Building Blocks, Monomers, Non-Heterocyclic Building Blocks

A fluorinated salicylic acid building block

A metal chelating agent and building block for fluorescence immunoassay, pH sensors and APIs

Overview
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5-Fluorosalicylic acid (CAS number 345-16-4), also known as 5-fluoro-2-hydroxybenzoic acid, has a fluorine substituent at 5-position and a hydroxyl group at 2-position. As an ortho-hydroxybenzoic acid, 5-fluorosalicylic acid is a good chelating agent. It forms highly fluorescent ternary complexes with terbium (Tb³⁺) that are employed in immunoassay. 5-Fluorosalicylic acid binds to copper (Cu²⁺) generating three isomers. Each isomer is formed predominantly depending on the pH value. Thus, 5-fluorosalicylic acid-copper complexes can be used for pH sensors. A flexible trifurcate titanium with 5-fluorosalicylic acid metalloligand can encapsulate silver nanoclusters in tetrahedral geometry. The metalloligand induces spatial growth and stability to the nanoclusters in non-linear optical and photoluminescent applications.

5-Fluorosalicylic acid is also used as a building block for active pharmaceutical ingredients (APIs) such as fluorinated deferasirox for chronic iron overload.

Multiple functional groups

For facile synthesis

Fluorinated salicylic acid building block

For drug discovery, metal complexes and dyes

Worldwide shipping

Quick and reliable shipping

High purity

>98% High purity

General Information

CAS Number	345-16-4
Chemical Formula	C₇H₅FO₃
Full Name	5-Fluorosalicylic acid
Molecular Weight	156.11 g/mol
Synonyms	5-Fluoro-2-hydroxybenzoic acid, 2-Hydroxy-5-fluorobenzoic acid
Classification / Family	Fluorinated building block, Ligands, Fluorescence immunoassay, APIs, Sensors

Chemical Structure

Product Details

Purity	98%
Melting Point	T_m = 177 – 179 °C
Appearance	Pale beige powder

MSDS Documentation

5-Fluorosalicylic acid MSDS Sheet

Literature and Reviews

Complexation of 5-fluorosalicylic acid with copper(II): a pH-potentiometric, UV–vis spectroscopic, and electron spin resonance study by the two-dimensional simulation of spectra, T. Szabó-Plánka et al., J. Inorg. Biochem., 102, 101–109 (2008); DOI: 10.1016/j.jinorgbio.2007.07.019.
Enzymatically amplified time-resolved fluorescence immunoassay with terbium chelates, T. Christopoulos et al., Anal. Chem., 64(4), 342–346(1992); DOI: 10.1021/ac00028a004.
Tetrahedral geometry induction of stable Ag-Ti nanoclusters by flexible trifurcate TiL₃ metalloligand, M.-Y. Gao et al., J. Am. Chem. Soc., 142(29), 12784–12790(2020); DOI: 10.1021/jacs.0c05199.
The clinically used ion chelator deferasirox is an inhibitor of epigenetic JumonjiC domain containing histone demethylases, M. Roatsch et al., ACS Chem. Biol., 14(8), 1737–1750(2019); DOI: 10.1021/acschembio.9b00289.

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