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Product Code B1581-10g
Price £120 ex. VAT

A fluorinated heterocyclic building block

Used as a synthesis intermediate for enzyme inhibitors and dye-sensitized solar cells (DSSCs)

Specifications | MSDS | Literature and Reviews

6-Fluoro-4-chromanone (CAS number 66892-34-0) is a fluorinated heterocyclic compound that is a benzene-fused dihydropyran with a fluorine and a ketone substituent. The fluorine group enhances the lipophilicity of 6-fluoro-4-chromanone, and also favours further functionalization via nucleophilic aromatic substitution. Through this method, chromophoric xerogels are synthesized for sensor applications. The ketone substituent supports functionalization through an aldol reaction. 6-Fluoro-4-chromanone is also used as an enzyme inhibitor such as Sirtuin 2 (an enzyme related to aging diseases).

6-Fluoro-4-chromanone can be fully aromatized in an oxidation reaction catalysed by iodine, to expand its application to DSSCs.

Multiple functional groups

Multiple functional groups

For facile synthesis

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High purity 66892-34-0

High purity

>99% High purity

Fluorinated building block

Fluorinated chromanone building block

For semiconductors, dyes, and solar cells

General Information

CAS Number 66892-34-0
Chemical Formula C9H7FO2
Full Name 6-Fluoro-2,3-dihydro-4H-chromen-4-one
Molecular Weight 166.15 g/mol
Synonyms 6-Fluorochroman-4-one
Classification / Family Dyes, Semiconductor synthesis intermediates, organic photovoltaics

Chemical Structure

6-Fluoro-4-chromanone chemical structure, CAS 66892-34-0
6-Fluoro-4-chromanone chemical structure, CAS 66892-34-0

Product Details

Purity 99%
Boiling Point Tm = 114 °C – 116 °C
Appearance Off-white powder

MSDS Documentation

6-Fluoro-4-chromanone6-Fluoro-4-chromanone MSDS Sheet

Literature and Reviews

  1. A one-pot synthesis of chromophoric silicate-based xerogels, S. Spange et al., Angew. Chem. Int. Ed., 41, 1729-1732(2002); DOI: 10.1002/1521-3773(20020517)41:10<1729::AID-ANIE1729>3.0.CO;2-V.
  2. Efficient synthesis of chromones with alkenyl functionalities by the Heck reaction, T. Patonay et al., Aust. J. Chem., 63, 1582–1593(2010); DOI:10.1071/CH10295.
  3. Eploration of chromone-based thiosemicarbazone derivatives: SC-XRD/DFT, spectral (IR, UV−Vis) characterization, and quantum chemical analysis, R. Basri et al., ACS Omega, 5, 30176-30188(2020); DOI: 10.1021/acsomega.0c04653.

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