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Product Code B1581-10g
Price $150 ex. VAT

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A fluorinated heterocyclic building block

Used as a synthesis intermediate for enzyme inhibitors and dye-sensitized solar cells (DSSCs)


6-Fluoro-4-chromanone, CAS number 66892-34-0, is a fluorinated heterocyclic compound that is a benzene-fused dihydropyran with a fluorine and a ketone substituent. The fluorine group enhances the lipophilicity of 6-fluoro-4-chromanone, and also favours further functionalization via nucleophilic aromatic substitution. Through this method, chromophoric xerogels are synthesized for sensor applications. The ketone substituent supports functionalization through an aldol reaction. 6-Fluoro-4-chromanone is also used as an enzyme inhibitor such as Sirtuin 2 (an enzyme related to aging diseases).

6-Fluoro-4-chromanone can be fully aromatized in an oxidation reaction catalysed by iodine, to expand its application to DSSCs.

Multiple functional groups

Multiple functional groups

For facile synthesis

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High purity 66892-34-0

High purity

>99% High purity

Fluorinated building block

Fluorinated chromanone building block

For semiconductors, dyes, and solar cells

General Information

CAS Number 66892-34-0
Chemical Formula C9H7FO2
Full Name 6-Fluoro-2,3-dihydro-4H-chromen-4-one
Molecular Weight 166.15 g/mol
Synonyms 6-Fluorochroman-4-one
Classification / Family Dyes, Semiconductor synthesis intermediates, organic photovoltaics

Chemical Structure

6-Fluoro-4-chromanone chemical structure, CAS 66892-34-0
6-Fluoro-4-chromanone chemical structure, CAS 66892-34-0

Product Details

Purity 99%
Boiling Point Tm = 114 °C – 116 °C
Appearance Off-white powder

MSDS Documentation

6-Fluoro-4-chromanone6-Fluoro-4-chromanone MSDS Sheet

Literature and Reviews

  1. A one-pot synthesis of chromophoric silicate-based xerogels, S. Spange et al., Angew. Chem. Int. Ed., 41, 1729-1732(2002); DOI: 10.1002/1521-3773(20020517)41:10<1729::AID-ANIE1729>3.0.CO;2-V.
  2. Efficient synthesis of chromones with alkenyl functionalities by the Heck reaction, T. Patonay et al., Aust. J. Chem., 63, 1582–1593(2010); DOI:10.1071/CH10295.
  3. Eploration of chromone-based thiosemicarbazone derivatives: SC-XRD/DFT, spectral (IR, UV−Vis) characterization, and quantum chemical analysis, R. Basri et al., ACS Omega, 5, 30176-30188(2020); DOI: 10.1021/acsomega.0c04653.
  4. Preparation of a 2-(4-fluorophenyl)indole-modified xerogel and its use for the fabrication of screen-printed electrodes for the electrocatalytic determination of sulfide, G. Roman et al., Anal. Chim. Acta, 523, 201-207(2004); DOI: 10.1016/j.aca.2004.07.037.
  5. Synthesis and evaluation of substituted chroman-4-one and chromone derivatives as sirtuin 2‑selective inhibitors, M. Fridén-Saxin et al., J. Med. Chem. 55, 7104-7113(2012); DOI: 10.1021/jm3005288.

To the best of our knowledge the information provided here is accurate. The values provided are typical at the time of manufacture and may vary over time and from batch to batch. Products may have minor cosmetic differences (e.g. to the branding) compared to the photos on our website. All products are for laboratory and research and development use only.

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