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Product Code B2291-1g
Price £90 ex. VAT

A fluorinated adenine

Strong biological interaction for anti-cancer, fluorine probe and hydrogels


Specifications | MSDS | Literature and Reviews


2-Fluoroadenine (CAS number 700-49-2) is a fluorinated heterocyclic aromatic compound consisting of fused pyrimidine and imidazole rings. Adenine is one of the four nucleobases in the nucleic acids of deoxyribonucleic acid (DNA). Adenine derivatives, such as adenosine triphosphate (ATP), are vital organic compounds in human body. In recent anti-cancer study, 2-fluoroadenine acts as a radiosensitizer that damages the DNA in cancerous cells under low energy electron (20 eV) radiation. As a fluorinated compound, 2-fluoroadenine has been used as a fluorine probe in 19F NMR for studying the conformational exchange in neomycin sensing riboswitch.

A thermoreversible hydrogel is prepared from adenine and 1,3,5-tris(4-carboxyphenyl)benzene in water. The hydrogel can capture dyes like methylene blue, rhodamine 6G and crystal violet in application of water purification.

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated building block

Fluorinated adenin building block

For drug discovery, NMR probe and hydrogels

Worldwide shipping for 700-49-2

Worldwide shipping

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High purity 700-49-2

High purity

>97% High purity

General Information


CAS Number 700-49-2
Chemical Formula C5H4FN5
Full Name 2-Fluoroadenine
Molecular Weight 153.12 g/mol
Synonyms 2-Fluoro-7H-purin-6-amine, 2-Fluoro-6-aminopurine
Classification / Family Fluorinated building block, Heterocyclic building block, APIs, Radoisensitizers, Hydrogels

Chemical Structure


2-Fluoroadenine chemical structure, CAS 700-49-2
2-Fluoroadenine chemical structure, CAS 700-49-2

Product Details


Purity 97%
Melting Point Tm > 350 °C
Appearance White powder

MSDS Documentation


2-Fluoroadenine2-Fluoroadenine MSDS Sheet

Literature and Reviews


  1. Multi-site conformational exchange in the synthetic neomycin-sensing riboswitch studies by 19F NMR, J. Overbeck et al., Angew. Chem. Int. Ed., 2023, 62, e202218064, DOI: 10.1002/anie.202218064.
  2. Evaluating antitumor activity of Escherichia coli purine nucleoside phosphorylase against head and neck patient-derived xenografts, R. Rab et al., Cancer Rep., 6(2), e1708(2023); DOI: 10.1002/cnr2.1708.
  3. Lab-on-a-DNA origami: nanoengineered single-molecule platforms, S. Kogikoski et al., Chem. Commum., 59, 4726(2023); DOI: 10.1039/d3cc00718a.
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