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4-(Trifluoromethyl)-2-pyridone CAS 50650-59-4
Product Code B1481-1g
Price £72 ex. VAT
£ GBP

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A highly electron deficient pyridone derivative

Used as building block for the synthesis of key intermediates in the production of pharmaceuticals and drug discovery

Specifications | MSDS | Literature and Reviews


4-(Trifluoromethyl)-2-pyridone (CAS number 50650-59-4), also known as 2-hydroxy-4-(trifluoromethyl)pyridine, bears the structure of 2-pyridone with an electron deficient trifluoromethyl group at 4-position of the pyridyl ring. 2-Pyridones are well-known organic compounds to form dimers via hydrogen bonding. 4-(Trifluoromethyl)-2-pyridone is a classic example that exists as tautomers, hence also known as 2-hydroxy-4-(trifluoromethyl)pyridine.

4-(Trifluoromethyl)-2-pyridinone, 2-Hydroxy-4-(trifluoromethyl)pyridine

The trifluoromethyl group is considered to be one of the most powerful electron withdrawing groups yet with a significant electronegativity between that of fluorine and chlorine. Pyridone is a well known inhibitor for serotonin uptake used to treat major depressive disorder.

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated building block

Fluorinated pyridone building block

For semiconductors, photocatalysts, and semiconductors

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High purity 50650-59-4

High purity

>98% High purity

General Information

CAS Number 50650-59-4
Chemical Formula C6H4F3NO
Full Name 4-(Trifluoromethyl)-2-pyridone
Molecular Weight 163.10 g/mol
Synonyms 2-Hydroxy-4-(trifluoromethyl)pyridine, 4-(Trifluoromethyl)pyridin-2-ol
Classification / Family Pyridone derivatives, Semiconductor synthesis intermediates, Organometallic compounds, Photocatalyst

Chemical Structure

4-(Trifluoromethyl)-2-pyridone chemical structure, 50650-59-4
4-(Trifluoromethyl)-2-pyridinone chemical structure, CAS 50650-59-4

Product Details

Purity >98% (1H NMR)
Melting Point Tm = 158 °C
Appearance White powder

MSDS Documentation

4-(Trifluoromethyl)-2-pyridone4-(Trifluoromethyl)-2-pyridone MSDS Sheet

Literature and Reviews

  1. Evaluation of chemical compounds for induction of male sterility in wheat (Triticum aestivum L.), K. Hakrabortyet al., Euphytica 147, 329–335 (2006); DOI: 10.1007/s10681-005-9025-z.
  2. Oxyfunctionalization of pyridine derivatives using whole cells of Burkholderia sp. MAK1, J. Stankevičiūtė et al., Sci. Rep. 6, 39129 (2016); DOI: 10.1038/srep39129.
  3. Synthesis of Novel Analogues of Marine Indole Alkaloids: Mono(indolyl)-4-trifluoromethylpyridines and Bis(indolyl)-4-trifluoromethylpyridines as Potential Anticancer Agents, W. Xiong et al., Bioorg. Med. Chem., 9 (7), 1773-1780 (2001); DOI: 10.1016/S0968-0896(01)00070-0.

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