FREE shipping to on qualifying orders when you spend or more, processed by Ossila BV. All prices ex. VAT. Qualifying orders ship free worldwide! Fast, secure, and backed by the Ossila guarantee. It looks like you are visiting from , click to shop in or change country. Orders to the EU are processed by our EU subsidiary.

It looks like you are using an unsupported browser. You can still place orders by emailing us on, but you may experience issues browsing our website. Please consider upgrading to a modern browser for better security and an improved browsing experience.

Methyl pentafluorobenzoate

CAS Number 36629-42-2

Chemistry Building Blocks, Fluorinated Building Blocks, Materials, Monomers

Product Code B2331-10g
Price £76 ex. VAT

A perfluorinated benzoate building block

A synthesis intermediate for graft polymers, covalently bonded nanocomposites and luminescence metal complexes

Specifications | MSDS | Literature and Reviews

Methyl pentafluorobenzoate (CAS number 36629-42-2) or methyl perfluorobenzoate is a fully fluorinated benzoic acid methyl ester. Methyl pentafluorobenzoate is used to synthesize linkers for graft polymers such as perfluorophenyl azide with N-hydroxysuccinimide end group (PFPA-NHS). To synthesize PFPA-NHS, it begins with a nucleophilic aromatic substitution of sodium azide to the para-position of ester. The hydrolysis of the ester is followed forming an azide perfluorobenzoic acid. The last step involves an EDC (1-ethyl-3-(3-dimethylaminopropyl)carbodiimide) catalysed coupling reaction of N-hydroxysuccinimide and the carboxylic acid. PFPA-NHS has been used for preparing polyaniline grafted graphene and catalase grafted polycaprolactone.

After the hydrolysis of the ester group, methyl pentafluorobenzoate binds to cadmium for luminescence metal complexes with overall quantum yield up to 39%.

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated building block

Fluorinated benzoate building block

For drug discovery, metal complexes and polymer chemistry

Worldwide shipping for 36629-42-2

Worldwide shipping

Quick and reliable shipping

High purity 36629-42-2

High purity

>97% High purity

General Information

CAS Number 36629-42-2
Chemical Formula C8H3F5O2
Full Name Methyl pentafluorobenzoate
Molecular Weight 226.10 g/mol
Synonyms Pentafluorobenzoic acid methyl ester, Perfluorobenzoic acid methyl ester, Methyl perfluorobenzoate
Classification / Family Fluorinated building blocks, Aromatic building blocks, Graft polymer, Luminescence metal complexes

Chemical Structure

Methyl pentafluorobenzoate chemical structure, CAS 36629-42-2
Methyl pentafluorobenzoate chemical structure, CAS 36629-42-2

Product Details

Purity 97%
Boiling Point Tb = 223 °C at 760 mmHg
Relative Density 1.53 g/mL at 25 °C
Appearance Colourless liquid

MSDS Documentation

Methyl pentafluorobenzoateMethyl pentafluorobenzoate MSDS Sheet

Literature and Reviews

  1. A simple route to functionalising electrospun polymer scaffolds with surface biomolecules, K. Dziemidowicz et al., Int. J. Pharm., 597, 120231(2021); DOI: 10.1016/j.ijpharm.2021.120231.
  2. Functionalization of pristine graphene for the synthesis of covalent graphene-polyaniline nanocomposite, J. Park et al., RSC Adv., 10, 26486(2020); DOI: 10.1039/d0ra03579c.
  3. Photocatalytic C–F alkylation: facile access to multifluorinated arenes, A. Singh et al., Chem. Sci., 6, 7206(2015); DOI: 10.1039/c5sc03013g.
Return to the top