FREE shipping to on qualifying orders when you spend or more, processed by Ossila BV. All prices ex. VAT. Qualifying orders ship free worldwide! Fast, secure, and backed by the Ossila guarantee. It looks like you are visiting from , click to shop in or change country. Orders to the EU are processed by our EU subsidiary.

It looks like you are using an unsupported browser. You can still place orders by emailing us on info@ossila.com, but you may experience issues browsing our website. Please consider upgrading to a modern browser for better security and an improved browsing experience.


Product Code B2561-1g
Price £90 ex. VAT

A gem-fluorinated cyclopropanecarboxylic acid building block

Used as a synthesis intermediate for APIs


Specifications | MSDS | Literature and Reviews


2,2-Difluorocyclopropanecarboxylic acid (CAS number 107873-03-0) is a 3-membered ring substituted with two fluorines and a carboxylic acid. The inductive effect introduced by the gem-difluorination enhances the acidity of 2,2-difluorocyclopropanecarboxylic acid, compared to the non-fluorinated species. The carboxylic acid allows 2,2-difluorocyclopropanecarboxylic acid to be attached to molecular scaffolds through esterification. It can also undergo functional group conversion to form acyl halide, isocyanate and amine, for varied reactivities.

An unexpected ring-opening has been discovered while 2,2-difluorocyclopropanecarboxylic acid reacts with arenes in Friedel-Crafts reaction. It is proposed that the formation of the acylium ion destabilises the strained 3-membered ring leading to the ring-opening reaction.

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated building block

Fluorinated cyclopropane building block

For organic synthesis, medicinal chemistry and biochemistry research

Worldwide shipping for 107873-03-0

Worldwide shipping

Quick and reliable shipping

High purity 107873-03-0

High purity

>97% High purity

General Information


CAS Number 107873-03-0
Chemical Formula C4H4F2O2
Full Name 2,2-Difluorocyclopropanecarboxylic acid
Molecular Weight 122.07 g/mol
Synonyms 2,2-Difluorocyclopropane-1-carboxylic Acid
Classification / Family Fluorinated building blocks, Carboxylic acid building blocks, APIs

Chemical Structure


2,2-Difluorocyclopropanecarboxylic acid chemical structure, CAS 107873-03-0.
2,2-Difluorocyclopropanecarboxylic acid chemical structure, CAS 107873-03-0

Product Details


Purity 97%
Melting Point Tm = 60 °C – 65 °C
Appearance Off-white powder

MSDS Documentation


2,2-Difluorocyclopropanecarboxylic acid MSDS Sheet2,2-Difluorocyclopropanecarboxylic acid MSDS Sheet

Literature and Reviews


  1. Dual inhibition of TYK2 and JAK1 for the treatment of autoimmune diseases: discovery of ((S)-2,2-difluorocyclopropyl)((1R,5S)-3-(2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841), A. Fensome et al., J. Med. Chem., 61(19), 8597–8612(2018); DOI: 10.1021/acs.jmedchem.8b00917.
  2. Effect of gem-difluorination on the key physicochemical properties relevant to medicinal chemistry: the case of functionalized cycloalkanes, S. Holovach et al., Chem. Eur. J., 28(19), e202200331(2022); DOI: 10.1002/chem.202200331.
  3. Friedel-Crafts reactions of 2,2-difluorocyclopropanecarbonyl chloride: unexpected ring-opening chemistry, W. Dolbier et al., J. Org. Chem., 76(9), 3450–3456(2011); DOI: 10.1021/jo200423y.
Return to the top