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Product Code B3361-5g
Price $44 ex. VAT

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A dihalogenated acetophenone building block

As a synthesis intermediate for APIs, chalcone derivatives and carbazole derivatives


3′-Bromo-4′-fluoroacetophenone (CAS number 1007-15-4) is an acetophenone derivative featuring meta-bromide and para-fluoride function groups. Para/meta-substituted acetophenones have shown antimicrobial activity with inhibitory concentration as low as 246 µM. 3′-Bromo-4′-fluoroacetophenone is applied as a precursor for the synthesis of chalcone, an α,β-unsaturated ketone that is utilised in drug discovery, liquid crystals and optical materials.

3′-Bromo-4′-fluoroacetophenone is also a precursor for an acetyl-functionalised carbazole through a tandem Suzuki-coupling/SNAr approach.

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated acetophenone building block

Fluorinated acetophenone building block

For drug discovery, chalcone derivatives, and carbazole derivatives

competitively priced 1007-15-4

Low Cost

Competitively priced, high quality product

High purity 1007-15-4

High purity

>98% High purity

General Information

CAS Number 1007-15-4
Chemical Formula C8H6BrFO
Full Name 1-(3-Bromo-4-fluorophenyl)ethanone
Molecular Weight 217.04 g/mol
Synonyms 1-(3-Bromo-4-fluorophenyl)ethan-1-one, 1-Acetyl-3-bromo-4-fluorobenzene
Classification / Family Fluorinated building blocks, Brominated building blocks, Acetophenone building blocks, APIs, Chalcone precursors, Carbazole precursors

Chemical Structure

3′-Bromo-4′-fluoroacetophenone chemical structure, CAS 1007-15-4
3′-Bromo-4′-fluoroacetophenone chemical structure, CAS 1007-15-4

Product Details

Purity 98%
Melting Point Tm = 52 °C – 57 °C
Appearance Yellow/light brown powder/crystals

MSDS Documentation

3′-Bromo-4′-fluoroacetophenone3′-Bromo-4′-fluoroacetophenone MSDS Sheet

Literature and Reviews

  1. Large enhancement of nonlinear optical absorption and refraction in planar chalcone structure with terminal substitution, J. Chen et al., Opt. Mater., 146, 114519 (2023); DOI: 10.1016/j.optmat.2023.114519.
  2. A tandem cross-Coupling/SNAr approach to functionalized carbazoles, D. St. Jean et al, Org. Lett., 9 (23), 4893–4896 (2007); DOI: 10.1021/ol702274y.
  3. Acetophenones with selective antimycobacterial activity, L. Rajabi et al., Lett. Appl. Microbiol., 40, 212–217 (2005); DOI: 10.1111/j.1472-765X.2005.01657.x.
  4. Dynamic imaging of LDH inhibition in tumors reveal rapid in vivo metabolic rewiring and vulnerability to combination therapy, N. Oshima et al., Cell Reports, 30, 1798–1810 (2020); DOI: 10.1016/j.celrep.2020.01.039.

To the best of our knowledge the information provided here is accurate. The values provided are typical at the time of manufacture and may vary over time and from batch to batch. Products may have minor cosmetic differences (e.g. to the branding) compared to the photos on our website. All products are for laboratory and research and development use only.

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