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2-Fluoro-4-nitroaniline

CAS Number 369-35-7

Chemistry Building Blocks, Fluorinated Building Blocks, Monomers


Product Code B2671-10g
Price $88 ex. VAT

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A fluorinated aniline building block

Used as a synthesis intermediate for APIs, colour centre-tailored carbon nanotubes and anode materials in Li-ion batteries


2-Fluoro-4-nitroaniline, (CAS number 369-35-7) is an aniline derivative bearing a fluoride and a nitro group at 2- and 4-positions. 2-Fluoro-4-nitroaniline serves as a versatile molecular scaffold for synthesising active pharmaceutical ingredients (APIs). The amine group conducts nucleophilic substitution and diazotization. The nitro group can be laterally reduced to amine for further reactions. A precursor to the antibiotic candidate TBI-233 is synthesised from 2-fluoro-4-nitroaniline.

2-Fluoro-4-nitroaniline was used to introduce sp3 defects onto semiconducting single-walled carbon nanotubes (SWCNTs) for organic colour centre-tailored carbon nanotubes. A lithium bismaleamate anode material is synthesised from 2-fluoro-4-nitroaniline, demonstrating an electrode capacity of 688.9 mAhg−1.

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated building block

Fluorinated aniline building block

For semiconductors, batteries and colour centre-tailored carbon nanotubes

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High purity 369-35-7

High purity

>97% High purity

General Information

CAS Number 369-35-7
Chemical Formula C6H5FN2O2
Full Name 2-Fluoro-4-nitroaniline
Molecular Weight 156.11 g/mol
Synonyms 2-Fluoro-4-nitrobenzenamine
Classification / Family Fluorinated building blocks, Aniline building blocks, APIs, Li-ion batteries, Anode materials, Colour centre-tailored carbon nanotubes

Chemical Structure

2-Fluoro-4-nitroaniline chemical structure, CAS 369-35-7.
2-Fluoro-4-nitroaniline chemical structure, CAS 369-35-7

Product Details

Purity 97%
Melting Point Tm = 122 °C – 130 °C
Appearance Brown powder

MSDS Documentation

2-Fluoro-4-nitroaniline2-Fluoro-4-nitroaniline MSDS Sheet

Literature and Reviews

  1. Synthesis, characteristics, and electrochemical performance of N,N-(p-phenylene)bismaleamate and its fluorosubstitution compound on organic anode materials in lithium-ion batteries, B. Kahsay et al., Electrochim. Acta, 365, 137342(2021); 10.1016/j.electacta.2020.137342.
  2. Practical and scalable two-step process for 6-(2-fluoro-4-nitrophenyl)-2-oxa-6-azaspiro[3.3]heptane: a key intermediate of the potent antibiotic drug candidate TBI-223, F. Cardoso et al., Org. Process Res. Dev., 27, 1390–1399(2023); DOI: 10.1021/acs.oprd.3c00148.
  3. Discovery of novel conjugates of quinoline and thiazolidinone urea as potential anti-colorectal cancer agent, L. Xiong et al., J. Enzyme Inhib. Med. Chem., 37(1), 2334–2347(2022); DOI: 10.1080/14756366.2022.2117318.
  4. One-pot, large-scale synthesis of organic color center-tailored semiconducting carbon nanotubes, H.-B. Luo et al., ACS Nano, 13, 8417–8424(2019); DOI: 10.1021/acsnano.9b04087.
  5. Lowering the pKa of a bisimidazoline lead with halogen atoms results in improved activity and selectivity against Trypanosoma brucei in vitro, C. Martínez et al., Eur. J. Med. Chem., 101, 806–817(2015); DOI: 10.1016/j.ejmech.2015.07.013.

To the best of our knowledge the information provided here is accurate. The values provided are typical at the time of manufacture and may vary over time and from batch to batch. Products may have minor cosmetic differences (e.g. to the branding) compared to the photos on our website. All products are for laboratory and research and development use only.

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