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Product Code B2671-10g
Price £70 ex. VAT

A fluorinated aniline building block

Used as a synthesis intermediate for APIs, colour centre-tailored carbon nanotubes and anode materials in Li-ion batteries

2-Fluoro-4-nitroaniline, (CAS number 369-35-7) is an aniline derivative bearing a fluoride and a nitro group at 2- and 4-positions. 2-Fluoro-4-nitroaniline serves as a versatile molecular scaffold for synthesising active pharmaceutical ingredients (APIs). The amine group conducts nucleophilic substitution and diazotization. The nitro group can be laterally reduced to amine for further reactions. A precursor to the antibiotic candidate TBI-233 is synthesised from 2-fluoro-4-nitroaniline.

2-Fluoro-4-nitroaniline was used to introduce sp3 defects onto semiconducting single-walled carbon nanotubes (SWCNTs) for organic colour centre-tailored carbon nanotubes. A lithium bismaleamate anode material is synthesised from 2-fluoro-4-nitroaniline, demonstrating an electrode capacity of 688.9 mAhg−1.

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated building block

Fluorinated aniline building block

For semiconductors, batteries and colour centre-tailored carbon nanotubes

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High purity 369-35-7

High purity

>97% High purity

General Information

CAS Number 369-35-7
Chemical Formula C6H5FN2O2
Full Name 2-Fluoro-4-nitroaniline
Molecular Weight 156.11 g/mol
Synonyms 2-Fluoro-4-nitrobenzenamine
Classification / Family Fluorinated building blocks, Aniline building blocks, APIs, Li-ion batteries, Anode materials, Colour centre-tailored carbon nanotubes

Chemical Structure

2-Fluoro-4-nitroaniline chemical structure, CAS 369-35-7.
2-Fluoro-4-nitroaniline chemical structure, CAS 369-35-7

Product Details

Purity 97%
Melting Point Tm = 122 °C – 130 °C
Appearance Brown powder

MSDS Documentation

2-Fluoro-4-nitroaniline2-Fluoro-4-nitroaniline MSDS Sheet

Literature and Reviews

  1. Synthesis, characteristics, and electrochemical performance of N,N-(p-phenylene)bismaleamate and its fluorosubstitution compound on organic anode materials in lithium-ion batteries, B. Kahsay et al., Electrochim. Acta, 365, 137342(2021); 10.1016/j.electacta.2020.137342.
  2. Practical and scalable two-step process for 6-(2-fluoro-4-nitrophenyl)-2-oxa-6-azaspiro[3.3]heptane: a key intermediate of the potent antibiotic drug candidate TBI-223, F. Cardoso et al., Org. Process Res. Dev., 27, 1390–1399(2023); DOI: 10.1021/acs.oprd.3c00148.
  3. Discovery of novel conjugates of quinoline and thiazolidinone urea as potential anti-colorectal cancer agent, L. Xiong et al., J. Enzyme Inhib. Med. Chem., 37(1), 2334–2347(2022); DOI: 10.1080/14756366.2022.2117318.
  4. One-pot, large-scale synthesis of organic color center-tailored semiconducting carbon nanotubes, H.-B. Luo et al., ACS Nano, 13, 8417–8424(2019); DOI: 10.1021/acsnano.9b04087.
  5. Lowering the pKa of a bisimidazoline lead with halogen atoms results in improved activity and selectivity against Trypanosoma brucei in vitro, C. Martínez et al., Eur. J. Med. Chem., 101, 806–817(2015); DOI: 10.1016/j.ejmech.2015.07.013.
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