4-Fluoro-2-methylphenol

CAS Number 452-72-2

Fluorinated phenol derivative

Used as a synthesis intermediate for APIs and functional polymers

Overview
Related Products

4-Fluoro-2-methylphenol (CAS number 452-72-2), also knowns as 4-fluoro-o-cresol, is a para-fluorinated o-cresol. 4-Fluoro-2-methylphenol commonly serves as a building block for active pharmaceutical ingredients (APIs). Compared to non-substituted phenol, 4-fluoro-2-methylphenol offers selective inhibition over receptor tyrosine kinase and improves hepatocyte stability in quinazolines.

A tetradentate aminophenol ligand can be prepared from 4-fluoro-2-methylphenol, ethanolamine and formaldehyde via thermal Mannich condensation. A ligand-to-metal charge transfer (LMCT) complex synthesised from the aminophenol ligand and vanadium, demonstrates a charge transfer state with a lifetime of 423 ps. The long-lived LMCT complex is ideal for driving photochemical reactions. Furthermore, 4-Fluoro-2-methylphenol can be grafted onto natural polymer such as fax and coconut fibres catalysed by laccase for the modification of hydrophobicity.

Multiple functional groups

For facile synthesis

Fluorinated phenol building block

For graft polymers, medicinal chemistry and biochemistry research

Worldwide shipping

Quick and reliable shipping

High purity

>98% High purity

General Information

CAS Number	452-72-2
Chemical Formula	C₇H₇FO
Full Name	4-Fluoro-2-methylphenol
Molecular Weight	126.13 g/mol
Synonyms	4-Fluoro-o-cresol
Classification / Family	Fluorinated building blocks, Phenol building blocks, APIs, Graft polymers, Photoresists

Chemical Structure

Product Details

Purity	98%
Melting Point	T_m = 37 °C – 38 °C
Appearance	Pale yellow crystals

MSDS Documentation

4-Fluoro-2-methylphenol MSDS Sheet

Literature and Reviews

The discovery of 2-substituted phenol quinazolines as potent RET kinase inhibitors with improved KDR selectivity, R. Newton et al., Eur. J. Med. Chem., 112, 20–32(2016); DOI: 10.1016/j.ejmech.2016.01.039.
Fundamental understanding of chemical processes in extreme ultraviolet resist materials, O. Kostko et al., J. Chem. Phys., 149, 154305(2018); DOI: 10.1063/1.5046521.
Long-lived LMCT in a d⁰ vanadium(V) complex by internal conversion to a state of 3d_xy character, S. Choing et al., J. Phys. Chem. C, 119, 17029–17038(2015); DOI: 10.1021/acs.jpcc.5b00513.
Laccase functionalization of flax and coconut fibers, E. Acero et al, Polymers, 6, 1676–1684(2014); DOI: 10.3390/polym6061676.

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