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4-Fluoro-2-methylphenol

CAS Number 452-72-2

Fluorinated Building Blocks, Monomers


Product Code B2701-10g
Price $75 ex. VAT

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Fluorinated phenol derivative

Used as a synthesis intermediate for APIs and functional polymers


4-Fluoro-2-methylphenol (CAS number 452-72-2), also knowns as 4-fluoro-o-cresol, is a para-fluorinated o-cresol. 4-Fluoro-2-methylphenol commonly serves as a building block for active pharmaceutical ingredients (APIs). Compared to non-substituted phenol, 4-fluoro-2-methylphenol offers selective inhibition over receptor tyrosine kinase and improves hepatocyte stability in quinazolines.

A tetradentate aminophenol ligand can be prepared from 4-fluoro-2-methylphenol, ethanolamine and formaldehyde via thermal Mannich condensation. A ligand-to-metal charge transfer (LMCT) complex synthesised from the aminophenol ligand and vanadium, demonstrates a charge transfer state with a lifetime of 423 ps. The long-lived LMCT complex is ideal for driving photochemical reactions. Furthermore, 4-Fluoro-2-methylphenol can be grafted onto natural polymer such as fax and coconut fibres catalysed by laccase for the modification of hydrophobicity.

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated building block

Fluorinated phenol building block

For graft polymers, medicinal chemistry and biochemistry research

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High purity 452-72-2

High purity

>98% High purity

General Information

CAS Number 452-72-2
Chemical Formula C7H7FO
Full Name 4-Fluoro-2-methylphenol
Molecular Weight 126.13 g/mol
Synonyms 4-Fluoro-o-cresol
Classification / Family Fluorinated building blocks, Phenol building blocks, APIs, Graft polymers, Photoresists

Chemical Structure

4-Fluoro-2-methylphenol chemical structure, CAS 452-72-2.
4-Fluoro-2-methylphenol chemical structure, CAS 452-72-2

Product Details

Purity 98%
Melting Point Tm = 37 °C – 38 °C
Appearance Pale yellow crystals

MSDS Documentation

4-Fluoro-2-methylphenol4-Fluoro-2-methylphenol MSDS Sheet

Literature and Reviews

  1. The discovery of 2-substituted phenol quinazolines as potent RET kinase inhibitors with improved KDR selectivity, R. Newton et al., Eur. J. Med. Chem., 112, 20–32(2016); DOI: 10.1016/j.ejmech.2016.01.039.
  2. Fundamental understanding of chemical processes in extreme ultraviolet resist materials, O. Kostko et al., J. Chem. Phys., 149, 154305(2018); DOI: 10.1063/1.5046521.
  3. Long-lived LMCT in a d0 vanadium(V) complex by internal conversion to a state of 3dxy character, S. Choing et al., J. Phys. Chem. C, 119, 17029–17038(2015); DOI: 10.1021/acs.jpcc.5b00513.
  4. Laccase functionalization of flax and coconut fibers, E. Acero et al, Polymers, 6, 1676–1684(2014); DOI: 10.3390/polym6061676.

To the best of our knowledge the information provided here is accurate. The values provided are typical at the time of manufacture and may vary over time and from batch to batch. Products may have minor cosmetic differences (e.g. to the branding) compared to the photos on our website. All products are for laboratory and research and development use only.

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