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Product Code B1781-25g
Price £100 ex. VAT

A fluorinated heterocyclic building block

Used as a synthesis intermediate for Schiff bases, carbon nanodots and carbamates in application of APIs, OLEDs and antimicrobials

Specifications | MSDS | Literature and Reviews

3-Fluoro-4-morpholinoaniline (CAS number 93246-53-8) has a fluorinated aniline linked to a morpholine, a heterocycle featuring both amine and ether groups. By having the accessible primary amine, 3-fluoro-4-morpholinoaniline reacts with aldehyde to form Schiff bases. The Schiff base shows a better biofilm inhibition with IC50 (half maximal inhibitory concentration) of 12.97 μM, compared with linezolid (IC50 of 15.93 μM). 3-Fluoro-4-morpholinoaniline can also be modified for sulfonamide and carbamate derivatives that exhibit antimicrobial activity (minimum inhibitory concentration of 6.25-25.0 μg/mL).

4-Morpholinoaniline decorated phenylenediamine carbon nanodots show an improved photoluminescence quantum yield from 28.3% to 41.8%. The fluorinated 4-morpholinoaniline (3-fluoro-4-morpholinoaniline) can be applied to tune the emission wavelength of the carbon nanodots.

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated building block

Fluorinated morpholinoaniline building block

For drug discovery, carbon nanodots, and OLEDs

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High purity 93246-53-8

High purity

>98% High purity

General Information

CAS Number 93246-53-8
Chemical Formula C10H13FN2O
Full Name 3-Fluoro-4-morpholinoaniline
Molecular Weight 196.22 g/mol
Synonyms 4-(2-Fluoro-4-aminophenyl)morpholine, 3-Fluoro-4-morpholin-4-yl-phenylamine, 3-Fluoro-4-(4-morpholinyl)-benzenamine
Classification / Family Fluorinated building block, Heterocyclic building block, Schiff base, Carbon nanodots, APIs, OLEDs, Antimicrobials

Chemical Structure

3-Fluoro-4-morpholinoaniline chemical structure, CAS 93246-53-8
3-Fluoro-4-morpholinoaniline chemical structure, CAS 93246-53-8

Product Details

Purity >98%
Melting Point Tm = 121 °C – 123 °C
Appearance Off-white to pale beige powder

MSDS Documentation

3-Fluoro-4-morpholinoaniline MSDS Sheet3-Fluoro-4-morpholinoaniline MSDS Sheet

Literature and Reviews

  1. Synthesis and spectral characterization of Schiff base complexes of Cu(II), Co(II), Zn(II) and VO(IV) containing 4-(4-aminophenyl)morpholine derivatives: antimicrobial evaluation and anticancer studies, K. Dhahagani et al., Spectrochim. Acta A Mol. Biomol. Spectrosc., 117(3), 87-94(2014); DOI: 10.1016/j.saa.2013.07.101.
  2. Biofilm inhibition of linezolid-like Schiff bases: synthesis, biological activity, molecular docking and in silico ADME prediction, J. Sangshetti et al., Bioorg. Med. Chem., 25, 874-880(2015); DOI: 10.1016/j.bmcl.2014.12.063
  3. Electrochemical oxidation of 4-morpholinoaniline in nonaqueous solvents, R. Esmaili et al, J. Electrochem. Soc., 159(8), H680-H684(2012); DOI: 10.1149/2.014208jes.
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