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Product Code B1721-10g
Price $100 ex. VAT

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A fluorinated indole

Used as a synthesis intermediate for bioactive compounds and polyindoles in application of APIs, fluorine-labelling compounds, OLEDs, semiconductors and DSSCs


6-Fluoroindole (CAS number 399-51-9) is a fluorinated (6-position) indole, a benzene ring fused pyrrole heterocycle. 6-Fluoroindole is an antimicrobial which works by interfering with the quorum sensing system of the pathogens. 6-Fluoroindole inhibits the biofilm formation that causes infections.

6-Fluoroindole can be easily functionalized with Bpin groups (pinacol boronate) at 2-, 3-, 4-, 5- and 7-positions selectively with iridium-catalysed borylation and bismuth-catalysed protodeboronation. The modification to 6-fluoroindole allows late-stage functionalization on different positions of the molecule, expanding the molecular library for drug discovery.

6-Fluoroindole is also used to label bacteria cells (Escherichia coli) in order to study the protein-protein interaction in vitro with 19F NMR and 15N-1H HSQC (heteronuclear single quantum coherence) NMR.

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated building block

Fluorinated indole building block

For drug discovery, OLEDs, and semiconductors

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High purity 399-51-9

High purity

>98% High purity

General Information

CAS Number 399-51-9
Chemical Formula C8H6FN
Full Name 6-Fluoro-1H-indole
Molecular Weight 135.14 g/mol
Synonyms N/A
Classification / Family Fluorinated building block, Heterocyclic building block, APIs, OLEDs, Semiconductors, DSSCs

Chemical Structure

6-Fluoroindole chemical structure, CAS 399-51-9
6-Fluoroindole chemical structure, CAS 399-51-9

Product Details

Purity 98%
Melting Point Tm = 72 °C – 76 °C
Appearance Off-white powder

MSDS Documentation

6-Fluoroindole6-Fluoroindole MSDS Sheet

Literature and Reviews

  1. Antibiofilm and antivirulence properties of indoles against Serratia marcescens, S. Sethupathy et al., Front. Microbiol., 11, 584812(2020); DOI: 10.3389/fmicb.2020.584812.
  2. Bismuth acetate as a catalyst of the sequential protodeboronation of di- and triborylated indoles, F. Shen et al., Org Lett., 18(7), 1554–1557(2016); DOI: 10.1021/acs.orglett.6b00356.
  3. Hexafluoroisopropyl carbamates as selective MAGL and dual MAGL/FAAH inhibitors: biochemical and physiochemical properties, M. Barth et al., ChemMedChem, 17, e202100757(2022); DOI: 10.1002/cmdc.202100757.
  4. Fluoro-recognition: new in vivo fluorescent assay for toluene dioxygenase probing induction by and metabolism of polyfluorinated compounds, K. Aukema et al., Environ Microbiol., 24, 5202–5216(2022); DOI: 10.1111/1462-2920.16187.
  5. The intracellular environment affects protein-protein interactions, S, Speer et al., PNAS, 18(11), e2019918118(2021); DOI: 10.1073/pnas.2019918118.

To the best of our knowledge the information provided here is accurate. The values provided are typical at the time of manufacture and may vary over time and from batch to batch. Products may have minor cosmetic differences (e.g. to the branding) compared to the photos on our website. All products are for laboratory and research and development use only.

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