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2-Fluoro-4-hydroxybenzoic acid

CAS Number 65145-13-3

Chemistry Building Blocks, Fluorinated Building Blocks, Monomers


Product Code B2751-10g
Price $113 ex. VAT

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A fluorinated benzoic acid building block

Used as an intermediate for synthesising liquid crystals and APIs


2-Fluoro-4-hydroxybenzoic acid (CAS number 65145-13-3), a para-hydroxybenzoic acid, carries a fluoride group at ortho-position. The para-positioning of carboxylic acid and hydroxy in 2-fluoro-4-hydroxybenzoic acid is preferred for synthesising mesogens used in liquid crystal. The long alkyl tail readily attaches to the molecule with alkyl bromide under basic condition. The ortho-positioned fluoride group introduces an additional intercalated smectic phase.

In cancer immunotherapy, an immunoadjuvant is synthesised with 2-fluoro-4-hydroxybenzoic acid and polyphosphorzene. The reaction initiates with a ring-opening polymerisation of hexachlorocyclotriphosphazene, followed by a nucleophilic substitution of the deprotonated phenoxide from 2-fluoro-4-hydroxybenzoic acid.

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated building block

Fluorinated hydroxybenzoic acid building block

For drug discovery, liquid crystals and biochemistry research

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High purity 65145-13-3

High purity

>98% High purity

General Information

CAS Number 65145-13-3
Chemical Formula C7H5FO3
Full Name 2-Fluoro-4-hydroxybenzoic acid
Molecular Weight 156.11 g/mol
Synonyms 4-Hydroxy-2-fluorobenzoic acid
Classification / Family Fluorinated building blocks, Benzoic acid building blocks, Liquid crystals, APIs

Chemical Structure

2-Fluoro-4-hydroxybenzoic acid chemical structure, CAS 65145-13-3.
2-Fluoro-4-hydroxybenzoic acid chemical structure, CAS 65145-13-3

Product Details

Purity 98%
Melting Point Tm = 200 °C – 202 °C
Appearance White powder

MSDS Documentation

2-Fluoro-4-hydroxybenzoic acid2-Fluoro-4-hydroxybenzoic acid MSDS Sheet

Literature and Reviews

  1. Synthesis and structure–activity relationship studies of derivatives of the dual aromatase–sulfatase inhibitor 4-{[(4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]methyl}phenyl sulfamate, L. Woo et al., ChemMedChem, 8, 779–799(2013); DOI: 10.1002/cmdc.201300015.
  2. New phase sequences in banana-shaped mesogens: influence of fluorine substituent in compounds derived from 2,7-dihydroxynaphthalene, A. Reddy et al., J. Mater. Chem., 14, 1936–1947(2004); DOI: 10.1039/B313295A.
  3. Spontaneous formation of chiral macrostructures in achiral hockey-stick liquid crystals, A. Belaissaoui et al., Liq. Cryst., 40(6), 822–830(2013); DOI: 10.1080/02678292.2013.780268.
  4. Fluorine-functionalized polyphosphazene immunoadjuvant: synthesis, solution behavior and in vivo potency, H. Tagad et al., Molecules, 28, 4218(2023); DOI: 10.3390/molecules28104218.

To the best of our knowledge the information provided here is accurate. The values provided are typical at the time of manufacture and may vary over time and from batch to batch. Products may have minor cosmetic differences (e.g. to the branding) compared to the photos on our website. All products are for laboratory and research and development use only.

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