6-Fluoro-4-hydroxy-2-(trifluoromethyl)quinoline

CAS Number 31009-34-4

Chemistry Building Blocks, Fluorinated Building Blocks, Heterocyclic Building Blocks, Monomers

6-Fluoro-4-hydroxy-2-(trifluoromethyl)quinoline MSDS

6-Fluoro-4-hydroxy-2-(trifluoromethyl)quinoline CAS 31009-34-4

A fluorinated hydroxyquinoline building block

Used as an intermediate for the synthesis of antitubercular and antiplasmodial agents

Overview
Related Products

6-Fluoro-4-hydroxy-2-(trifluoromethyl)quinoline (CAS number 31009-34-4) is a derivative of quinoline, substituted with trifluoromethyl, hydroxyl and fluoride groups. 6-Fluoro-4-hydroxy-2-(trifluoromethyl)quinoline can exist in a tautomeric form, known as quinolone, where the hydroxy group becomes a ketone and the imine changes to an amine. 6-Fluoro-4-hydroxy-2-(trifluoromethyl)quinoline serves as a precursor for synthesising thioquinolines, which are used to develop non-cytotoxic, potent and selective antitubercular agents. The thiolation reaction is carried out using phosphorus pentasulfide in pyridine.

6-Fluoro-4-hydroxy-2-(trifluoromethyl)quinoline tautomer — The tautomer of 6-fluoro-4-hydroxy-2-(trifluoromethyl)quinoline

Furthermore, the hydroxyl group in 6-fluoro-4-hydroxy-2-(trifluoromethyl)quinoline can undergo nucleophilic substitution to synthesis antiplasmodial agents for the treatment of malaria.

Multiple functional groups

For facile synthesis

Fluorinated quinoline building block

For drug discovery, medicinal chemistry and biochemistry research

Worldwide shipping

Quick and reliable shipping

High purity

>98% High purity

General Information

CAS Number	31009-34-4
Chemical Formula	C₁₀H₅F₄NO
Full Name	6-Fluoro-2-(trifluoromethyl)-4-quinolinol
Molecular Weight	231.15 g/mol
Synonyms	6-fluoro-2-(trifluoromethyl)quinolin-4-ol
Classification / Family	Fluorinated building blocks, Heterocyclic building blocks, Quinoline building blocks, APIs

Chemical Structure

Product Details

Purity	98%
Melting Point	T_m = 259 °C – 263 °C
Appearance	Off-white powder

MSDS Documentation

6-Fluoro-4-hydroxy-2-(trifluoromethyl)quinoline MSDS Sheet

Literature and Reviews

Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved drug resistance properties, G. Freeman et al., J. Med. Chem., 47(24), 5923–5936(2004); DOI: 10.1021/jm040072r.
Measurement of interfluorine distance in solids, M. Gilchrist et al., J. Magn. Reson., 152, 1–6(2001), DOI: 10.1006/jmre.2001.2351.
4-Substituted thioquinolines and thiazoloquinolines: potent, selective, and Tween-80 in vitro dependent families of antitubercular agents with moderate in vivo activity, ChemMedChem.,6(12), 2252–2263(2011); DOI: 10.1002/cmdc.201100309.
Nopol-based quinoline derivatives as antiplasmodial agents, R. Nyamwihura et al., Molecules, 26, 1008(2021); DOI: 10.3390/molecules26041008.

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