3,3-Difluoropyrrolidine hydrochloride

A fluorinated non-aromatic heterocyclic building block

An amino building block for APIs and ferroelectrics

Specifications | MSDS | Literature and Reviews

3,3-Difluoropyrrolidine hydrochloride (CAS number 163457-23-6) is a fluorinated pyrrolidine salt with its amine being protonated by hydrochloric acid. 3,3-Difluoropyrrolidine hydrochloride is commonly used as a building block in medicinal chemistry for introducing the fluorinated pyrrolidine via nucleophilic substitution. The fluoride substituents improve the potency of the active pharmaceutical ingredients and the permeability through the cell membranes.

While deprotonated, 3,3-difluoropyrrolidine hydrochloride can coordinate to metal centres for ferroelectric complexes. A hybrid organic-inorganic ferroelectric (3,3-difluoropyrrolidinium)₂ZnCl₄·H₂O is synthesized from 3,3-difluoropyrrolidine showing a spontaneous polarization of 0.4 μC/cm².

Multiple functional groups

For facile synthesis

Fluorinated pyrrolidine building block

For drug discovery, ferroelectrics and organic synthesis

Worldwide shipping

Quick and reliable shipping

High purity

>97% High purity

General Information

Chemical Structure

Product Details

MSDS Documentation

3,3-Difluoropyrrolidine hydrochloride MSDS Sheet

Literature and Reviews

1. An organic-inorganic hybrid pyrrolidinium ferroelectric based on solvent selective effect, S. Jiao et al., Inorg. Chem., 60(22), 17212–17218(2021); DOI: 10.1021/acs.inorgchem.1c02536.
   
2. Application of fluorine in medicinal chemistry, E. Gillis et al., J. Med. Chem., 58(21), 8315–8359(2015); DOI: 10.1021/acs.jmedchem.5b00258.
   
3. Lead-free hybrid organic–inorganic ferroelectric: (3,3-difluoropyrrolidinium)₂ZnCl₄·H₂O, Inorg. Chem., 62(10), 4181–4187(2023); DOI: 10.1021/acs.inorgchem.2c04289.