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Product Code B2281-2g
Price $138 ex. VAT

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A fluorinated non-aromatic heterocyclic building block

An amino building block for APIs and ferroelectrics


3,3-Difluoropyrrolidine hydrochloride (CAS number 163457-23-6) is a fluorinated pyrrolidine salt with its amine being protonated by hydrochloric acid. 3,3-Difluoropyrrolidine hydrochloride is commonly used as a building block in medicinal chemistry for introducing the fluorinated pyrrolidine via nucleophilic substitution. The fluoride substituents improve the potency of the active pharmaceutical ingredients and the permeability through the cell membranes. 

While deprotonated, 3,3-difluoropyrrolidine hydrochloride can coordinate to metal centres for ferroelectric complexes. A hybrid organic-inorganic ferroelectric (3,3-difluoropyrrolidinium)2ZnCl4·H2O is synthesized from 3,3-difluoropyrrolidine showing a spontaneous polarization of 0.4 μC/cm2.

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated building block

Fluorinated pyrrolidine building block

For drug discovery, ferroelectrics and organic synthesis

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High purity 163457-23-6

High purity

>97% High purity

General Information

CAS Number 163457-23-6
Chemical Formula C4H8F2ClN
Full Name 3,3-Difluoropyrrolidine hydrochloride
Molecular Weight 143.56 g/mol
Synonyms N/A
Classification / Family Fluorinated building block, Heterocyclic building block, APIs, Ferroelectrics

Chemical Structure

3,3-Difluoropyrrolidine hydrochloride chemical structure, CAS 163457-23-6
3,3-Difluoropyrrolidine hydrochloride chemical structure, CAS 163457-23-6

Product Details

Purity 97%
Melting Point Tm = 134 °C
Appearance White powder

MSDS Documentation

3,3-Difluoropyrrolidine hydrochloride3,3-Difluoropyrrolidine hydrochloride MSDS Sheet

Literature and Reviews

  1. An organic-inorganic hybrid pyrrolidinium ferroelectric based on solvent selective effect, S. Jiao et al., Inorg. Chem., 60(22), 17212–17218(2021); DOI: 10.1021/acs.inorgchem.1c02536.
  2. Application of fluorine in medicinal chemistry, E. Gillis et al., J. Med. Chem., 58(21), 8315–8359(2015); DOI: 10.1021/acs.jmedchem.5b00258.
  3. Lead-free hybrid organic–inorganic ferroelectric: (3,3-difluoropyrrolidinium)2ZnCl4·H2O, Inorg. Chem., 62(10), 4181–4187(2023); DOI: 10.1021/acs.inorgchem.2c04289.
  4. Novel triazolopyrimidine-derived cannabinoid receptor 2 agonists as potential treatment for inflammatory kidney diseases, M. Nettekoven et al., ChemMedChem, 11, 179–189(2016); DOI: 10.1002/cmdc.201500218.

To the best of our knowledge the information provided here is accurate. The values provided are typical at the time of manufacture and may vary over time and from batch to batch. Products may have minor cosmetic differences (e.g. to the branding) compared to the photos on our website. All products are for laboratory and research and development use only.

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