3,3-Difluoropyrrolidine hydrochloride

CAS Number 163457-23-6

Chemistry Building Blocks, Fluorinated Building Blocks, Heterocyclic Building Blocks, Monomers

3,3-Difluoropyrrolidine hydrochloride MSDS

3,3-Difluoropyrrolidine hydrochloride CAS 163457-23-6

A fluorinated non-aromatic heterocyclic building block

An amino building block for APIs and ferroelectrics

Overview
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3,3-Difluoropyrrolidine hydrochloride (CAS number 163457-23-6) is a fluorinated pyrrolidine salt with its amine being protonated by hydrochloric acid. 3,3-Difluoropyrrolidine hydrochloride is commonly used as a building block in medicinal chemistry for introducing the fluorinated pyrrolidine via nucleophilic substitution. The fluoride substituents improve the potency of the active pharmaceutical ingredients and the permeability through the cell membranes.

While deprotonated, 3,3-difluoropyrrolidine hydrochloride can coordinate to metal centres for ferroelectric complexes. A hybrid organic-inorganic ferroelectric (3,3-difluoropyrrolidinium)₂ZnCl₄·H₂O is synthesized from 3,3-difluoropyrrolidine showing a spontaneous polarization of 0.4 μC/cm².

Multiple functional groups

For facile synthesis

Fluorinated pyrrolidine building block

For drug discovery, ferroelectrics and organic synthesis

Worldwide shipping

Quick and reliable shipping

High purity

>97% High purity

General Information

CAS Number	163457-23-6
Chemical Formula	C₄H₈F₂ClN
Full Name	3,3-Difluoropyrrolidine hydrochloride
Molecular Weight	143.56 g/mol
Synonyms	N/A
Classification / Family	Fluorinated building block, Heterocyclic building block, APIs, Ferroelectrics

Chemical Structure

Product Details

Purity	97%
Melting Point	T_m = 134 °C
Appearance	White powder

MSDS Documentation

3,3-Difluoropyrrolidine hydrochloride MSDS Sheet

Literature and Reviews

An organic-inorganic hybrid pyrrolidinium ferroelectric based on solvent selective effect, S. Jiao et al., Inorg. Chem., 60(22), 17212–17218(2021); DOI: 10.1021/acs.inorgchem.1c02536.
Application of fluorine in medicinal chemistry, E. Gillis et al., J. Med. Chem., 58(21), 8315–8359(2015); DOI: 10.1021/acs.jmedchem.5b00258.
Lead-free hybrid organic–inorganic ferroelectric: (3,3-difluoropyrrolidinium)₂ZnCl₄·H₂O, Inorg. Chem., 62(10), 4181–4187(2023); DOI: 10.1021/acs.inorgchem.2c04289.
Novel triazolopyrimidine-derived cannabinoid receptor 2 agonists as potential treatment for inflammatory kidney diseases, M. Nettekoven et al., ChemMedChem, 11, 179–189(2016); DOI: 10.1002/cmdc.201500218.

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