6-Chloro-8-fluoroquinoline

CAS Number 52200-53-0

Chemistry Building Blocks, Fluorinated Building Blocks, Heterocyclic Building Blocks, Monomers

6-Chloro-8-fluoroquinoline CAS 52200-53-0

A fluorinated heterocyclic building block

Used as a synthesis intermediate for APIs, DSSCs and sensors

Overview
Related Products

6-Chloro-8-fluoroquinoline (CAS number 52200-53-0) is a fluorinated quinoline derivative with a chlorine and a fluorine at 6- and 8-position respectively. This building block is best known for its used in active pharmaceutical ingredients (APIs), such as Besifloxacin and Clinafloxacin in topical antibiotic treatments and conjunctive bacterial infections. Other than pharmaceutical uses, 6-Chloro-8-fluoroquinoline is a synthesis intermediate for Schiff bases, through nucleophilic aromatic substitution. These Schiff bases are used for metal-ion recognition sensors because their fluorescent emissions shift after chelating to a metal centre.

Besifloxacin chemical structure — Besifloxacin, a fluoroquinolone antibiotic

The Schiff bases formed by this building block are typically bidentate/tridentate ligands which readily coordinate to Ru and Ir ion centres to form dye complexes in applications of dye-sensitized solar cells(DSSCs).

Multiple functional groups

For facile synthesis

Worldwide shipping

Quick and reliable shipping

Fluorinated quinoline building block

For drug discoveries, dyes, and solar cells

High purity

>98% High purity

General Information

CAS Number	52200-53-0
Chemical Formula	C₉H₅ClFN
Full Name	6-Chloro-8-fluoroquinoline
Molecular Weight	181.59 g/mol
Synonyms	N/A
Classification / Family	Fluorinated building block, Heterocyclic building block, Quinoline derivatives, Schiff base, Dyes, Semiconductor synthesis intermediates, organic photovoltaics

Chemical Structure

Product Details

Purity	>98%
Melting Point	T_m = 79 °C – 81 °C
Appearance	White to yellow crystal

MSDS Documentation

6-Chloro-8-fluoroquinoline MSDS Sheet

Literature and Reviews

Besifloxacin ophthalmic suspension 0.6% in the treatment of bacterial conjunctivitis patients with Pseudomonas aeruginosa infections, B. Silverstein et al., Clin. Ophthalmol., 6, 1987-1996(2012); DOI: 10.2147/OPTH.S35715.
Clinafloxacin for the treatment of bacterial endocarditis, D. Levine et al., Clin. Infect. Dis., 38(5), 620-631(2004); DOI: 10.1086/381670.
Copper(II) complexes based on quinoline-derived Schiff-base ligands: synthesis, characterization, HSA/DNA binding ability, and anticancer activity, Med. Chem. Commun., 9, 1663–1672(2018); DOI: 10.1039/c8md00223a.
A fluorescent sensor based on binaphthol-quinoline Schiff base for relay recognition of Zn²⁺ and oxalate in aqueous media, L. Tang et al., J. Chem. Sci., 128(8), 1337-1343(2016); DOI: 10.1007/s12039-016-1124-y.
Enhanced in vivo wound healing efficacy of a novel hydrogel loaded with copper(II) Schiff base quinoline complex(CuSQ) solid lipid nanoparticles, D. Abou El-ezz et al., Pharmaceuticals, 15(8), 978(2022); DOI: 10.3390/ph15080978.
Nano-synthesis, characterization and spectroscopic studies of chromium (III) complex derived from new quinoline-2-one for solar cell fabrication, A. Salman., J. Phys.: Conf. Ser., 1853, 012021(2021); DOI: 10.1088/1742-6596/1853/1/012021/
Ruthenium-triphenylphosphine complex with pendent quinolyl Schiff base ligand: synthesis, spectral characterization and catalytic property, S. Kundu et al., J. Indian Chem. Soc., 92, 1847-1853(2015); DOI: 10.5281/zenodo.5599621.
Theoretical and experimental investigations of large stokes shift fluorophores based on a quinoline scaffold, B. Czaplińska et al., Molecules, 25, 2488(2020); DOI: 10.3390/molecules25112488.

Related Products

We stock a wide range of monomers available to purchase online. Please contact us if you cannot find what you are looking for.

Potassium nonafluoro-1-butanesulfonate

From £50

2-Fluorobiphenyl

From £40

Pentafluorobenzoic acid

From £30

2,4,5-Trifluorophenylacetic acid

From £40

4-Fluoro-1,2-phenylenediamine

From £35

5-Fluorobenzoxazole-2-thiol

From £45

5-Bromo-3-fluoropyridine-2-carboxylic acid

From £55

7-Fluoro-4-hydroxycoumarin

From £50

2-Amino-5-chloro-3-fluoropyridine

From £40

5-Fluoro-2-methylbenzoic acid

From £45

5-Bromo-4-fluoro-2-methylaniline

From £60

3′-Bromo-4′-fluoroacetophenone

From £35

3-Fluoro-5-(trifluoromethyl)benzoic acid

From £30

5-Chloro-2-fluorobenzonitrile

From £40

2-Fluoro-6-methylbenzoic acid

From £33

4′-Fluoro-3′-nitroacetophenone

From £35

4-Fluoro-3-methylbenzoic acid

From £50

1,3,5-Tris(3-fluoro-4-formylphenyl)benzene

£80
From £80

5-Chloro-2-fluorobenzoic acid

From £50

2-Fluoro-5-methylbenzoic acid

From £50

trans-3,4-Difluorocinnamic acid

From £50

4-Fluoro-2-iodobenzoic acid

From £35

3-Fluoro-4-iodopyridine

From £50

2-Chloro-5-fluoronitrobenzene

From £45

4-Bromo-3-fluorobenzonitrile

From £50

3-Bromo-5-fluorophenol

From £33

4-Bromo-3-fluoroiodobenzene

From £35

5-Difluoromethoxy-2-mercaptobenzimidazole

From £65

6-Fluoro-4-hydroxy-2-(trifluoromethyl)quinoline

From £95

4-Bromo-6-fluoroquinoline

From £95

4-Amino-2-(trifluoromethyl)pyridine

From £50

1-(3-Fluorophenyl)-1H-pyrazole-4-carbaldehyde

From £70

Methyl 6-fluoropyridine-2-carboxylate

From £85

4-Hydroxy-2-(trifluoromethyl)benzoic acid

From £65

5-Bromo-2-fluoropyrimidine

From £60

3-Chloro-5-fluoroaniline

From £65

6-Fluoropyridine-2-carbonitrile

From £80

4-Fluoro-4′-methoxybenzophenone

From £90

2,4,6-Trifluorophenylacetic acid

From £90

2,3,5,6-Tetrafluoro-4-hydroxybenzoic acid

From £80

2-Fluoropyridine-3-carbonitrile

From £90

2-Bromo-5-fluorobenzonitrile

From £60

1-Bromo-2-chloro-4-fluorobenzene

From £70

2-Fluoro-4-(trifluoromethyl)benzoic acid

From £100

3-Fluoro-4-methoxybenzoic acid

From £90

4-Methoxy-3-(trifluoromethyl)aniline

From £90

4-Fluoro-2-methylbenzonitrile

From £90

3-Fluoro-4-(trifluoromethyl)benzoic acid

From £90

3,5-Difluoropyridine-2-carbonitrile

From £90

5-Cyano-2-fluoropyridine

From £90

2,6-Difluorocinnamic aldehyde

From £90

2-Fluoro-4-hydroxybenzoic acid

From £90

3-Chloro-2-fluorobenzoic acid

From £75

2-Fluoro-3-methoxybenzaldehyde

From £137

3-Fluorobenzoic hydrazide

From £100

2-Amino-5-fluorobenzonitrile

From £80

4-Fluoro-2-methylphenol

From £60

2,4,5-Trifluorobenzonitrile

From £80

4-Chloro-3-fluoroaniline

From £50

2-Fluoro-4-nitroaniline

From £70

3-Fluoro-2-methylbenzoic acid

From £90

2-Amino-6-fluorobenzonitrile

From £90

3-Fluoro-p-anisidine

From £90

3′-Fluoro-4′-methoxyacetophenone

Price £90

2-Bromo-4-fluorobenzonitrile

From £80

3-Fluoro-2-pyridinecarbonitrile

From £70

2-Amino-3-fluoropyridine

From £80

3-Fluoro-4-hydroxybenzaldehyde

From £80

α,α-Difluorophenylacetic acid

From £70

3,3-Difluoropiperidine hydrochloride

From £60

2,2-Difluorocyclopropanecarboxylic acid

From £90

4-Fluoro-β-nitrostyrene

From £90

2,6-Dichloro-5-fluoro-3-pyridinecarbonitrile

From £90

2-Fluoro-4-(trifluoromethyl)aniline

From £90

N-Boc-4,4-difluoro-L-proline

From £70

3,4,5-Trifluorobenzoic acid

From £90

2-Bromo-3′-fluoroacetophenone

From £116

4-Fluororesorcinol

From £70

3,4,5-Trifluoroaniline

From £55

4-Fluorobenzenesulfonamide

From £65

2-Fluoro-5-nitrobenzoic acid

From £65

1-Bis(4-fluorophenyl)methyl piperazine

From £80

3,5-Difluorobenzonitrile

From £65

6-Fluoronicotinic acid

From £76

2-Bromo-4-fluoropyridine

From £125

3-Fluoro-2-hydroxybenzaldehyde

From £110

2-Chloro-5-fluoropyrimidine

From £100

2-Bromo-6-fluorobenzaldehyde

From £100

2-Fluoro-5-nitrobenzonitrile

From £72

Bis(4-fluorophenyl)methanol

From £105

N-Boc-trans-4-fluoro-L-proline

From £76

(S)-(+)-3-Fluoropyrrolidine hydrochloride

From £80

Methyl pentafluorobenzoate

From £76

5-Fluorosalicylic acid

From £110

(R)-(−)-3-Fluoropyrrolidine hydrochloride

From £72

4-Bromo-2,6-difluoroaniline

From £76

2-Fluoroadenine

From £90

3,3-Difluoropyrrolidine hydrochloride

From £110

4-Fluoro-3-nitrobenzoic acid

From £66

2-Amino-4-fluorophenol

From £56

2,4-Difluorobenzonitrile

From £66

2,4-Difluoro-(1H-1,2,4-triazolyl)acetophenone

From £100

4,4′-Bis(trifluoromethyl)-2,2′-bipyridine

From £100

5-Bromo-2-fluoropyridine

From £105

1-(tert-Butoxycarbonyl)-3-fluoro-4-piperidone

From £90

6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride

From £80

7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid

From £115

3-Fluoro-4-morpholinoaniline

From £100

Benzyl (3-Fluoro-4-morpholinophenyl)carbamate

From £100

5-Fluoroisatin

From £76

5-Fluorooxindole

From £200

5-(Trifluoromethoxy)isatin

From £115

6-Fluoroindole-2-carboxylic acid

From £105

6-Fluoroindole

From £80

5-Fluoroindole

From £100

7-Fluoroindole

From £170

3-(4-Fluorophenyl)-1-isopropylindole

From £100

4-Fluoroindole

From £100

4-(Trifluoromethyl)-1H-imidazole

From £165

1-[2-(Trifluoromethyl)phenyl]imidazole

From £175

3-(Trifluoromethyl)-2-pyridone

From £100

5-(Trifluoromethyl)-2-pyridone

From £100

2-(Trifluoromethyl)thioxanthen-9-one

Price £95

2-Furoyltrifluoroacetone

From £100

7-(Diethylamino)-4-(trifluoromethyl)coumarin

From £110

7-Hydroxy-4-(trifluoromethyl)coumarin

From £56

2-Fluoro-9H-carbazole

From £135

AB-TFMB

£90
From £90

p-6FDAP

£110
From £110

2,2-Bis(3-(3-aminobenzoylamino)-4-hydroxyphenyl)hexafluoropropane (m-6FDAP)

£130
From £130

2,2'-Bis(trifluoromethyl)-4,4'-diaminodiphenyl ether (6FODA)

£76
From £76

2,2-Bis[4-(4-aminophenoxy)phenyl]hexafluoropropane (4-BDAF)

£76
From £76

1,4-Bis(4-amino-2-trifluoromethylphenoxy)benzene (6FAPB)

£76
From £76

4,4'-(Hexafluoroisopropylidene)diphthalic anhydride (6FDA)

£90
From £90

2,2'-Bis(trifluoromethyl)benzidine (TFMB)

£76
From £76

2,2-Bis(3-amino-4-hydroxyphenyl)hexafluoropropane (6FAP)

£76
From £76

2-(2,4-Difluorophenyl)-5-fluoropyridine

From £105

2-(2,4-Difluorophenyl)-5-methylpyridine

From £130

4-Chloro-7-trifluoromethylquinoline-3-carboxylic acid ethyl ester

From £145

4-Bromo-8-fluoroquinoline

From £135

8-Fluoro-4-hydroxy-2-methylquinoline

From £95

(5S)-(−)-5-(Trifluoromethyl)-2-pyrrolidinone

From £145

2,4,6-Trifluoronitrobenzene

From £74

Ethyl (4-fluorobenzoyl)acetate

From £110

5-Bromo-3-fluorosalicylaldehyde

From £110

6-Fluoro-4-chromanone

From £120

2-(Difluoromethyl)benzimidazole

From £115

3,3-Difluoroazetidine hydrochloride

Price £170

4-(Trifluoromethyl)-2-pyridone

From £72

4-Fluoro-1H-indazole

From £72

3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

From £115

5,5'-Bis(trifluoromethyl)-2,2'-bipyridine

From £210

5,5'-dibromo-3,3'-difluoro-2,2'-bithiophene

From £250

2-Bromo-6-fluoronaphthalene

From £130

FIC

From £220

HDOQx-DBrDF

From £520

MeHDOQx-DBrDF

From £520

2FIC

From £360

BDTT-F-Sn

From £500

DFBTA-2ThBr-HD

From £310

3,3'-Difluoro-5,5'-bis(trimethylstannyl)-2,2'-bithiophene

From £280

2-Ethylhexyl 4,6-dibromo-3-fluorothieno[3,4-b]thiophene-2-carboxylate

From £260

4,7-Dibromo-5,6-difluoro-2,1,3-benzothiadiazole

From £210

PCE11 Monomer

From £480