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Product Code B1881-LT-1g
Price £80 ex. VAT

A fluorinated heterocyclic building block

Used as a synthesis intermediate for APIs, DSSCs and sensors

6-Chloro-8-fluoroquinoline (CAS number 52200-53-0) is a fluorinated quinoline derivative with a chlorine and a fluorine at 6- and 8-position respectively. This building block is best known for its used in active pharmaceutical ingredients (APIs), such as Besifloxacin and Clinafloxacin in topical antibiotic treatments and conjunctive bacterial infections. Other than pharmaceutical uses, 6-Chloro-8-fluoroquinoline is a synthesis intermediate for Schiff bases, through nucleophilic aromatic substitution. These Schiff bases are used for metal-ion recognition sensors because their fluorescent emissions shift after chelating to a metal centre.

Besifloxacin chemical structure
Besifloxacin, a fluoroquinolone antibiotic

The Schiff bases formed by this building block are typically bidentate/tridentate ligands which readily coordinate to Ru and Ir ion centres to form dye complexes in applications of dye-sensitized solar cells(DSSCs).

Multiple functional groups

Multiple functional groups

For facile synthesis

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Fluorinated building block

Fluorinated quinoline building block

For drug discoveries, dyes, and solar cells

High purity 52200-53-0

High purity

>98% High purity

General Information

CAS Number 52200-53-0
Chemical Formula C9H5ClFN
Full Name 6-Chloro-8-fluoroquinoline
Molecular Weight 181.59 g/mol
Synonyms N/A
Classification / Family Fluorinated building block, Heterocyclic building block, Quinoline derivatives, Schiff base, Dyes, Semiconductor synthesis intermediates, organic photovoltaics

Chemical Structure

6-Chloro-8-fluoroquinoline chemical structure, CAS 52200-53-0
6-Chloro-8-fluoroquinoline chemical structure, CAS 52200-53-0

Product Details

Purity >98%
Melting Point Tm = 79 °C – 81 °C
Appearance White to yellow crystal

MSDS Documentation

6-Chloro-8-fluoroquinoline6-Chloro-8-fluoroquinoline MSDS Sheet

Literature and Reviews

  1. Besifloxacin ophthalmic suspension 0.6% in the treatment of bacterial conjunctivitis patients with Pseudomonas aeruginosa infections, B. Silverstein et al., Clin. Ophthalmol., 6, 1987-1996(2012); DOI: 10.2147/OPTH.S35715.
  2. Clinafloxacin for the treatment of bacterial endocarditis, D. Levine et al., Clin. Infect. Dis., 38(5), 620-631(2004); DOI: 10.1086/381670.
  3. Copper(II) complexes based on quinoline-derived Schiff-base ligands: synthesis, characterization, HSA/DNA binding ability, and anticancer activity, Med. Chem. Commun., 9, 1663–1672(2018); DOI: 10.1039/c8md00223a.
  4. A fluorescent sensor based on binaphthol-quinoline Schiff base for relay recognition of Zn2+ and oxalate in aqueous media, L. Tang et al., J. Chem. Sci., 128(8), 1337-1343(2016); DOI: 10.1007/s12039-016-1124-y.
  5. Enhanced in vivo wound healing efficacy of a novel hydrogel loaded with copper(II) Schiff base quinoline complex(CuSQ) solid lipid nanoparticles, D. Abou El-ezz et al., Pharmaceuticals, 15(8), 978(2022); DOI: 10.3390/ph15080978.
  6. Nano-synthesis, characterization and spectroscopic studies of chromium (III) complex derived from new quinoline-2-one for solar cell fabrication, A. Salman., J. Phys.: Conf. Ser., 1853, 012021(2021); DOI: 10.1088/1742-6596/1853/1/012021/
  7. Ruthenium-triphenylphosphine complex with pendent quinolyl Schiff base ligand: synthesis, spectral characterization and catalytic property, S. Kundu et al., J. Indian Chem. Soc., 92, 1847-1853(2015); DOI: 10.5281/zenodo.5599621.
  8. Theoretical and experimental investigations of large stokes shift fluorophores based on a quinoline scaffold, B. Czaplińska et al., Molecules, 25, 2488(2020); DOI: 10.3390/molecules25112488.
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