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Product Code B2531-5g
Price $113 ex. VAT

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A fluorinated aniline building block

Used as a synthesis intermediate for heterocycle derivatives, triarylmethanes and phenylacetamides in application of APIs and dyes


2-Fluoro-4-(trifluoromethyl)aniline (CAS number 69409-98-9) is an aniline derivate, bearing a fluorine and a trifluoromethyl at 2- and 4-positions. The ortho-substituted fluorine can perform nucleophilic aromatic substitution, making 2-fluoro-4-(trifluoromethyl)aniline an excellent precursor for bicyclic heterocycles, such as quinoxalines and quinoline, as well as tricyclic heterocycles such as benzoimidazotriazines, phenazines and phenoxazines. 2-Fluoro-4-(trifluoromethyl)aniline can be used as a building block for ocfentanil derivatives as an analgesic.

2-Fluoro-4-(trifluoromethyl)aniline is also used to synthesise triarylmethane derivatives with para-quinone methides via conjugated addition.

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated building block

Fluorinated aniline building block

For drug discovery, medicinal chemistry and biochemistry research

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High purity 69409-98-9

High purity

>98% High purity

General Information

CAS Number 69409-98-9
Chemical Formula C7H5F4N
Full Name 2-Fluoro-4-(trifluoromethyl)aniline
Molecular Weight 179.11 g/mol
Synonyms 4-Amino-3-fluorobenzotrifluoride, 2-Fluoro-4-(trifluoromethyl)benzenamine
Classification / Family Fluorinated building block, Heterocycles, Triarylmethanes, APIs

Chemical Structure

2-Fluoro-4-(trifluoromethyl)aniline chemical structure, CAS 69409-98-9.
2-Fluoro-4-(trifluoromethyl)aniline chemical structure, CAS 69409-98-9

Product Details

Purity 98%
Boiling Point Tb = 55 °C at 0.3 mmHg
Appearance Colourless liquid

MSDS Documentation

2-Fluoro-4-(trifluoromethyl)aniline2-Fluoro-4-(trifluoromethyl)aniline MSDS Sheet

Literature and Reviews

  1. Synthesis and in vitro evaluation of 8-pyridinyl=substituted benzo[e]imidazo[2,1-c][1,2,4]triazines as phosphodiesterase 2A inhibitors, R. Ritawidya et al., Molecules, 24, 2791(2019); DOI: 10.3390/molecules24152791.
  2. Silver-catalyzed regioselective 1,6-hydroarylation of para-quinone methides with anilines and phenols, B, Xiong et al., Org. Chem. Front., 9, 3807–3817(2022); DOI: 10.1039/D2QO00541G.
  3. Synthesis and biological evaluation of 2-(3-fluoro-4-nitrophenoxy)-N-phenylacetamide derivatives as novel potenial affordable antitubercular agents, W. Ang et al., Molecules, 17, 2248–2258; DOI: 10.3390/molecules17022248.
  4. Fentanyls continue to replace heroin in the drug arena: the cases of ocfentanil and carfentanil, N. Misailidi et al., Forensic Toxicol., 36, 12–32(2018); DOI: 10.1007/s11419-017-0379-4.
  5. One-pot synthesis of 3-fluoro-4-(trifluoromethyl)quinolines from pentafluoropropen-2-ol and their molecular modification, T. Hosokawa et al., J. Org. Chem., 73(4), 1468–1474(2008); DOI: 10.1021/jo702568z.

To the best of our knowledge the information provided here is accurate. The values provided are typical at the time of manufacture and may vary over time and from batch to batch. Products may have minor cosmetic differences (e.g. to the branding) compared to the photos on our website. All products are for laboratory and research and development use only.

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