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Product Code B2531-5g
Price £90 ex. VAT

A fluorinated aniline building block

Used as a synthesis intermediate for heterocycle derivatives, triarylmethanes and phenylacetamides in application of APIs and dyes


Specifications | MSDS | Literature and Reviews


2-Fluoro-4-(trifluoromethyl)aniline (CAS number 69409-98-9) is an aniline derivate, bearing a fluorine and a trifluoromethyl at 2- and 4-positions. The ortho-substituted fluorine can perform nucleophilic aromatic substitution, making 2-fluoro-4-(trifluoromethyl)aniline an excellent precursor for bicyclic heterocycles, such as quinoxalines and quinoline, as well as tricyclic heterocycles such as benzoimidazotriazines, phenazines and phenoxazines. 2-Fluoro-4-(trifluoromethyl)aniline can be used as a building block for ocfentanil derivatives as an analgesic.

2-Fluoro-4-(trifluoromethyl)aniline is also used to synthesise triarylmethane derivatives with para-quinone methides via conjugated addition.

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated building block

Fluorinated aniline building block

For drug discovery, medicinal chemistry and biochemistry research

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High purity 69409-98-9

High purity

>98% High purity

General Information


CAS Number 69409-98-9
Chemical Formula C7H5F4N
Full Name 2-Fluoro-4-(trifluoromethyl)aniline
Molecular Weight 179.11 g/mol
Synonyms 4-Amino-3-fluorobenzotrifluoride, 2-Fluoro-4-(trifluoromethyl)benzenamine
Classification / Family Fluorinated building block, Heterocycles, Triarylmethanes, APIs

Chemical Structure


2-Fluoro-4-(trifluoromethyl)aniline chemical structure, CAS 69409-98-9.
2-Fluoro-4-(trifluoromethyl)aniline chemical structure, CAS 69409-98-9

Product Details


Purity 98%
Boiling Point Tb = 55 °C at 0.3 mmHg
Appearance Colourless liquid

MSDS Documentation


2-Fluoro-4-(trifluoromethyl)aniline2-Fluoro-4-(trifluoromethyl)aniline MSDS Sheet

Literature and Reviews


  1. Synthesis and in vitro evaluation of 8-pyridinyl=substituted benzo[e]imidazo[2,1-c][1,2,4]triazines as phosphodiesterase 2A inhibitors, R. Ritawidya et al., Molecules, 24, 2791(2019); DOI: 10.3390/molecules24152791.
  2. Silver-catalyzed regioselective 1,6-hydroarylation of para-quinone methides with anilines and phenols, B, Xiong et al., Org. Chem. Front., 9, 3807–3817(2022); DOI: 10.1039/D2QO00541G.
  3. Synthesis and biological evaluation of 2-(3-fluoro-4-nitrophenoxy)-N-phenylacetamide derivatives as novel potenial affordable antitubercular agents, W. Ang et al., Molecules, 17, 2248–2258; DOI: 10.3390/molecules17022248.
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