2-Fluoro-4-(trifluoromethyl)aniline

CAS Number 69409-98-9

Chemistry Building Blocks, Fluorinated Building Blocks, Monomers, Non-Heterocyclic Building Blocks

2-Fluoro-4-(trifluoromethyl)aniline MSDS

2-Fluoro-4-(trifluoromethyl)aniline CAS 69409-98-9

A fluorinated aniline building block

Used as a synthesis intermediate for heterocycle derivatives, triarylmethanes and phenylacetamides in application of APIs and dyes

Overview
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2-Fluoro-4-(trifluoromethyl)aniline (CAS number 69409-98-9) is an aniline derivate, bearing a fluorine and a trifluoromethyl at 2- and 4-positions. The ortho-substituted fluorine can perform nucleophilic aromatic substitution, making 2-fluoro-4-(trifluoromethyl)aniline an excellent precursor for bicyclic heterocycles, such as quinoxalines and quinoline, as well as tricyclic heterocycles such as benzoimidazotriazines, phenazines and phenoxazines. 2-Fluoro-4-(trifluoromethyl)aniline can be used as a building block for ocfentanil derivatives as an analgesic.

2-Fluoro-4-(trifluoromethyl)aniline is also used to synthesise triarylmethane derivatives with para-quinone methides via conjugated addition.

Multiple functional groups

For facile synthesis

Fluorinated aniline building block

For drug discovery, medicinal chemistry and biochemistry research

Worldwide shipping

Quick and reliable shipping

High purity

>98% High purity

General Information

CAS Number	69409-98-9
Chemical Formula	C₇H₅F₄N
Full Name	2-Fluoro-4-(trifluoromethyl)aniline
Molecular Weight	179.11 g/mol
Synonyms	4-Amino-3-fluorobenzotrifluoride, 2-Fluoro-4-(trifluoromethyl)benzenamine
Classification / Family	Fluorinated building block, Heterocycles, Triarylmethanes, APIs

Chemical Structure

Product Details

Purity	98%
Boiling Point	T_b = 55 °C at 0.3 mmHg
Appearance	Colourless liquid

MSDS Documentation

2-Fluoro-4-(trifluoromethyl)aniline MSDS Sheet

Literature and Reviews

Synthesis and in vitro evaluation of 8-pyridinyl=substituted benzo[e]imidazo[2,1-c][1,2,4]triazines as phosphodiesterase 2A inhibitors, R. Ritawidya et al., Molecules, 24, 2791(2019); DOI: 10.3390/molecules24152791.
Silver-catalyzed regioselective 1,6-hydroarylation of para-quinone methides with anilines and phenols, B, Xiong et al., Org. Chem. Front., 9, 3807–3817(2022); DOI: 10.1039/D2QO00541G.
Synthesis and biological evaluation of 2-(3-fluoro-4-nitrophenoxy)-N-phenylacetamide derivatives as novel potenial affordable antitubercular agents, W. Ang et al., Molecules, 17, 2248–2258; DOI: 10.3390/molecules17022248.
Fentanyls continue to replace heroin in the drug arena: the cases of ocfentanil and carfentanil, N. Misailidi et al., Forensic Toxicol., 36, 12–32(2018); DOI: 10.1007/s11419-017-0379-4.
One-pot synthesis of 3-fluoro-4-(trifluoromethyl)quinolines from pentafluoropropen-2-ol and their molecular modification, T. Hosokawa et al., J. Org. Chem., 73(4), 1468–1474(2008); DOI: 10.1021/jo702568z.

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