Bis(4-fluorophenyl)methanol

CAS Number 365-24-2

Chemistry Building Blocks, Fluorinated Building Blocks, Monomers

Bis(4-fluorophenyl)methanol CAS 365-24-2

A fluorinated diphenylmethanol building block

Used as a synthesis intermediate for APIs and macromolecules

Overview
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Bis(4-fluorophenyl)methanol (CAS number 365-24-2), also referred to as 4,4'-difluorobenzhydrol, is a diphenyl methanol building block with two fluorine atoms at the para-position. Bis(4-fluorophenyl)methanol is an important building block for synthesizing antipsychotic drug such as fluspirilene, pimozide and penfluridol. Bis(4-fluorophenyl)methanol is also used in the total synthesis of Tunicamycin V, a homologous nucleoside antibiotic.

Fluspirilene chemical structure — Chemical structure of fluspirilene, an anti-psychotic drug

Bis(4-fluorophenyl)methanol is used to synthesise aromatic polyethers through nucleophilic aromatic substitution. The free hydroxy groups can be further functionalized for graft polymer with 'grafting to' method.

Multiple functional groups

For facile synthesis

Fluorinated benzonitrile building block

For drug discovery and polymer chemistry

Worldwide shipping

Quick and reliable shipping

High purity

>98% High purity

General Information

CAS Number	365-24-2
Chemical Formula	C₁₃H₁₀F₂O
Full Name	4,4'-Difluorobenzhydrol
Molecular Weight	220.22 g/mol
Synonyms	4,4′-Difluorobenzhydrol, Bis(4-fluorophenyl) carbinol, 4,4'-Difluorobenzhydryl alcohol
Classification / Family	Fluorinated building block, APIs, Graft polymers, Functional polymers

Chemical Structure

Product Details

Purity	98%
Melting Point	T_m = 43 – 45 °C
Appearance	White to off-white powder

MSDS Documentation

Bis(4-fluorophenyl)methanol MSDS Sheet

Literature and Reviews

An improved total synthesis of tunicamycin V, K. Mitachi et al., MethodsX, 10, 102095(2023); DOI: 10.1016/j.mex.2023.102095.
Design and synthesis of novel poly (aryl etherketones) containing trifluoromethyl and trifluoromethoxy groups, X. Liu et al., Des. Monomers Polym., 26(1), 140–149(2023); DOI: 10.1080/15685551.2023.2205733.
Preparation and characterization of fluorine-containing aromatic condensation polymers VIII. Aromatic polyether and copolyethers from 2,2-bis(4-hydroxyphenyl)-1,1,1,3,3,3-hexafluoropropane, 2,2-bis(4-hydroxyphenyl)propane, or both and bis(4-fluorophenyl)phenylphosphine oxide, Y. Saegusa et al., Polym. J., 37(6), 399–403(2005); DOI: 10.1295/polymj.37.399.
Synthetic routes to approved drugs containing a spirocycle, N. Moshnenko et al., Molecules, 28, 4209(2023). DOI: 10.3390/molecules28104209.

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