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Bis(4-fluorophenyl)methanol

CAS Number 365-24-2

Chemistry Building Blocks, Fluorinated Building Blocks, Monomers


Product Code B2361-50g
Price $132 ex. VAT

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A fluorinated diphenylmethanol building block

Used as a synthesis intermediate for APIs and macromolecules


Bis(4-fluorophenyl)methanol (CAS number 365-24-2), also referred to as 4,4'-difluorobenzhydrol, is a diphenyl methanol building block with two fluorine atoms at the para-position. Bis(4-fluorophenyl)methanol is an important building block for synthesizing antipsychotic drug such as fluspirilene, pimozide and penfluridol. Bis(4-fluorophenyl)methanol is also used in the total synthesis of Tunicamycin V, a homologous nucleoside antibiotic.

Fluspirilene chemical structure
Chemical structure of fluspirilene, an anti-psychotic drug

Bis(4-fluorophenyl)methanol is used to synthesise aromatic polyethers through nucleophilic aromatic substitution. The free hydroxy groups can be further functionalized for graft polymer with 'grafting to' method.

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated building block

Fluorinated benzonitrile building block

For drug discovery and polymer chemistry

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High purity 365-24-2

High purity

>98% High purity

General Information

CAS Number 365-24-2
Chemical Formula C13H10F2O
Full Name 4,4'-Difluorobenzhydrol
Molecular Weight 220.22 g/mol
Synonyms 4,4′-Difluorobenzhydrol, Bis(4-fluorophenyl) carbinol, 4,4'-Difluorobenzhydryl alcohol
Classification / Family Fluorinated building block, APIs, Graft polymers, Functional polymers

Chemical Structure

Bis(4-fluorophenyl)methanol chemical structure, CAS 365-24-2
Bis(4-fluorophenyl)methanol chemical structure, CAS 365-24-2

Product Details

Purity 98%
Melting Point Tm = 43  45 °C
Appearance White to off-white powder

MSDS Documentation

Bis(4-fluorophenyl)methanolBis(4-fluorophenyl)methanol MSDS Sheet

Literature and Reviews

  1. An improved total synthesis of tunicamycin V, K. Mitachi et al., MethodsX, 10, 102095(2023); DOI: 10.1016/j.mex.2023.102095.
  2. Design and synthesis of novel poly (aryl etherketones) containing trifluoromethyl and trifluoromethoxy groups, X. Liu et al., Des. Monomers Polym., 26(1), 140–149(2023); DOI: 10.1080/15685551.2023.2205733.
  3. Preparation and characterization of fluorine-containing aromatic condensation polymers VIII. Aromatic polyether and copolyethers from 2,2-bis(4-hydroxyphenyl)-1,1,1,3,3,3-hexafluoropropane, 2,2-bis(4-hydroxyphenyl)propane, or both and bis(4-fluorophenyl)phenylphosphine oxide, Y. Saegusa et al., Polym. J., 37(6), 399–403(2005); DOI: 10.1295/polymj.37.399.
  4. Synthetic routes to approved drugs containing a spirocycle, N. Moshnenko et al., Molecules, 28, 4209(2023). DOI: 10.3390/molecules28104209.

To the best of our knowledge the information provided here is accurate. The values provided are typical at the time of manufacture and may vary over time and from batch to batch. Products may have minor cosmetic differences (e.g. to the branding) compared to the photos on our website. All products are for laboratory and research and development use only.

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