4-Fluoro-4′-methoxybenzophenone

A fluorinated benzophenone building block

Used in the synthesis of polyketone esters, fluorenes derivatives and photocatalysts

Specifications | MSDS | Literature and Reviews

4-Fluoro-4′-methoxybenzophenone (CAS number 345-89-1) is a benzophenone building block with fluorine and methoxy groups on both para-positions. Benzophenone derivatives are photosensitive, thus, 4-fluoro-4′-methoxybenzophenone is applied as a photocatalyst for photochemical fluorination with sulfur hexafluoride as the fluorine source. The photocatalytic reaction is performed under a 365 nm UV radiation, resulting in a moderated 56% yield.

4-Fluoro-4′-methoxybenzophenone is also utilised in the preparation of fluorenone, a fluorene derivative with a ketone on the 9-position. Fluorenone finds widespread applications in pharmaceutical industry and organic electronics. The reaction involves a palladium-catalysed dehydrogenative cyclisation, yielding up to 90%.

Multiple functional groups

For facile synthesis

Fluorinated benzophenone building block

for organic electronics and photocatalytic chemistry research

Worldwide shipping

Quick and reliable shipping

High purity

>98% High purity

General Information

Chemical Structure

Product Details

MSDS Documentation

4-Fluoro-4′-methoxybenzophenone MSDS Sheet

Literature and Reviews

1. Polymerisation and related reactions involving nucleophilic aromatic substitution. Part 1. The rates of reaction of substituted 4-halogenobenzophenones with the potassium salts of substituted 4-hydroxybenzophenones, J, Ridd et al., J. Chem. Soc., Perkin Trans. 2, 1729–1734(1988); DOI: 10.1039/P29880001729.
2. Soluble telechelic polycondensation poly(ether ketones): synthesis and characterization, A. Benhalima et al., Macromol. Chem. Phys., 220, 1900234(2019); DOI: 10.1002/macp.201900234.
3. A perspective on synthesis and applications of fluorenones, S. Patel et al., ChemistrySelect, 5, 10673–10691(2020); DOI: 10.1002/slct.202002695.

View Literature and Reviews