2-Fluorobiphenyl

CAS Number 321-60-8

Chemistry Building Blocks, Fluorinated Building Blocks, Materials, Monomers, Non-Heterocyclic Building Blocks

A fluorinated biphenyl building block

A synthesis intermediate for microporous organic polymers and active pharmaceutical ingredients

Specifications | MSDS | Literature and Reviews

2-Fluorobiphenyl (CAS number 321-60-8), is a ortho-fluorinated phenylbenzene. It is commonly used in the synthesis of active pharmaceutical ingredients (APIs). Flurbiprofen, a nonsteroidal anti-inflammatory drug, contains 2-fluorobiphenyl in its chemical structure. 2-Fluorobiphenyl is also applied in organic synthesis of arylation reactions. It serves as a ¹⁹F NMR probe, facilitating the determination of molecular structures.

2-Fluorobiphenyl also finds its application in the synthesis of microporous organic polymers (MOPs). The MOPs is synthesized through Friedel-Crafts acylation, exhibiting a surface area of 917 m²/g. The resulting MOPs are used in xenon/krypton gas separation and the encapsulation of phase change materials for thermal energy storage.

Multiple functional groups

For facile synthesis

Fluorinated biphenyl building block

for drug discovery, ligands, and microporous organic polymers

Low Cost

Competitively priced, high quality product

High purity

>98% High purity

General Information

CAS Number	321-60-8
Chemical Formula	C₁₂H₉F
Full Name	2-Fluorobiphenyl
Molecular Weight	172.20 g/mol
Synonyms	1-Fluoro-2-phenyl-benzene, 2-Fluoro-1,1'-biphenyl
Classification / Family	Fluorinated building blocks, Biphenyl building blocks, Ligands, MOPs, NMR probes, APIs

Chemical Structure

Product Details

Purity	98%
Melting Point	T_m = 71 °C – 74 °C
Appearance	White crystals

MSDS Documentation

2-Fluorobiphenyl MSDS Sheet

Literature and Reviews

Simple biphenyl derived porous aromatic frameworks with attractive xenon/krypton separation, Z. Li et al., Chem. Phys. Lett., 820, 140462 (2023); DOI: 10.1016/j.cplett.2023.140462.
Fluorinated microporous organic polymers for enhanced thermal energy storage, X. Jiang et al., Microporous Mesoporous Mater., 341, 112058 (2023); DOI: 10.1016/j.micromeso.2022.112058.
Site-selective and versatile aromatic C−H functionalization by thianthrenation, F. Berger et al., Nature, 567, 223–228 (2019); DOI: 10.1038/s41586-019-0982-0.

Parameterization of phosphine ligands demonstrates enhancement of nickel catalysis via remote steric effects, K. Wu et al., Nat. Chem., 9 (8), 779–784 (2017); DOI: 10.1038/nchem.2741.