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Product Code B3461-10g
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A fluorinated biphenyl building block

A synthesis intermediate for microporous organic polymers and active pharmaceutical ingredients


2-Fluorobiphenyl (CAS number 321-60-8), is a ortho-fluorinated phenylbenzene. It is commonly used in the synthesis of active pharmaceutical ingredients (APIs). Flurbiprofen, a nonsteroidal anti-inflammatory drug, contains 2-fluorobiphenyl in its chemical structure. 2-Fluorobiphenyl is also applied in organic synthesis of arylation reactions. It serves as a 19F NMR probe, facilitating the determination of molecular structures.

2-Fluorobiphenyl also finds its application in the synthesis of microporous organic polymers (MOPs). The MOPs is synthesized through Friedel-Crafts acylation, exhibiting a surface area of 917 m2/g. The resulting MOPs are used in xenon/krypton gas separation and the encapsulation of phase change materials for thermal energy storage.

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated biphenyl building block

Fluorinated biphenyl building block

for drug discovery, ligands, and microporous organic polymers

competitively priced 321-60-8

Low Cost

Competitively priced, high quality product

High purity 321-60-8

High purity

>98% High purity

General Information

CAS Number 321-60-8
Chemical Formula C12H9F
Full Name 2-Fluorobiphenyl
Molecular Weight 172.20 g/mol
Synonyms 1-Fluoro-2-phenyl-benzene, 2-Fluoro-1,1'-biphenyl
Classification / Family Fluorinated building blocks, Biphenyl building blocks, Ligands, MOPs, NMR probes, APIs

Chemical Structure

2-Fluorobiphenyl chemical structure, CAS 321-60-8
2-Fluorobiphenyl chemical structure, CAS 321-60-8

Product Details

Purity 98%
Melting Point Tm = 71 °C – 74 °C
Appearance White crystals

MSDS Documentation

2-Fluorobiphenyl2-Fluorobiphenyl MSDS Sheet

Literature and Reviews

  1. Simple biphenyl derived porous aromatic frameworks with attractive xenon/krypton separation, Z. Li et al., Chem. Phys. Lett., 820, 140462 (2023); DOI: 10.1016/j.cplett.2023.140462.
  2. Fluorinated microporous organic polymers for enhanced thermal energy storage, X. Jiang et al., Microporous Mesoporous Mater., 341, 112058 (2023); DOI: 10.1016/j.micromeso.2022.112058.
  3. Site-selective and versatile aromatic C−H functionalization by thianthrenation, F. Berger et al., Nature, 567, 223–228 (2019); DOI: 10.1038/s41586-019-0982-0.
  4. Parameterization of phosphine ligands demonstrates enhancement of nickel catalysis via remote steric effects, K. Wu et al., Nat. Chem., 9 (8), 779–784 (2017); DOI: 10.1038/nchem.2741.

To the best of our knowledge the information provided here is accurate. The values provided are typical at the time of manufacture and may vary over time and from batch to batch. Products may have minor cosmetic differences (e.g. to the branding) compared to the photos on our website. All products are for laboratory and research and development use only.

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