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Product Code B2441-10g
Price £80 ex. VAT

A fluorinated benzhydrylpiperazine building block

Used as a synthesis intermediate for APIs in medicinal chemistry


Specifications | MSDS | Literature and Reviews


1-Bis(4-fluorophenyl)methyl piperazine (CAS number 27469-60-9), also referred to as difluorobenzhydrylpiperazine, has a piperazine connecting to a diphenylmethane with two fluorine atoms at para-positions. 1-Bis(4-fluorophenyl)methyl piperazine appears in synthesis of drugs such as flunarizine and lomerizine. The diphenylpiperazine drugs are typically classified as calcium antagonists (calcium channel blockers) and used clinically for the treatment of migraines. The synthesis involves a one-step reaction of 1-bis(4-fluorophenyl)methyl piperazine with the halogenated analogues of the second fragments via nucleophilic substitution.

1-Bis(4-fluorophenyl)methyl piperazine also involves in synthesis of piperazinylacetamides for anticancer drugs, with half maxima growth inhibitory concentration (GI50) of 4.36 µM.

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated building block

Fluorinated benzhydrylpiperazine building block

For drug discovery, medicinal chemistry and biochemistry research

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High purity 27469-60-9

High purity

>98% High purity

General Information


CAS Number 27469-60-9
Chemical Formula C17H18F2N2
Full Name 1-Bis(4-fluorophenyl)methyl piperazine
Molecular Weight 288.34 g/mol
Synonyms 1-(4,4'-Difluorobenzhydryl)piperazine, 1-(4,4'-Difluorodiphenylmethyl)piperazine, 4,4'-Difluorobenzhydrylpiperazine
Classification / Family Fluorinated building block, Heterocyclic building block, APIs, antimicrobials

Chemical Structure


1-Bis(4-fluorophenyl)methyl piperazine chemical structure, CAS 27469-60-9.
1-Bis(4-fluorophenyl)methyl piperazine chemical structure, CAS 27469-60-9

Product Details


Purity 98%
Melting Point Tm = 88 °C – 92 °C
Appearance White powder

MSDS Documentation


1-Bis(4-fluorophenyl)methyl piperazine1-Bis(4-fluorophenyl)methyl piperazine MSDS Sheet

Literature and Reviews


  1. (4-(Bis(4-Fluorophenyl)methyl)piperazin-1-yl)(cyclohexyl) methanone hydrochloride (LDK1229): a new cannabinoid CB1 receptor inverse agonist from the class of benzhydryl piperazine analogs, M. Mahmoud et al., Mol. Pharmacol., 87, 197–206(2015); DOI: 10.1124/mol.114.095471.
  2. Mechanistic modelling of monoglyceride lipase covalent modification elucidates the role of leaving group expulsion and discriminations inhibitors with high and low potency, F. Galvani et al., J. Chem. Inf. Model., 62, 2771–2787(2022); DOI: 10.1021/acs.jcim.2c00140.
  3. Synthesis and biological evaluation of novel benzhydrylpiperazine-coupled nitrobenzenesulfonamide hybrids, V. Murthy et al., ACS Omega 2021, 6, 9731–9740; DOI: 10.1021/acsomega.1c00369.
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