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Product Code B3241-5g
Price $68 ex. VAT

A fluorinated building blocks

Serves as a synthesis intermediate for APIs and dyes


Specifications | MSDS | Literature and Reviews


4-Bromo-3-fluorobenzonitrile (CAS 133059-44-6) is a benzonitrile derivative with bromide and fluoride functional groups. Due to its multiple functional groups, 4-bromo-3-fluorobenzonitrile is employed as molecular scaffold for active pharmaceutical ingredients (APIs). The bromo-substituent allows 4-bromo-3-fluorobenzonitrile to undergo palladium-catalysed cross-coupling reactions. Antimutagenic drugs known as bichalcophene fluorobenzamidines are prepared from 4-bromo-3-fluorobenzonitrile. The synthesis begins with a Stille coupling reaction followed by the conversion of nitrile to amidine using lithium bis(trimethylsilyl)amide. These antimutagens demonstrate a 69% reduction in the mutation frequency caused by the binding of azide to DNA.

4-Bromo-3-fluorobenzonitrile is also employed in the preparation of persistent room-temperature phosphorescent dyes. These dyes, derived from carbazole, exhibit a high quantum yield of up to 22%.

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated benzonitrile building block

Fluorinated benzonitrile building block

For drug discovery, medicinal chemistry, and phosphorescent dyes

competitively priced 133059-44-6

Low Cost

Competitively priced, high quality product

High purity 133059-44-6

High purity

>98% High purity

General Information


CAS Number 133059-44-6
Chemical Formula C7H3BrFN
Full Name 4-Bromo-3-fluorobenzonitrile
Molecular Weight 200.01 g/mol
Synonyms 4-Cyano-2-fluorobromobenzene, 3-Fluoro-4-bromocyanobenzene
Classification / Family Fluorinated building blocks, Non-heterocyclic building blocks, Brominated building blocks, Benzonitrile building blocks, APIs, Phosphorescent dyes

Chemical Structure


4-Bromo-3-fluorobenzonitrile chemical structure, CAS 133059-44-6.
4-Bromo-3-fluorobenzonitrile chemical structure, CAS 133059-44-6

Product Details


Purity 98%
Melting Point Tm = 92 °C – 97 °C
Appearance White Powder/Crystals

MSDS Documentation


4-Bromo-3-fluorobenzonitrile4-Bromo-3-fluorobenzonitrile MSDS Sheet

Literature and Reviews


  1. The transition-metal-catalyst-free oxidative homocoupling of organomanganese reagents prepared by the insertion of magnesium into organic halides in the presence of MnCl2•2LiCl, Z. Peng et al., Org. Biomol. Chem., 12, 7800–7809 (2014); DOI: 10.1039/C4OB01235F.
  2. Evaluation of the biological activity of novel monocationic fluoroaryl-2,2′-bichalcophenes and their analogues, W. Hassin et al., Drug Des. Devel. Ther., 20, 963–972 (2014); DOI: 10.2147/DDDT.S66469.
  3. Organic persistent room temperature phosphorescence enabled by carbazole impurity, A. Brannan et al., Front. Chem., 10, 1008658 (2023); DOI: 10.3389/fchem.2022.1008658.

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