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Product Code B3241-5g
Price $63 ex. VAT

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A fluorinated building blocks

Serves as a synthesis intermediate for APIs and dyes


4-Bromo-3-fluorobenzonitrile (CAS 133059-44-6) is a benzonitrile derivative with bromide and fluoride functional groups. Due to its multiple functional groups, 4-bromo-3-fluorobenzonitrile is employed as molecular scaffold for active pharmaceutical ingredients (APIs). The bromo-substituent allows 4-bromo-3-fluorobenzonitrile to undergo palladium-catalysed cross-coupling reactions. Antimutagenic drugs known as bichalcophene fluorobenzamidines are prepared from 4-bromo-3-fluorobenzonitrile. The synthesis begins with a Stille coupling reaction followed by the conversion of nitrile to amidine using lithium bis(trimethylsilyl)amide. These antimutagens demonstrate a 69% reduction in the mutation frequency caused by the binding of azide to DNA.

4-Bromo-3-fluorobenzonitrile is also employed in the preparation of persistent room-temperature phosphorescent dyes. These dyes, derived from carbazole, exhibit a high quantum yield of up to 22%.

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated benzonitrile building block

Fluorinated benzonitrile building block

For drug discovery, medicinal chemistry, and phosphorescent dyes

competitively priced 133059-44-6

Low Cost

Competitively priced, high quality product

High purity 133059-44-6

High purity

>98% High purity

General Information

CAS Number 133059-44-6
Chemical Formula C7H3BrFN
Full Name 4-Bromo-3-fluorobenzonitrile
Molecular Weight 200.01 g/mol
Synonyms 4-Cyano-2-fluorobromobenzene, 3-Fluoro-4-bromocyanobenzene
Classification / Family Fluorinated building blocks, Non-heterocyclic building blocks, Brominated building blocks, Benzonitrile building blocks, APIs, Phosphorescent dyes

Chemical Structure

4-Bromo-3-fluorobenzonitrile chemical structure, CAS 133059-44-6.
4-Bromo-3-fluorobenzonitrile chemical structure, CAS 133059-44-6

Product Details

Purity 98%
Melting Point Tm = 92 °C – 97 °C
Appearance White Powder/Crystals

MSDS Documentation

4-Bromo-3-fluorobenzonitrile4-Bromo-3-fluorobenzonitrile MSDS Sheet

Literature and Reviews

  1. The transition-metal-catalyst-free oxidative homocoupling of organomanganese reagents prepared by the insertion of magnesium into organic halides in the presence of MnCl2•2LiCl, Z. Peng et al., Org. Biomol. Chem., 12, 7800–7809 (2014); DOI: 10.1039/C4OB01235F.
  2. Evaluation of the biological activity of novel monocationic fluoroaryl-2,2′-bichalcophenes and their analogues, W. Hassin et al., Drug Des. Devel. Ther., 20, 963–972 (2014); DOI: 10.2147/DDDT.S66469.
  3. Organic persistent room temperature phosphorescence enabled by carbazole impurity, A. Brannan et al., Front. Chem., 10, 1008658 (2023); DOI: 10.3389/fchem.2022.1008658.
  4. Synthesis and antiprotozoal activity of dicationic 2,6-diphenylpyrazines and aza-analogues, L. Hu et al., Bioorg. Med. Chem., 21 (21), 6732–6741 (2013); DOI: 10.1016/j.bmc.2013.08.006.

To the best of our knowledge the information provided here is accurate. The values provided are typical at the time of manufacture and may vary over time and from batch to batch. Products may have minor cosmetic differences (e.g. to the branding) compared to the photos on our website. All products are for laboratory and research and development use only.

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