4-Amino-2-(trifluoromethyl)pyridine

CAS Number 147149-98-2

Chemistry Building Blocks, Fluorinated Building Blocks, Heterocyclic Building Blocks, Monomers

4-Amino-2-(trifluoromethyl)pyridine MSDS

4-Amino-2-(trifluoromethyl)pyridine CAS 147149-98-2

A fluorinated pyridine building block

Used for the synthesis of APIs in cancer treatment and ligands for chemical reactions

Overview
Related Products

4-Amino-2-(trifluoromethyl)pyridine (CAS number 147149-98-2) has an amine and a trifluoromethyl group substituted on its pyridine core. 4-Amino-2-(trifluoromethyl)pyridine are involved in many syntheses of active pharmaceutical ingredients (APIs), such as naporafenib, a RAF inhibitor used in the treatment of RAF-driven cancers. 4-Amino-2-(trifluoromethyl)pyridine can also be used for synthesising pyridine-based ligands to stabilise hypervalent iodine which is applied in a wide range of synthetic transformations.

4-Amino-2-(trifluoromethyl)pyridine can undergo a Chichibabin reaction to introduce an additional amine group in the para-position. The resulting product is employed in the synthesis of oral checkpoint kinase inhibitor for immunotherapy.

Multiple functional groups

For facile synthesis

Fluorinated building block

For drug discovery, medicinal chemistry and biochemistry research

Worldwide shipping

Quick and reliable shipping

High purity

>98% High purity

General Information

CAS Number	147149-98-2
Chemical Formula	C₆H₅F₃N₂
Full Name	2-(Trifluoromethyl)-4-pyridinamine
Molecular Weight	162.11 g/mol
Synonyms	2-(Trifluoromethyl)pyridin-4-amine, 2-Trifluoromethyl-4-amino-pyridine
Classification / Family	Fluorinated building blocks, Heterocyclic building blocks, Pyridine building blocks, APIs, Ligands

Chemical Structure

Product Details

Purity	98%
Melting Point	T_m = 58 °C – 62 °C
Appearance	White crystals

MSDS Documentation

4-Amino-2-(trifluoromethyl)pyridine MSDS Sheet

Literature and Reviews

Multiparameter lead optimization to give an oral checkpoint kinase 1 (CHK1) inhibitor clinical candidate: (R)‑5-((4-((morpholin-2-ylmethyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)pyrazine-2-carbonitrile (CCT245737), J. Osborne et al., J. Med. Chem., 59, 5221–5237(2016); DOI: 10.1021/acs.jmedchem.5b01938.
Greener and efficient synthesis of some novel substituted azitidinones with 4-amino pyridine via heterogenous catalyst, K. Avasthi et al., J. Appl. Chem., 3(5), 1899–1906(2014); ISSN: 2278-1862.
Preparation of (bis)cationic nitrogen-ligated I(III) reagents: synthesis of [(pyridine)₂IPh](OTF)₂ and [(4-CF₃-pyridine)₂IPh](OTF)₂, B. Hoblos et al., Organic Synth., 98, 391–406(2021); DOI: 10.15227/orgsyn.098.0391.
Protomer selectivity of type II RAF inhibitors within the RAS/RAF complex, J. Vasta et al., Cell Chem. Biol., 30, 1–12(2023); DOI: 10.1016/j.chembiol.2023.07.019.

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