4-Amino-2-(trifluoromethyl)pyridine
CAS Number 147149-98-2
Chemistry Building Blocks, Fluorinated Building Blocks, Heterocyclic Building Blocks, Materials, Monomers
A fluorinated pyridine building block
Used for the synthesis of APIs in cancer treatment and ligands for chemical reactions
Specifications | MSDS | Literature and Reviews
4-Amino-2-(trifluoromethyl)pyridine (CAS number 147149-98-2) has an amine and a trifluoromethyl group substituted on its pyridine core. 4-Amino-2-(trifluoromethyl)pyridine are involved in many syntheses of active pharmaceutical ingredients (APIs), such as naporafenib, a RAF inhibitor used in the treatment of RAF-driven cancers. 4-Amino-2-(trifluoromethyl)pyridine can also be used for synthesising pyridine-based ligands to stabilise hypervalent iodine which is applied in a wide range of synthetic transformations.
4-Amino-2-(trifluoromethyl)pyridine can undergo a Chichibabin reaction to introduce an additional amine group in the para-position. The resulting product is employed in the synthesis of oral checkpoint kinase inhibitor for immunotherapy.
Multiple functional groups
For facile synthesis
Fluorinated building block
For drug discovery, medicinal chemistry and biochemistry research
Worldwide shipping
Quick and reliable shipping
High purity
>98% High purity
General Information
| CAS Number | 147149-98-2 |
| Chemical Formula | C6H5F3N2 |
| Full Name | 2-(Trifluoromethyl)-4-pyridinamine |
| Molecular Weight | 162.11 g/mol |
| Synonyms | 2-(Trifluoromethyl)pyridin-4-amine, 2-Trifluoromethyl-4-amino-pyridine |
| Classification / Family | Fluorinated building blocks, Heterocyclic building blocks, Pyridine building blocks, APIs, Ligands |
Chemical Structure
Product Details
| Purity | 98% |
| Melting Point | Tm = 58 °C – 62 °C |
| Appearance | White crystals |
MSDS Documentation
4-Amino-2-(trifluoromethyl)pyridine MSDS Sheet
Literature and Reviews
- Multiparameter lead optimization to give an oral checkpoint kinase 1 (CHK1) inhibitor clinical candidate: (R)‑5-((4-((morpholin-2-ylmethyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)pyrazine-2-carbonitrile (CCT245737), J. Osborne et al., J. Med. Chem., 59, 5221–5237(2016); DOI: 10.1021/acs.jmedchem.5b01938.
- Greener and efficient synthesis of some novel substituted azitidinones with 4-amino pyridine via heterogenous catalyst, K. Avasthi et al., J. Appl. Chem., 3(5), 1899–1906(2014); ISSN: 2278-1862.
- Preparation of (bis)cationic nitrogen-ligated I(III) reagents: synthesis of [(pyridine)2IPh](OTF)2 and [(4-CF3-pyridine)2IPh](OTF)2, B. Hoblos et al., Organic Synth., 98, 391–406(2021); DOI: 10.15227/orgsyn.098.0391.