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Product Code B2961-1g
Price $63 ex. VAT

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A fluorinated pyridine building block

Used for the synthesis of APIs in cancer treatment and ligands for chemical reactions


4-Amino-2-(trifluoromethyl)pyridine (CAS number 147149-98-2) has an amine and a trifluoromethyl group substituted on its pyridine core. 4-Amino-2-(trifluoromethyl)pyridine are involved in many syntheses of active pharmaceutical ingredients (APIs), such as naporafenib, a RAF inhibitor used in the treatment of RAF-driven cancers. 4-Amino-2-(trifluoromethyl)pyridine can also be used for synthesising pyridine-based ligands to stabilise hypervalent iodine which is applied in a wide range of synthetic transformations.

4-Amino-2-(trifluoromethyl)pyridine can undergo a Chichibabin reaction to introduce an additional amine group in the para-position. The resulting product is employed in the synthesis of oral checkpoint kinase inhibitor for immunotherapy.

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated building block

Fluorinated building block

For drug discovery, medicinal chemistry and biochemistry research

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High purity

High purity

>98% High purity

General Information

CAS Number 147149-98-2
Chemical Formula C6H5F3N2
Full Name 2-(Trifluoromethyl)-4-pyridinamine
Molecular Weight 162.11 g/mol
Synonyms 2-(Trifluoromethyl)pyridin-4-amine, 2-Trifluoromethyl-4-amino-pyridine
Classification / Family Fluorinated building blocks, Heterocyclic building blocks, Pyridine building blocks, APIs, Ligands

Chemical Structure

4-Amino-2-(trifluoromethyl)pyridine chemical structure, CAS 147149-98-2.
4-Amino-2-(trifluoromethyl)pyridine chemical structure, CAS 147149-98-2

Product Details

Purity 98%
Melting Point Tm = 58 °C – 62 °C
Appearance White crystals

MSDS Documentation

4-Amino-2-(trifluoromethyl)pyridine4-Amino-2-(trifluoromethyl)pyridine MSDS Sheet

Literature and Reviews

  1. Multiparameter lead optimization to give an oral checkpoint kinase 1 (CHK1) inhibitor clinical candidate: (R)‑5-((4-((morpholin-2-ylmethyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)pyrazine-2-carbonitrile (CCT245737), J. Osborne et al., J. Med. Chem., 59, 5221–5237(2016); DOI: 10.1021/acs.jmedchem.5b01938.
  2. Greener and efficient synthesis of some novel substituted azitidinones with 4-amino pyridine via heterogenous catalyst, K. Avasthi et al., J. Appl. Chem., 3(5), 1899–1906(2014); ISSN: 2278-1862.
  3. Preparation of (bis)cationic nitrogen-ligated I(III) reagents: synthesis of [(pyridine)2IPh](OTF)2 and [(4-CF3-pyridine)2IPh](OTF)2, B. Hoblos et al., Organic Synth., 98, 391–406(2021); DOI: 10.15227/orgsyn.098.0391.
  4. Protomer selectivity of type II RAF inhibitors within the RAS/RAF complex, J. Vasta et al., Cell Chem. Biol., 30, 1–12(2023); DOI: 10.1016/j.chembiol.2023.07.019.

To the best of our knowledge the information provided here is accurate. The values provided are typical at the time of manufacture and may vary over time and from batch to batch. Products may have minor cosmetic differences (e.g. to the branding) compared to the photos on our website. All products are for laboratory and research and development use only.

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