4-Fluoro-3-methylbenzoic acid

CAS Number 403-15-6

Chemistry Building Blocks, Fluorinated Building Blocks, Monomers, Non-Heterocyclic Building Blocks

4-Fluoro-3-methylbenzoic acid CAS 403-15-6

A fluorinated benzoic acid building block

For the synthesis of APIs

Overview
Related Products

4-Fluoro-3-methylbenzoic acid (CAS number 403-15-6), is a meta-toluic acid with a fluoride group at the 4-position. 4-Fluoro-3-methylbenzoic acid serves as a versatile building block for the synthesis of active pharmaceutical ingredients (APIs), as its functional group can be directly used or easily converted to alternative functional groups. The carboxylic acid group of 4-fluoro-3-methylbenzoic acid enables it to be attached to molecular scaffolds. Alternatively, it can be reduced to a hydroxy/aldehyde group for other type of reactions. The methyl group can be functionalised by bromide through a benzylic bromination reaction. The resulting brominated product can then be applied in the synthesis of bicyclic heterocycles.

An analogue of imidazopyridine based on 4-fluoro-3-methylbenzoic acid exhibits a potency of 0.1 nM as an anticoccidial agent.

Multiple functional groups

For facile synthesis

Fluorinated benzoic acid building block

For drug discovery, medicinal chemistry, and biochemistry

Low Cost

Competitively priced, high quality product

High purity

>97% High purity

General Information

CAS Number	403-15-6
Chemical Formula	C₈H₇FO₂
Full Name	4-Fluoro-3-methylbenzoic acid
Molecular Weight	154.14 g/mol
Synonyms	4-Fluoro-m-toluic acid
Classification / Family	Fluorinated building block, Benzoic acid building blocks, APIs

Chemical Structure

Product Details

Purity	97%
Melting Point	T_m = 164 °C – 168 °C
Appearance	White powder

MSDS Documentation

4-Fluoro-3-methylbenzoic acid MSDS Sheet

Literature and Reviews

Improved loading and cleavage methods for solid-phase synthesis using chlorotrityl resins: synthesis and testing of a library of 144 discrete chemicals and potential farnesyltransferase inhibitors, J Park et al., J. Comb. Chem., 6 (3), 407–413 (2004); DOI: 10.1021/cc0340729.
Enantiospecific synthesis of SB 214857, a potent, orally active nonpeptide fibrinogen receptor antagonist, W. Miller et al., Tetrahedron Lett., 36 (52), 9433–9436 (1995); DOI: 10.1016/0040-4039(95)02054-3.
Structure-based design, synthesis and biological evaluation of highly selective and potent G protein-coupled receptor kinase 2 inhibitors, H. Waldschmidt et al., J. Med. Chem., 59 (8), 3793–3807 (2016); DOI: 10.1021/acs.jmedchem.5b02000.
Synthesis and biological activity of imidazopyridine anticoccidial agents: part I, A. Scribner et al., Eur. J. Med. Chem., 42, 1334–1357 (2007); DOI: 10.1016/j.ejmech.2007.02.006.

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