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Product Code B2711-5g
Price $100 ex. VAT

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A fluorinated o-aminobenzonitrile

Used as a synthetic precursor for heterocycles in the applications of APIs and ligands


2-Amino-5-fluorobenzonitrile (CAS number 61272-77-3) possesses multiple functional groups, including an amine, a nitrile and a fluoride. The ortho-positioning of the amine and nitrile substituents makes 2-amino-5-fluorobenzonitrile an ideal precursor for synthesising heterocyclic compounds. 2-Amino-5-fluorobenzonitrile reacts with aminoethanol derivatives catalysed by zinc chloride, yielding oxazoline ligands for use in Cu-catalysed enantioselective nitroaldol reactions. Through its reaction with cyclic ketone in Friedländer reaction, 2-amino-5-fluorobenzonitrile serves as a precursor for tacrine derivatives. In the case of synthesising quinazoline/quinazolinone derivatives, the reaction of 2-amino-5-fluorobenzonitrile with cyclic ketones derivatives occurs under basic condition.

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated building block

Fluorinated benzonitrile/aniline building block

For organometallic catalysis, medicinal chemistry and biochemistry research

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High purity 61272-77-3

High purity

>97% High purity

General Information

CAS Number 61272-77-3
Chemical Formula C7H5FN2
Full Name 2-Amino-5-fluorobenzonitrile
Molecular Weight 136.13 g/mol
Synonyms 2-Amino-5-fluorobenzenecarbonitrile, 2-Cyano-4-fluoroaniline
Classification / Family Fluorinated building blocks, Aniline building blocks, Benzonitrile building blocks, APIs, Heterocycles, Ligands

Chemical Structure

2-Amino-5-fluorobenzonitrile chemical structure, CAS 61272-77-3.
2-Amino-5-fluorobenzonitrile chemical structure, CAS 61272-77-3

Product Details

Purity 97%
Melting Point Tm = 92 °C – 96 °C
Appearance Grey powder

MSDS Documentation

2-Amino-5-fluorobenzonitrile2-Amino-5-fluorobenzonitrile MSDS Sheet

Literature and Reviews

  1. Structure-activity relationships of dually-acting acetylcholinesterase inhibitors derived from tacrine on N-methyl-D-Aspartate receptors, L. Gorecki et al., Eur. J. Med. Chem., 219, 113434(2021); DOI: 10.1016/j.ejmech.2021.113434.
  2. Cobalt-catalyzed tandem transformation of 2-aminobenzonitriles to quinazolinones using hydration and dehydrogenative coupling strategy, A. Samin et al., J. Org. Chem., 85, 11359–11367(2020); DOI: 10.1021/acs.joc.0c01307.
  3. Chiral pyridine oxazoline and 1,2,4‑triazine oxazoline ligands incorporating electron‑withdrawing substituents and their application in the Cu‑catalyzed enantioselective nitroaldol reaction, E. Wolińska et al., Monatsh. Chem., 153, 245–256(2022); DOI: 10.1007/s00706-022-02893-0.
  4. Synthesis of quinazoline-2,4(1H,3H)-diones from carbon dioxide and 2-aminobenzonitriles using [Bmim]OH as a homogeneous recyclable catalyst, Y. Patil et al., Catal., 148(3-4), 355–360(2009); DOI: 10.1016/j.cattod.2009.06.010.

To the best of our knowledge the information provided here is accurate. The values provided are typical at the time of manufacture and may vary over time and from batch to batch. Products may have minor cosmetic differences (e.g. to the branding) compared to the photos on our website. All products are for laboratory and research and development use only.

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