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CAS Number 77326-36-4

Chemistry Building Blocks, Fluorinated Building Blocks, Monomers

Product Code B2651-25g
Price $113 ex. VAT

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A fluorinated benzonitrile building block

Used as a precursor for synthesising bicyclic heterocycles in medicinal chemistry research

2-Amino-6-fluorobenzonitrile (CAS number 77326-36-4) is a synthesis intermediate bearing multiple functional groups including a fluoride, a nitrile and an amine. The ortho-position of amine and nitrile groups in 2-amino-6-fluorobenzonitrile is ideal for synthesising quinazolines. Quinazoline derivatives are bicyclic heterocycles used for antimalaria and anticancer treatments, such as Gefitinib, Lapatinib, Erlotinib and Afatinib.

2-Amino-6-fluorobenzonitrile is also used to synthesise aminoquinoline derivatives by reacting with ketones. Tacrine derivatives, cholinesterase inhibitors for Alzheimer's disease, can be obtained with such method.

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated building block

Fluorinated benzonitrile/aniline building block

For drug discovery, medicinal chemistry and biochemistry research

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High purity 77326-36-4

High purity

>98% High purity

General Information

CAS Number 77326-36-4
Chemical Formula C7H5FN2
Full Name 2-Amino-6-fluorobenzonitrile
Molecular Weight 136.13 g/mol
Synonyms 2-Cyano-3-fluoroaniline, 6-Fluoro-2-aminobenzonitrile
Classification / Family Fluorinated building blocks, Aniline building blocks, APIs, Heterocycles

Chemical Structure

2-Amino-6-fluorobenzonitrile chemical structure, CAS 77326-36-4.
2-Amino-6-fluorobenzonitrile chemical structure, CAS 77326-36-4

Product Details

Purity 98%
Melting Point Tm = 127 °C – 131 °C
Appearance Off-white powder

MSDS Documentation

2-Amino-6-fluorobenzonitrile2-Amino-6-fluorobenzonitrile MSDS Sheet

Literature and Reviews

  1. Huprines as a new family of dual acting trypanocidal–antiplasmodial agents, J. Defaux et al., Bioorg. Med. Chem., 19, 1702–1707(2011); DOI: 10.1016/j.bmc.2011.01.028.
  2. Fluorine-containing heterocycles: XVIII.* monofluoroderivatives of quinazolines and 1,3-benzothiazin-4-ones, E. Nosova et al., Russ. J. Org. Chem., 45, 904–912(2009); DOI: 10.1134/S1070428009060189.
  3. Synthesis of 5- and 7-fluoroquinazolin-4(1H)-ones, A. Layeva et al., Russ. Chem. Bull., 56, 1821–1827(2007); DOI: 10.1007/s11172-007-0283-x.
  4. An expedient synthesis of oxazepino and oxazocino quinazolines, A. Hensbergen et al., Tetrahedron Lett., 56(46), 6478–6483(2015); DOI: 10.1016/j.tetlet.2015.10.008.

To the best of our knowledge the information provided here is accurate. The values provided are typical at the time of manufacture and may vary over time and from batch to batch. Products may have minor cosmetic differences (e.g. to the branding) compared to the photos on our website. All products are for laboratory and research and development use only.

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