2-Amino-6-fluorobenzonitrile

CAS Number 77326-36-4

Chemistry Building Blocks, Fluorinated Building Blocks, Monomers

2-Amino-6-fluorobenzonitrile CAS 77326-36-4

A fluorinated benzonitrile building block

Used as a precursor for synthesising bicyclic heterocycles in medicinal chemistry research

Overview
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2-Amino-6-fluorobenzonitrile (CAS number 77326-36-4) is a synthesis intermediate bearing multiple functional groups including a fluoride, a nitrile and an amine. The ortho-position of amine and nitrile groups in 2-amino-6-fluorobenzonitrile is ideal for synthesising quinazolines. Quinazoline derivatives are bicyclic heterocycles used for antimalaria and anticancer treatments, such as Gefitinib, Lapatinib, Erlotinib and Afatinib.

2-Amino-6-fluorobenzonitrile is also used to synthesise aminoquinoline derivatives by reacting with ketones. Tacrine derivatives, cholinesterase inhibitors for Alzheimer's disease, can be obtained with such method.

Multiple functional groups

For facile synthesis

Fluorinated benzonitrile/aniline building block

For drug discovery, medicinal chemistry and biochemistry research

Worldwide shipping

Quick and reliable shipping

High purity

>98% High purity

General Information

CAS Number	77326-36-4
Chemical Formula	C₇H₅FN₂
Full Name	2-Amino-6-fluorobenzonitrile
Molecular Weight	136.13 g/mol
Synonyms	2-Cyano-3-fluoroaniline, 6-Fluoro-2-aminobenzonitrile
Classification / Family	Fluorinated building blocks, Aniline building blocks, APIs, Heterocycles

Chemical Structure

Product Details

Purity	98%
Melting Point	T_m = 127 °C – 131 °C
Appearance	Off-white powder

MSDS Documentation

2-Amino-6-fluorobenzonitrile MSDS Sheet

Literature and Reviews

Huprines as a new family of dual acting trypanocidal–antiplasmodial agents, J. Defaux et al., Bioorg. Med. Chem., 19, 1702–1707(2011); DOI: 10.1016/j.bmc.2011.01.028.
Fluorine-containing heterocycles: XVIII.* monofluoroderivatives of quinazolines and 1,3-benzothiazin-4-ones, E. Nosova et al., Russ. J. Org. Chem., 45, 904–912(2009); DOI: 10.1134/S1070428009060189.
Synthesis of 5- and 7-fluoroquinazolin-4(1H)-ones, A. Layeva et al., Russ. Chem. Bull., 56, 1821–1827(2007); DOI: 10.1007/s11172-007-0283-x.
An expedient synthesis of oxazepino and oxazocino quinazolines, A. Hensbergen et al., Tetrahedron Lett., 56(46), 6478–6483(2015); DOI: 10.1016/j.tetlet.2015.10.008.

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