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3,5-Difluorobenzonitrile

CAS Number 64248-63-1

Chemistry Building Blocks, Fluorinated Building Blocks, Monomers


Product Code B2431-10g
Price $82 ex. VAT

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A difluorinated benzonitrile building block

Used as electron acceptors in OLEDs and catalysts in organometallic chemistry


3,5-Difluorobenzonitrile (CAS number 64248-63-1) is a benzonitrile derivatives with two fluorine substituents at the meta-positions. 3,5-Difluorobenzonitrile is applied as an electron acceptor unit in axially chiral excimers/exciplexes showing cyan luminescence. The exciplexes also display thermally activated delayed fluorescence (TADF), which are promising for OLEDs. The chromophore size of 3,5-difluorobenzonitrole can be expended with carbazole derivatives through nucleophilic aromatic substitution. The synthesized 3,5-difluorobenzonitrole-carbazol emitters have photoluminescence quantum yield (PLQY) of 29% and external quantum efficiency (EQE) of 5.3%.

3,5-Difluorobenzonitrile has also found its use in organometallic chemistry. 3,5-Difluorobenzonitrile assists the conversion of catalytically inactive (phosphine)2Ni to (phosphine)Ni(alkene), a desired catalyst intermediate in cross coupling-reactions.

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated building block

Fluorinated benzonitrile building block

For drug discovery, organic synthesis and OLEDs research

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High purity 64248-63-1

High purity

>98% High purity

General Information

CAS Number 64248-63-1
Chemical Formula C7H3F2N
Full Name 3,5-Difluorobenzonitrile
Molecular Weight 139.10 g/mol
Synonyms 5-Cyano-1,3-difluorobenzene
Classification / Family Fluorinated building block, Benzonitrile derivatives, Dyes, OLEDs, Ligands, Catalysts

Chemical Structure

3,5-Difluorobenzonitrile chemical structure, CAS 64248-63-1
3,5-Difluorobenzonitrile chemical structure, CAS 64248-63-1

Product Details

Purity 98%
Melting Point Tm = 84 °C – 86 °C
Appearance White powder

MSDS Documentation

3,5-Difluorobenzonitrile3,5-Difluorobenzonitrile MSDS Sheet

Literature and Reviews

  1. Structural studies of perfluoroaryldiselenadiazolyl radicals: insights into dithiadiazolyl chemistry, R. Melen et al., Inorg. Chem., 55, 11747–1175(2016); DOI: 10.1021/acs.inorgchem.6b01771.
  2. Comprehensive study of the reactions between chelating phosphines and Ni(cod)2, A. Clevenger et al., Organometallics, 37, 19, 3259–3268(2018); DOI: 10.1021/acs.organomet.8b00438.
  3. Luminescent chiral exciplexes with sky-blue and green circularly polarized-thermally activated delayed fluorescence, P. Sumsalee et al., Chem. Eur. J., 27, 16505(2021); DOI: 10.1002/chem.202102765.
  4. An axially chiral thermally activated delayed fluorescent emitter with a dual emitting core for a highly efficient organic light-emitting diode, Y.-F. Wang et al., Chem. Commun., 56, 9380–9383(2020); DOI: 10.1039/D0CC03822A.

To the best of our knowledge the information provided here is accurate. The values provided are typical at the time of manufacture and may vary over time and from batch to batch. Products may have minor cosmetic differences (e.g. to the branding) compared to the photos on our website. All products are for laboratory and research and development use only.

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