FREE shipping to on qualifying orders when you spend or more, processed by Ossila BV. All prices ex. VAT. Qualifying orders ship free worldwide! Fast, secure, and backed by the Ossila guarantee. It looks like you are visiting from , click to shop in or change country. Orders to the EU are processed by our EU subsidiary.

It looks like you are using an unsupported browser. You can still place orders by emailing us on info@ossila.com, but you may experience issues browsing our website. Please consider upgrading to a modern browser for better security and an improved browsing experience.

3-Chloro-2-fluorobenzoic acid

CAS Number 161957-55-7

Chemistry Building Blocks, Fluorinated Building Blocks, Materials, Monomers


Product Code B2741-10g
Price £75 ex. VAT

A dihologenated benzoic acid building block

Serving as a precursor for ligands in applications such as liquid crystals, MOFs, APIs and 19F probe


Specifications | MSDS | Literature and Reviews


3-Chloro-2-fluorobenzoic acid (CAS number 161957-55-7) is derived from benzoic acid, featuring a fluoride and a chloride at 2- and 3-positions. A fluorine probe molecule is prepared from 3-chloro-2-fluorobenzoic acid and hydroxysuccinimide catalysed by N,N’-dicyclohexyl carbodiimide (DCC). The fluorine probe facilitates the identification and quantification of amino acids in metabolomics study using 19F NMR. The carboxylic acid moiety within 3-chloro-2-fluorobenzoic acid can also coordinate to metal centres, enabling the formation of ligands for metal-organic frameworks.

3-Chloro-2-fluorobenzoic acid is also used as a building block for active pharmaceutical ingredients (APIs), notably as Aurora A inhibitors. 3-Chloro-2-fluorobenzoic acid is attached to the molecular scaffold through peptide coupling chemistry with hexafluorophosphate azabenzotriazole tetramethyl uronium (HATU). The resulting products show half-maximal inhibitory concentration upto 3.5 ± 0.29 nM.

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated building block

Fluorinated benzoic acid building block

For drug discovery, liquid crystals, MOFs and biochemistry research

Worldwide shipping for 161957-55-7

Worldwide shipping

Quick and reliable shipping

High purity 161957-55-7

High purity

>98% High purity

General Information


CAS Number 161957-55-7
Chemical Formula C7H4ClFO2
Full Name 3-Chloro-2-fluorobenzoic acid
Molecular Weight 174.56 g/mol
Synonyms 2-Fluoro-3-Chlorobenzoic acid
Classification / Family Fluorinated building blocks, Benzoic acid building blocks, Liquid crystals, Fluorine probes, MOFs, APIs

Chemical Structure


3-Chloro-2-fluorobenzoic acid chemical structure, CAS 161957-55-7.
3-Chloro-2-fluorobenzoic acid chemical structure, CAS 161957-55-7

Product Details


Purity 98%
Melting Point Tm = 177 °C – 180 °C
Appearance White powder

MSDS Documentation


3-Chloro-2-fluorobenzoic acid3-Chloro-2-fluorobenzoic acid MSDS Sheet

Literature and Reviews


  1. Targeted 19F-tags to detect amino acids in complex mixtures using NMR spectroscopy, K. Montgomery et al., J. Fluor. Chem., 26, 110084(2023); DOI: 10.1016/j.jfluchem.2022.110084.
  2. A Eu(III) metal–organic framework based on anthracenyl and alkynyl conjugation as a fluorescence probe for the selective monitoring of Fe3+ and TNP, Y. Zhao et al., RSC Adv., 12, 26945(2022); DOI: 10.1039/d2ra02892a.
  3. Dielectric and electro-optic properties of cybotactic nematic phase in hydrogen-bonded liquid crystals, T. Missaoui et al., J. Mol. Liq., 304, 112726(2020); DOI: 10.1016/j.molliq.2020.112726.
Return to the top