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Product Code B2551-5g
Price $113 ex. VAT

A fluorinated nitrostyrene building block

Used as a Michael acceptor in conjugated addition for chromenes/benzopyran for APIs


Specifications | MSDS | Literature and Reviews


4-Fluoro-β-nitrostyrene (CAS number 706-08-1) is a fluorinated styrene with a nitro group substituted on the β-carbon. 4-Fluoro-β-nitrostyrene is a typical Michael acceptor with the electron withdrawing nitro group, which is readily for conjugated addition. When the conjugated addition is catalysed by a chiral ligand, such as l-proline, syn-addition is favoured, and the chirality of the Michael adducts can be selectively controlled. Hence, 4-fluoro-β-nitrostyrene has been exploited for chiral γ-nitroaldehydes, a precursor for pharmaceutically active γ-aminobutyric acid (GABA). 4-Fluoro-β-nitrostyrene is also used to synthesise benzopyran(chromenes) derivatives as pharmaceutical active ingredients(APIs).

In antibacterial activity study, 4-fluoro-β-nitrostyrene binds to PTP1B enzymes via hydrogen bonding interaction. It is followed by a Michael addition of thiol groups leading to the inhibition of protein tyrosine phosphatases in the microorganisms.

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated building block

Fluorinated nitrostyrene building block

For organic synthesis, medicinal chemistry and biochemistry research

Worldwide shipping for 706-08-01

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High purity 706-08-01

High purity

>98% High purity

General Information


CAS Number 706-08-1
Chemical Formula C8H6FNO2
Full Name 1-Fluoro-4-(2-nitroethenyl)benzene
Molecular Weight 167.14 g/mol
Synonyms 1-(4-Fluorophenyl)-2-nitroethene, 1-Fluoro-4-(2-nitroethenyl)benzene, 1-(4-Fluorophenyl)-2-nitroethylene
Classification / Family Fluorinated building blocks, Michael acceptors, APIs, Heterocycles, Antibiotics

Chemical Structure


4-Fluoro-β-nitrostyrene chemical structure, CAS 706-08-1.
4-Fluoro-β-nitrostyrene chemical structure, CAS 706-08-1

Product Details


Purity 98%
Melting Point Tm = 99 °C – 102 °C
Appearance Cream powder

MSDS Documentation


4-Fluoro-β-nitrostyrene4-Fluoro-β-nitrostyrene MSDS Sheet

Literature and Reviews


  1. Augmentation of enantioselectivity by spatial aminocatalyst: synthesis of 2-alkyl/aryl-3-nitro-2H-chromenes by tandem oxa-Michael-Henry reaction, R. Mohanta et al., J. Org. Chem., 85(7), 4627–4636(2020);DOI: 10.1021/acs.joc.9b03366.
  2. N-Sulfinylpyrrolidine-containing ureas and thioureas as bifunctional organocatalysts, V. Poláčková et al., Beilstein J. Org. Chem., 17, 2629–2641(2021); DOI: 10.3762/bjoc.17.176.
  3. Comparisons of halogenated β-nitrostyrenes as antimicrobial agent, H. Cornell et al., Appl. Sci., 4, 380–389(2014); DOI: 10.3390/app4030380.
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