FREE shipping to on qualifying orders when you spend or more, processed by Ossila BV. All prices ex. VAT. Qualifying orders ship free worldwide! Fast, secure, and backed by the Ossila guarantee. It looks like you are visiting from , click to shop in or change country. Orders to the EU are processed by our EU subsidiary.

It looks like you are using an unsupported browser. You can still place orders by emailing us on info@ossila.com, but you may experience issues browsing our website. Please consider upgrading to a modern browser for better security and an improved browsing experience.


Product Code B2631-25g
Price $113 ex. VAT

Quality assured

Expert support

Volume discounts

Worldwide shipping

Fast and secure


A fluorinated acetophenone building block

Used as a synthesis precursor for chalcone derivatives in application of APIs


3′-Fluoro-4′-methoxyacetophenone (CAS number 455-91-4) is an acetophenone derivative with a fluorine and a methoxy substituents. 3′-Fluoro-4′-methoxyacetophenone is used to prepare chalcone derivatives with benzaldehydes by aldol condensation. Chalcones are α,β-unsaturated ketones employed as active pharmaceutical ingredients (APIs) and fluorescent dyes. Pyrazole derivatives such as celecoxib, an anti-inflammatory drug, are obtained from chalcones reacting with hydrazine derivatives. Chalcone derivatives can be further functionalised to produce epoxides via Juliá–Colonna epoxidation.

3′-Fluoro-4′-methoxyacetophenone is also a key component in Mannich reaction along with formaldehyde and secondary amines, for β-amino-carbonyl compounds, also known as Mannich bases.

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated building block

Fluorinated acetophenone building block

For drug discovery, medicinal chemistry and biochemistry research

Worldwide shipping for 455-91-4

Worldwide shipping

Quick and reliable shipping

High purity 455-91-4

High purity

>98% High purity

General Information

CAS Number 455-91-4
Chemical Formula C9H9FO2
Full Name 1-(3-fluoro-4-methoxyphenyl)ethan-1-one
Molecular Weight 168.17 g/mol
Synonyms 1-(3-Fluoro-4-methoxyphenyl)-1-ethanone
Classification / Family Fluorinated building blocks, Acetophenone building blocks, Heterocycles, APIs

Chemical Structure

3′-Fluoro-4′-methoxyacetophenone chemical structure, CAS 455-91-4.
3′-Fluoro-4′-methoxyacetophenone chemical structure, CAS 455-91-4

Product Details

Purity 98%
Melting Point Tm = 92 °C – 94 °C
Appearance Off-white powder

MSDS Documentation

3′-Fluoro-4′-methoxyacetophenone3′-Fluoro-4′-methoxyacetophenone MSDS Sheet

Literature and Reviews

  1. Automated parallel synthesis of chalcone-based screening libraries, D. Powers et al., Tetrahedron, 54, 4085–4096(1998); DOI: 10.1016/S0040-4020(98)00137-9.
  2. (E)-3-(4-Chlorophenyl)-1-(2-fluoro-4-methoxyphenyl)-2-propen-1-one, N. Bailey et al., Molbank, 2021, M1184(2021); DOI: 10.3390/M1184.
  3. Synthesis of 1-aryl-3-phenethylamino-1-propanone hydrochlorides as possible potent cytotoxic agents, E. Mete et al., Molecules, 12(12); 2579–2588(2007); DOI: 10.3390/12122579.
  4. Practical synthesis of chalcone derivatives and their biological activities, J.-C. Jung et al., Molecules, 22, 1872(2017); DOI: 10.3390/molecules22111872.
  5. Synthesis and cyclooxygenase-2 inhibiting property of 1,5-diacrylpyrazoles with substituted benzenesulfonamide moiety as pharmacophore: preparation of sodium salt for injectable formulation, M. Pal et al., J. Med. Chem., 46, 3975–3984(2003); DOI: 10.1021/jm020563g.

To the best of our knowledge the information provided here is accurate. The values provided are typical at the time of manufacture and may vary over time and from batch to batch. Products may have minor cosmetic differences (e.g. to the branding) compared to the photos on our website. All products are for laboratory and research and development use only.

Return to the top