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3′-Fluoro-4′-methoxyacetophenone CAS 455-91-4
Product Code B2631-25g
Price £90 ex. VAT
£ GBP

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A fluorinated acetophenone building block

Used as a synthesis precursor for chalcone derivatives in application of APIs

3′-Fluoro-4′-methoxyacetophenone (CAS number 455-91-4) is an acetophenone derivative with a fluorine and a methoxy substituents. 3′-Fluoro-4′-methoxyacetophenone is used to prepare chalcone derivatives with benzaldehydes by aldol condensation. Chalcones are α,β-unsaturated ketones employed as active pharmaceutical ingredients (APIs) and fluorescent dyes. Pyrazole derivatives such as celecoxib, an anti-inflammatory drug, are obtained from chalcones reacting with hydrazine derivatives. Chalcone derivatives can be further functionalised to produce epoxides via Juliá–Colonna epoxidation.

3′-Fluoro-4′-methoxyacetophenone is also a key component in Mannich reaction along with formaldehyde and secondary amines, for β-amino-carbonyl compounds, also known as Mannich bases.

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated building block

Fluorinated acetophenone building block

For drug discovery, medicinal chemistry and biochemistry research

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High purity 455-91-4

High purity

>98% High purity

General Information

CAS Number 455-91-4
Chemical Formula C9H9FO2
Full Name 1-(3-fluoro-4-methoxyphenyl)ethan-1-one
Molecular Weight 168.17 g/mol
Synonyms 1-(3-Fluoro-4-methoxyphenyl)-1-ethanone
Classification / Family Fluorinated building blocks, Acetophenone building blocks, Heterocycles, APIs

Chemical Structure

3′-Fluoro-4′-methoxyacetophenone chemical structure, CAS 455-91-4.
3′-Fluoro-4′-methoxyacetophenone chemical structure, CAS 455-91-4

Product Details

Purity 98%
Melting Point Tm = 92 °C – 94 °C
Appearance Off-white powder

MSDS Documentation

3′-Fluoro-4′-methoxyacetophenone3′-Fluoro-4′-methoxyacetophenone MSDS Sheet

Literature and Reviews

  1. Automated parallel synthesis of chalcone-based screening libraries, D. Powers et al., Tetrahedron, 54, 4085–4096(1998); DOI: 10.1016/S0040-4020(98)00137-9.
  2. (E)-3-(4-Chlorophenyl)-1-(2-fluoro-4-methoxyphenyl)-2-propen-1-one, N. Bailey et al., Molbank, 2021, M1184(2021); DOI: 10.3390/M1184.
  3. Synthesis of 1-aryl-3-phenethylamino-1-propanone hydrochlorides as possible potent cytotoxic agents, E. Mete et al., Molecules, 12(12); 2579–2588(2007); DOI: 10.3390/12122579.
  4. Practical synthesis of chalcone derivatives and their biological activities, J.-C. Jung et al., Molecules, 22, 1872(2017); DOI: 10.3390/molecules22111872.
  5. Synthesis and cyclooxygenase-2 inhibiting property of 1,5-diacrylpyrazoles with substituted benzenesulfonamide moiety as pharmacophore: preparation of sodium salt for injectable formulation, M. Pal et al., J. Med. Chem., 46, 3975–3984(2003); DOI: 10.1021/jm020563g.
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