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Product Code B2341-1g
Price £80 ex. VAT

A fluorinated S-chiral pyrrolidine

A synthesis building block or ligand for APIs and ferroelectrics.

Specifications | MSDS | Literature and Reviews

(S)-(+)-3-Fluoropyrrolidine hydrochloride (CAS number 136725-53-6) is a pyrrolidinium chloride salt with a fluorine substituent on the S-chiral carbon (3-position). The secondary amine in (S)-(+)-3-fluoropyrrolidine hydrochloride enables it to be used as a ligand for metal complexes. A cadmium-(S)-(+)-3-fluoropyrrolidine perovskite ferroelectric has Curie temperature (Tc) at 303 K, which is 63 K higher than those of non-substituted cadmium-pyrrolidine complexes. (S)-(+)-3-Fluoropyrrolidine hydrochloride extends the working temperature of ferroelectrics to room temperature.

(S)-(+)-3-Fluoropyrrolidine hydrochloride can be easily attached to molecular scaffolds through nucleophilic substitution. It is, therefore, used in preparing analogues of active pharmaceutical ingredients (APIs). An (S)-(+)-3-fluoropyrrolidine hydrochloride modified pyrazolopyridazine inhibitor of tyrosine regulated kinase showed pIC50 (negative log of half maximal inhibitory concentration) of 6.73.

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated building block

Fluorinated S-pyrrolidine building block

For drug discovery, ferroelectrics and organic synthesis

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High purity 136725-53-6

High purity

>97% High purity

General Information

CAS Number 136725-53-6
Chemical Formula C4H9ClFN
Full Name (S)-(+)-3-Fluoropyrrolidine hydrochloride
Molecular Weight 125.57 g/mol
Synonyms (S)-(+)-3-Fluoropyrrolidine HCl, (3S)-3-Fluoropyrrolidine hydrochloride, (S)-3-Fluoropyrrolidine hydrochloride
Classification / Family Fluorinated building block, Heterocyclic building block, Chiral building block, APIs, Ligands, Ferroelectrics

Chemical Structure

(S)-(+)-3-Fluoropyrrolidine hydrochloride chemical structure, CAS 136725-53-6
(S)-(+)-3-Fluoropyrrolidine hydrochloride chemical structure, CAS 136725-53-6

Product Details

Purity 97%
Melting Point Tm = 183 187 °C
Optical Rotation 8.88 ° (c = 1, methanol)
Appearance Pink/beige powder

MSDS Documentation

(S)-(+)-3-Fluoropyrrolidine hydrochloride(S)-(+)-3-Fluoropyrrolidine hydrochloride MSDS Sheet

Literature and Reviews

  1. Discovery and characterization of selective and ligand-efficient DYRK inhibitors, S. Henderson et al., J. Med. Chem., 64, 11709−11728(2021); DOI: 10.1021/acs.jmedchem.1c01115.
  2. Discovery of MK-8719, a potent o-GlcNAcase inhibitor as a potential treatment for tauopathies, H. Selnick et al., J. Med. Chem., 62, 10062−10097(2019); DOI: 10.1021/acs.jmedchem.9b01090.
  3. H/F-substitution-induced homochirality for designing high-Tc molecular perovskite ferroelectrics, Y.-Y. Tang et al., Adv. Mater., 31(29), 1902163(2019); DOI: 10.1002/adma.201902163.
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