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(S)-(+)-3-Fluoropyrrolidine hydrochloride

CAS Number 136725-53-6

Chemistry Building Blocks, Fluorinated Building Blocks, Heterocyclic Building Blocks, Monomers


Product Code B2341-1g
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A fluorinated S-chiral pyrrolidine

A synthesis building block or ligand for APIs and ferroelectrics.


(S)-(+)-3-Fluoropyrrolidine hydrochloride (CAS number 136725-53-6) is a pyrrolidinium chloride salt with a fluorine substituent on the S-chiral carbon (3-position). The secondary amine in (S)-(+)-3-fluoropyrrolidine hydrochloride enables it to be used as a ligand for metal complexes. A cadmium-(S)-(+)-3-fluoropyrrolidine perovskite ferroelectric has Curie temperature (Tc) at 303 K, which is 63 K higher than those of non-substituted cadmium-pyrrolidine complexes. (S)-(+)-3-Fluoropyrrolidine hydrochloride extends the working temperature of ferroelectrics to room temperature.

(S)-(+)-3-Fluoropyrrolidine hydrochloride can be easily attached to molecular scaffolds through nucleophilic substitution. It is, therefore, used in preparing analogues of active pharmaceutical ingredients (APIs). An (S)-(+)-3-fluoropyrrolidine hydrochloride modified pyrazolopyridazine inhibitor of tyrosine regulated kinase showed pIC50 (negative log of half maximal inhibitory concentration) of 6.73.

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated building block

Fluorinated S-pyrrolidine building block

For drug discovery, ferroelectrics and organic synthesis

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High purity 136725-53-6

High purity

>97% High purity

General Information

CAS Number 136725-53-6
Chemical Formula C4H9ClFN
Full Name (S)-(+)-3-Fluoropyrrolidine hydrochloride
Molecular Weight 125.57 g/mol
Synonyms (S)-(+)-3-Fluoropyrrolidine HCl, (3S)-3-Fluoropyrrolidine hydrochloride, (S)-3-Fluoropyrrolidine hydrochloride
Classification / Family Fluorinated building block, Heterocyclic building block, Chiral building block, APIs, Ligands, Ferroelectrics

Chemical Structure

(S)-(+)-3-Fluoropyrrolidine hydrochloride chemical structure, CAS 136725-53-6
(S)-(+)-3-Fluoropyrrolidine hydrochloride chemical structure, CAS 136725-53-6

Product Details

Purity 97%
Melting Point Tm = 183 187 °C
Optical Rotation 8.88 ° (c = 1, methanol)
Appearance Pink/beige powder

MSDS Documentation

(S)-(+)-3-Fluoropyrrolidine hydrochloride(S)-(+)-3-Fluoropyrrolidine hydrochloride MSDS Sheet

Literature and Reviews

  1. Discovery and characterization of selective and ligand-efficient DYRK inhibitors, S. Henderson et al., J. Med. Chem., 64, 11709−11728(2021); DOI: 10.1021/acs.jmedchem.1c01115.
  2. Discovery of MK-8719, a potent o-GlcNAcase inhibitor as a potential treatment for tauopathies, H. Selnick et al., J. Med. Chem., 62, 10062−10097(2019); DOI: 10.1021/acs.jmedchem.9b01090.
  3. H/F-substitution-induced homochirality for designing high-Tc molecular perovskite ferroelectrics, Y.-Y. Tang et al., Adv. Mater., 31(29), 1902163(2019); DOI: 10.1002/adma.201902163.
  4. Ultrapotent vinblastines in which added molecular complexity further disrupts the target tubulin dimer–dimer interface, D. Carney et al., PNAS, 113(35), 9691−9698(2016); DOI: 10.1073/pnas.1611405113.
  5. Urea derivatives of 2-aryl-benzothiazol-5-amines: a new class of potential drugs for human African trypanosomiasis, J. Med. Chem., 60(3), 957−971(2017); DOI: 10.1021/acs.jmedchem.6b01163.

To the best of our knowledge the information provided here is accurate. The values provided are typical at the time of manufacture and may vary over time and from batch to batch. Products may have minor cosmetic differences (e.g. to the branding) compared to the photos on our website. All products are for laboratory and research and development use only.

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