FREE shipping to on qualifying orders when you spend or more, processed by Ossila BV. All prices ex. VAT. Qualifying orders ship free worldwide! Fast, secure, and backed by the Ossila guarantee. It looks like you are visiting from , click to shop in or change country. Orders to the EU are processed by our EU subsidiary.

It looks like you are using an unsupported browser. You can still place orders by emailing us on info@ossila.com, but you may experience issues browsing our website. Please consider upgrading to a modern browser for better security and an improved browsing experience.


Product Code B2341-1g
Price £80 ex. VAT

A fluorinated S-chiral pyrrolidine

A synthesis building block or ligand for APIs and ferroelectrics.


Specifications | MSDS | Literature and Reviews


(S)-(+)-3-Fluoropyrrolidine hydrochloride (CAS number 136725-53-6) is a pyrrolidinium chloride salt with a fluorine substituent on the S-chiral carbon (3-position). The secondary amine in (S)-(+)-3-fluoropyrrolidine hydrochloride enables it to be used as a ligand for metal complexes. A cadmium-(S)-(+)-3-fluoropyrrolidine perovskite ferroelectric has Curie temperature (Tc) at 303 K, which is 63 K higher than those of non-substituted cadmium-pyrrolidine complexes. (S)-(+)-3-Fluoropyrrolidine hydrochloride extends the working temperature of ferroelectrics to room temperature.

(S)-(+)-3-Fluoropyrrolidine hydrochloride can be easily attached to molecular scaffolds through nucleophilic substitution. It is, therefore, used in preparing analogues of active pharmaceutical ingredients (APIs). An (S)-(+)-3-fluoropyrrolidine hydrochloride modified pyrazolopyridazine inhibitor of tyrosine regulated kinase showed pIC50 (negative log of half maximal inhibitory concentration) of 6.73.

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated building block

Fluorinated S-pyrrolidine building block

For drug discovery, ferroelectrics and organic synthesis

Worldwide shipping for 136725-53-6

Worldwide shipping

Quick and reliable shipping

High purity 136725-53-6

High purity

>97% High purity

General Information


CAS Number 136725-53-6
Chemical Formula C4H9ClFN
Full Name (S)-(+)-3-Fluoropyrrolidine hydrochloride
Molecular Weight 125.57 g/mol
Synonyms (S)-(+)-3-Fluoropyrrolidine HCl, (3S)-3-Fluoropyrrolidine hydrochloride, (S)-3-Fluoropyrrolidine hydrochloride
Classification / Family Fluorinated building block, Heterocyclic building block, Chiral building block, APIs, Ligands, Ferroelectrics

Chemical Structure


(S)-(+)-3-Fluoropyrrolidine hydrochloride chemical structure, CAS 136725-53-6
(S)-(+)-3-Fluoropyrrolidine hydrochloride chemical structure, CAS 136725-53-6

Product Details


Purity 97%
Melting Point Tm = 183 187 °C
Optical Rotation 8.88 ° (c = 1, methanol)
Appearance Pink/beige powder

MSDS Documentation


(S)-(+)-3-Fluoropyrrolidine hydrochloride(S)-(+)-3-Fluoropyrrolidine hydrochloride MSDS Sheet

Literature and Reviews


  1. Discovery and characterization of selective and ligand-efficient DYRK inhibitors, S. Henderson et al., J. Med. Chem., 64, 11709−11728(2021); DOI: 10.1021/acs.jmedchem.1c01115.
  2. Discovery of MK-8719, a potent o-GlcNAcase inhibitor as a potential treatment for tauopathies, H. Selnick et al., J. Med. Chem., 62, 10062−10097(2019); DOI: 10.1021/acs.jmedchem.9b01090.
  3. H/F-substitution-induced homochirality for designing high-Tc molecular perovskite ferroelectrics, Y.-Y. Tang et al., Adv. Mater., 31(29), 1902163(2019); DOI: 10.1002/adma.201902163.
Return to the top