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3-Bromo-5-fluorophenol

CAS Number 433939-27-6

Chemistry Building Blocks, Fluorinated Building Blocks, Monomers


Product Code B3231-5g
Price $42 ex. VAT

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A fluorinated phenol building block

As a tri-functionalised molecular scaffold for the synthesis of APIs


3-Bromo-5-fluorophenol (CAS number: 433939-27-6), is a phenol derivative that contains both bromide and fluoride functional groups. The three functional groups of 3-bromo-5-fluorophenol exhibit distinct reactivity. The hydroxy group is capable of undergoing nucleophilic substitution and Mitsunobu reactions, while the bromo-group is well-suited for metal-catalysed cross-coupling reactions. The fluoride substituent reacts with nucleophiles via nucleophilic aromatic substitution, or it can be preserved to enhance the binding affinity of synthesized active pharmaceutical ingredients (APIs).

3-Bromo-5-fluorophenol is commonly utilised as a molecular scaffold for APIs. Anticancer 3,4'-substituted diaryl guanidinium derivatives are synthesised from 3-bromo-5-fluorophenol, demonstrating an inhibition of 4.07 ± 0.10 µM against the human promyelocytic leukaemia (HL-60) cell line.

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated phenol building block

Fluorinated phenol building block

For drug discovery, medicinal chemistry, and organic synthesis

competitively priced 433939-27-6

Low Cost

Competitively priced, high quality product

High purity 433939-27-6

High purity

>98% High purity

General Information

CAS Number 433939-27-6
Chemical Formula C6H4BrFO
Full Name 3-Bromo-5-fluorophenol
Molecular Weight 191.00 g/mol
Synonyms 3-Fluoro-5-Bromophenol
Classification / Family Fluorinated building block, Halogenated building blocks, Phenol building blocks, APIs

Chemical Structure

https://cdn.shopify.com/s/files/1/0823/0287/files/3-bromo-5-fluorophenol-chemical-structure-body.png
3-Bromo-5-fluorophenol chemical structure, CAS 433939-27-6

Product Details

Purity 98%
Melting Point Tm = 36 °C – 40 °C
Appearance White Powder

MSDS Documentation

3-Bromo-5-fluorophenol3-Bromo-5-fluorophenol MSDS Sheet

Literature and Reviews

  1. Mosquito acetylcholinesterase as a target for novel phenyl-substituted carbamates, J. Mutunga et al., Int. J. Environ. Res. Public Health, 16, 1500 (2019); DOI: 10.3390/ijerph16091500.
  2. The twin drug approach for novel nicotinic acetylcholine receptor ligands, Bioorg. Med. Chem., 23 (15), 4375–4389 (2015); DOI: 10.1016/j.bmc.2015.06.034.
  3. Exploring the anti-cancer mechanism of novel 3,4'-substituted diaryl guanidinium derivatives, V. Previtali et al., Pharmaceuticals, 13, 485 (2020); DOI: 10.3390/ph13120485.
  4. Non-acidic free fatty acid receptor 4 agonists with antidiabetic activity, C. Azevedo et al., J. Med. Chem., 59 (19), 8868–8878 (2016); DOI: 10.1021/acs.jmedchem.6b00685.

To the best of our knowledge the information provided here is accurate. The values provided are typical at the time of manufacture and may vary over time and from batch to batch. Products may have minor cosmetic differences (e.g. to the branding) compared to the photos on our website. All products are for laboratory and research and development use only.

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