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Product Code B3231-5g
Price £33 ex. VAT

A fluorinated phenol building block

As a tri-functionalised molecular scaffold for the synthesis of APIs

Specifications | MSDS | Literature and Reviews

3-Bromo-5-fluorophenol (CAS number: 433939-27-6), is a phenol derivative that contains both bromide and fluoride functional groups. The three functional groups of 3-bromo-5-fluorophenol exhibit distinct reactivity. The hydroxy group is capable of undergoing nucleophilic substitution and Mitsunobu reactions, while the bromo-group is well-suited for metal-catalysed cross-coupling reactions. The fluoride substituent reacts with nucleophiles via nucleophilic aromatic substitution, or it can be preserved to enhance the binding affinity of synthesized active pharmaceutical ingredients (APIs).

3-Bromo-5-fluorophenol is commonly utilised as a molecular scaffold for APIs. Anticancer 3,4'-substituted diaryl guanidinium derivatives are synthesised from 3-bromo-5-fluorophenol, demonstrating an inhibition of 4.07 ± 0.10 µM against the human promyelocytic leukaemia (HL-60) cell line.

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated phenol building block

Fluorinated phenol building block

For drug discovery, medicinal chemistry, and organic synthesis

competitively priced 433939-27-6

Low Cost

Competitively priced, high quality product

High purity 433939-27-6

High purity

>98% High purity

General Information

CAS Number 433939-27-6
Chemical Formula C6H4BrFO
Full Name 3-Bromo-5-fluorophenol
Molecular Weight 191.00 g/mol
Synonyms 3-Fluoro-5-Bromophenol
Classification / Family Fluorinated building block, Halogenated building blocks, Phenol building blocks, APIs

Chemical Structure
3-Bromo-5-fluorophenol chemical structure, CAS 433939-27-6

Product Details

Purity 98%
Melting Point Tm = 36 °C – 40 °C
Appearance White Powder

MSDS Documentation

3-Bromo-5-fluorophenol3-Bromo-5-fluorophenol MSDS Sheet

Literature and Reviews

  1. Mosquito acetylcholinesterase as a target for novel phenyl-substituted carbamates, J. Mutunga et al., Int. J. Environ. Res. Public Health, 16, 1500 (2019); DOI: 10.3390/ijerph16091500.
  2. The twin drug approach for novel nicotinic acetylcholine receptor ligands, Bioorg. Med. Chem., 23 (15), 4375–4389 (2015); DOI: 10.1016/j.bmc.2015.06.034.
  3. Exploring the anti-cancer mechanism of novel 3,4'-substituted diaryl guanidinium derivatives, V. Previtali et al., Pharmaceuticals, 13, 485 (2020); DOI: 10.3390/ph13120485.

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