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1-Bromo-2-chloro-4-fluorobenzene

CAS Number 110407-59-5

Chemistry Building Blocks, Fluorinated Building Blocks, Monomers

1-Bromo-2-chloro-4-fluorobenzene CAS 110407-59-5
Product Code B2841-10g
Price £70 ex. VAT
£ GBP

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A polyhalogenated benzene building block

Used as an intermediate for APIs synthesis in treatment of breast cancer and catalysts in peptide synthesis.

1-Bromo-2-chloro-4-fluorobenzene (CAS number 110407-59-5) is derived from benzene, bearing bromide, chloride and fluoride substituents. 1-Bromo-2-chloro-4-fluorobenzene serves as a crucial building block for synthesising brilanestrant, a selective estrogen receptor degrader used in the treatment of breast cancer. 1-Bromo-2-chloro-4-fluorobenzene controls the potency on the degradation of estrogen receptor 1 (ERα), demonstrating an effective concentration of 0.7 nM.

1-Bromo-2-chloro-4-fluorobenzene is also used in the preparation of a biphenyl catalyst for peptide synthesis. The preparation of the catalyst begins with the synthesis of the Grignard reagent of 1-bromo-2-chloro-4-fluorobenzene yielding a magnesium bromide analogue. The resulting product subsequently reacts with trimethyl borate, followed by an acid hydration. The boronic acid product shows high catalytic efficiency of peptide synthesis, achieving a 97% conversion over a 4-hour reaction.

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated building block

Fluorinated benzene building block

for drug discovery, medicinal chemistry and biochemistry research

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High purity 110407-59-5

High purity

>98% High purity

General Information

CAS Number 110407-59-5
Chemical Formula C6H3BrClF
Full Name 1-Bromo-2-chloro-4-fluorobenzene
Molecular Weight 209.44 g/mol
Synonyms 2-Chloro-4-fluorobromobenzene
Classification / Family Fluorinated building blocks, Brominated building blocks, Chlorinated building blocks, APIs, Catalysts

Chemical Structure

1-Bromo-2-chloro-4-fluorobenzene chemical structure, CAS 110407-59-5.
1-Bromo-2-chloro-4-fluorobenzene chemical structure, CAS 110407-59-5

Product Details

Purity 98%
Boiling Point Tb = 193 °C – 195 °C at 760 mmHg
Relative Density 1.75 g/mL
Appearance Clear liquid

MSDS Documentation

1-Bromo-2-chloro-4-fluorobenzene1-Bromo-2-chloro-4-fluorobenzene MSDS Sheet

Literature and Reviews

  1. Fluoronaphthalene building blocks via arynes: a solution to the problem of positional selectivity, E. Masson et al., Eur. J. Org. Chem., 2005(20), 4401–4405(2005); DOI: 10.1002/ejoc.200500390.
  2. Synthesis of mono- and dimethoxylated polychlorinated biphenyls derivatives starting from fluoroarene derivatives, R. Dhakal et al., Environ. Sci. Pollut. Res. Int., 27(9), 8905–8925(2020). DOI: 10.1007/s11356-019-07133-3.
  3. Borinic acid catalysed peptide synthesis, T. El Dine et al., Chem. Commun., 51, 16084–16087(2015); DOI: 10.1039/c5cc06177f.
  4. Targeting the estrogen receptor for the treatment of breast cancer: recent advances and challenges, R. Rej et al., J. Med. Chem., 66(13), 8339–8381(2023); DOI: 10.1021/acs.jmedchem.3c00136.
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