FREE shipping to on qualifying orders when you spend or more, processed by Ossila BV. All prices ex. VAT. Qualifying orders ship free worldwide! Fast, secure, and backed by the Ossila guarantee. It looks like you are visiting from , click to shop in or change country. Orders to the EU are processed by our EU subsidiary.

It looks like you are using an unsupported browser. You can still place orders by emailing us on info@ossila.com, but you may experience issues browsing our website. Please consider upgrading to a modern browser for better security and an improved browsing experience.


Product Code B2721-10g
Price $125 ex. VAT

Quality assured

Expert support

Volume discounts

Worldwide shipping

Fast and secure


A fluorinated benzoic hydrazide building block

Used as a synthesis intermediate for heterocyclic compounds


3-Fluorobenzoic hydrazide (CAS number 499-55-8) is a hydrazide building block, derived from benzoic acid. Hydrazide derivatives are bioactive, for example isoniazid which is an antibiotic for tuberculosis. The hydrazide moiety in 3-fluorobenzoic hydrazide is nucleophilic and readily reacts with electrophiles, such as isothiocyanate derivatives. The resulting hydrazide-isothiocyanate products can undergo further cyclisation, forming triazole-thione derivatives. The triazole-thione derivatives synthesised in this manner show antimicrobial activity, with a minimum inhibitory concentration (MIC) of 62.5 µg/mL. Additionally, they have low toxicity against human cells. The heterocycles synthesised from 3-fluorobenzoic hydrazide allow for late-stage functionalisation, owing to their multiple functionalities.

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated building block

Fluorinated hydrazide building block

For drug discovery, medicinal chemistry and biochemistry research

Worldwide shipping for 499-55-8

Worldwide shipping

Quick and reliable shipping

High purity 499-55-8

High purity

>97% High purity

General Information

CAS Number 499-55-8
Chemical Formula C7H7FN2O
Full Name 3-Fluorobenzoic hydrazide
Molecular Weight 154.14 g/mol
Synonyms 3-Fluorobenzohydrazide, 3-Fluorobenzoic acid hydrazide, 3-Fluorobenzhydrazide
Classification / Family Fluorinated building blocks, Hydrazide building blocks, Heterocycles, APIs

Chemical Structure

3-Fluorobenzoic hydrazide chemical structure, CAS 499-55-8.
3-Fluorobenzoic hydrazide chemical structure, CAS 499-55-8

Product Details

Purity 97%
Melting Point Tm = 139 °C – 143 °C
Appearance Off white to beige fibres

MSDS Documentation

3-Fluorobenzoic hydrazide3-Fluorobenzoic hydrazide MSDS Sheet

Literature and Reviews

  1. Cyclization of 3-ethoxycarbonyliminocoumarin into benzopyrano[2,3-c]pyrazoles, N, Abid-Jarraya et al., J. Soc. Chim. Tunisie, 16, 75–81(2014); DOI:NA.
  2. Synthesis, characterization and antimicrobial evaluation of some new Schiff, Mannich and acetylenic Mannich bases incorporating a 1,2,4-trazole nucleus, M. Aouad, Molecules, 19, 18897–18910(2014); DOI: 10.3390/molecules191118897.
  3. Synthesis and biological evaluation of new Schiff bases derived from 4-amino-5-(3-fluorophenyl)-1,2,4-triazole-3-thione, S. Janowska et al., Molecules, 28, 2718(2023). DOI: 10.3390/molecules28062718.
  4. Synthesis and antimicrobial activity of new Mannich bases with piperazine moiety, S. Janowska et al., Molecules, 28, 5562(2023); DOI: 10.3390/molecules28145562.

To the best of our knowledge the information provided here is accurate. The values provided are typical at the time of manufacture and may vary over time and from batch to batch. Products may have minor cosmetic differences (e.g. to the branding) compared to the photos on our website. All products are for laboratory and research and development use only.

Return to the top