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Product Code B2721-10g
Price £100 ex. VAT

A fluorinated benzoic hydrazide building block

Used as a synthesis intermediate for heterocyclic compounds

Specifications | MSDS | Literature and Reviews

3-Fluorobenzoic hydrazide (CAS number 499-55-8) is a hydrazide building block, derived from benzoic acid. Hydrazide derivatives are bioactive, for example isoniazid which is an antibiotic for tuberculosis. The hydrazide moiety in 3-fluorobenzoic hydrazide is nucleophilic and readily reacts with electrophiles, such as isothiocyanate derivatives. The resulting hydrazide-isothiocyanate products can undergo further cyclisation, forming triazole-thione derivatives. The triazole-thione derivatives synthesised in this manner show antimicrobial activity, with a minimum inhibitory concentration (MIC) of 62.5 µg/mL. Additionally, they have low toxicity against human cells. The heterocycles synthesised from 3-fluorobenzoic hydrazide allow for late-stage functionalisation, owing to their multiple functionalities.

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated building block

Fluorinated hydrazide building block

For drug discovery, medicinal chemistry and biochemistry research

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High purity 499-55-8

High purity

>97% High purity

General Information

CAS Number 499-55-8
Chemical Formula C7H7FN2O
Full Name 3-Fluorobenzoic hydrazide
Molecular Weight 154.14 g/mol
Synonyms 3-Fluorobenzohydrazide, 3-Fluorobenzoic acid hydrazide, 3-Fluorobenzhydrazide
Classification / Family Fluorinated building blocks, Hydrazide building blocks, Heterocycles, APIs

Chemical Structure

3-Fluorobenzoic hydrazide chemical structure, CAS 499-55-8.
3-Fluorobenzoic hydrazide chemical structure, CAS 499-55-8

Product Details

Purity 97%
Melting Point Tm = 139 °C – 143 °C
Appearance Off white to beige fibres

MSDS Documentation

3-Fluorobenzoic hydrazide3-Fluorobenzoic hydrazide MSDS Sheet

Literature and Reviews

  1. Cyclization of 3-ethoxycarbonyliminocoumarin into benzopyrano[2,3-c]pyrazoles, N, Abid-Jarraya et al., J. Soc. Chim. Tunisie, 16, 75–81(2014); DOI:NA.
  2. Synthesis, characterization and antimicrobial evaluation of some new Schiff, Mannich and acetylenic Mannich bases incorporating a 1,2,4-trazole nucleus, M. Aouad, Molecules, 19, 18897–18910(2014); DOI: 10.3390/molecules191118897.
  3. Synthesis and biological evaluation of new Schiff bases derived from 4-amino-5-(3-fluorophenyl)-1,2,4-triazole-3-thione, S. Janowska et al., Molecules, 28, 2718(2023). DOI: 10.3390/molecules28062718.
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