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4-Fluoro-3-nitrobenzoic acid

CAS Number 453-71-4

Chemistry Building Blocks, Fluorinated Building Blocks, Materials, Monomers


Product Code B2271-25g
Price $90 ex. VAT

A fluorinated building block with multiple functional groups

A versatile building block to synthesize benzimidazoles, benzoselenazoles and polymersomes for APIs and fluorescent dyes


Specifications | MSDS | Literature and Reviews


4-Fluoro-3-nitrobenzoic acid (CAS number 453-71-4) is derived from benzoic acid having a nitro and a fluoro substituents at 3- and 4-positions. The functional groups in 4-fluoro-3-nitrobenzoic acid possess different reactivities. The carboxylic acid reacts with alcohols for esters. Fluoride substituent favours nucleophilic aromatic substitution while nitro group can be reduced to an amine as a nucleophile. The ortho-position of fluoride and nitro makes 4-fluoro-3-nitrobenzoic acid an ideal precursor for making benzimidazoles derivatives. Benzimidazoles are active pharmaceutical ingredients applied as antimicrobials, opioids, antipsychotics and antihistamines. Benzoselenazoles (similar to benzimidazole, one nitrogen is replaced by a selenium atom) can be synthesized from 4-fluoro-3-nitrobenzoic acid reacting with isoselenocyanate.

It is feasible to attach various polymers to 4-fluoro-3-nitrobenzoic acid for block-co-polymers, in order to construct polymersomes.

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated building block

Fluorinated benzoic acid building block

For drug discovery, fluorescent dyes, and organic synthesis

Worldwide shipping for 453-71-4

Worldwide shipping

Quick and reliable shipping

High purity 453-71-4

High purity

>98% High purity

General Information


CAS Number 453-71-4
Chemical Formula C7H4FNO4
Full Name 4-Fluoro-3-nitrobenzoic acid
Molecular Weight 185.11 g/mol
Synonyms N/A
Classification / Family Fluorinated building block, APIs, Fluorescent dyes

Chemical Structure


4-Fluoro-3-nitrobenzoic acid chemical structure, CAS 453-71-4
4-Fluoro-3-nitrobenzoic acid chemical structure, CAS 453-71-4

Product Details


Purity 98%
Melting Point Tm = 123 – 126 °C
Appearance White to off-white powder

MSDS Documentation


4-Fluoro-3-nitrobenzoic acid4-Fluoro-3-nitrobenzoic acid MSDS Sheet

Literature and Reviews


  1. Antituberculosis: synthesis and antimycobacterial activity of novel benzimidazole derivatives, Y. Yoon et al., Biomed Res. Int., 2013, 926309(2013); DOI: 10.1155/2013/926309.
  2. Discovery of a potent and highly fluorescent sirtuin inhibitor, Y. Yoon et al., Med. Chem. Commun., 6, 1857–1863(2015); DOI: 10.1039/C5MD00307E.
  3. Leuko-polymersomes, D. Hammer et al., Faraday Discuss., 139, 129-141(2008); DOI: 10.1039/B717821B.

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