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Product Code B3261-500mg
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A fluorinated pyridine building block

Used as a synthesis intermediate for APIs and synthetic ligands

3-Fluoro-4-iodopyridine (CAS number 22282-75-3) is a pyridine derivative with a fluoride and an iodide at 3- and 4-positions, respectively. This dihalogenated heterocyclic building block is commonly used as a molecular scaffold for active pharmaceutical ingredients (APIs) and a substrate for synthetic chemistry. The synthesis of an antibiotic Eudistomin T involves the Suzuki coupling reaction of 3-fluoro-4-iodopyridine with (2-pivaloylaminophenyl)boronic acid, followed by lithiation to yield the trisubstituted pyridine. A cyclization reaction is then carried out to complete the formation of Eudistomin T.

3-Fluoro-4-iodopyridine is one of the key building blocks for the synthesis of β-carboline. β-Carboline finds extensive applications in anti-cancer treatments, neuroenhancement and neuroprotection.

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated pyridine building block

Fluorinated pyridine building block

For drug discovery, medicinal chemistry, and organic synthesis

competitively priced 22282-75-3

Low Cost

Competitively priced, high quality product

High purity 22282-75-3

High purity

>97% High purity

General Information

CAS Number 22282-75-3
Chemical Formula C5H3FIN
Full Name 3-Fluoro-4-iodopyridine
Molecular Weight 222.99 g/mol
Synonyms 4-Iodo-3-fluoropyridine
Classification / Family Fluorinated building blocks, Heterocyclic building blocks, Pyridine building blocks, APIs, Organic synthesis

Chemical Structure

3-Fluoro-4-iodopyridine chemical structure, CAS 22282-75-3
3-Fluoro-4-iodopyridine chemical structure, CAS 22282-75-3

Product Details

Purity 97%
Melting Point Tm = 85 °C – 89 °C
Appearance Off-White Powder/Fibres

MSDS Documentation

3-Fluoro-4-iodopyridine3-Fluoro-4-iodopyridine MSDS Sheet

Literature and Reviews

  1. Carbolines, part VIII. An original synthesis of the antibiotic Eudistomin T, P. Rocca et al., Synth. Commun., 25 (32), 3373–3379 (1995); DOI: 10.1080/00397919508013858.
  2. Continuous-flow divergent lithiation of 2,3-dihalopyridines: deprotolithiation versus halogen dance, T. Brégent et al., Chem. Eur. J., 28, e202202286 (2022); DOI: 10.1002/chem.202202286.
  3. Engineering hydrogen bonding to align molecular dipoles in organic solids for efficient second harmonic generation, R. Zhao et al., Chem. Sci., 13, 12144 (2022); DOI: 10.1039/d2sc03994j.
  4. Enantio- and Z-selective synthesis of functionalized alkenes bearing tertiary allylic stereogenic center, L. Ge et al., Sci. Adv., 9, eadf8742 (2023); DOI: 10.1126/sciadv.adf8742.

To the best of our knowledge the information provided here is accurate. The values provided are typical at the time of manufacture and may vary over time and from batch to batch. Products may have minor cosmetic differences (e.g. to the branding) compared to the photos on our website. All products are for laboratory and research and development use only.

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