3-Fluoro-4-iodopyridine

CAS Number 22282-75-3

Chemistry Building Blocks, Fluorinated Building Blocks, Heterocyclic Building Blocks, Monomers

A fluorinated pyridine building block

Used as a synthesis intermediate for APIs and synthetic ligands

Overview
Related Products

3-Fluoro-4-iodopyridine (CAS number 22282-75-3) is a pyridine derivative with a fluoride and an iodide at 3- and 4-positions, respectively. This dihalogenated heterocyclic building block is commonly used as a molecular scaffold for active pharmaceutical ingredients (APIs) and a substrate for synthetic chemistry. The synthesis of an antibiotic Eudistomin T involves the Suzuki coupling reaction of 3-fluoro-4-iodopyridine with (2-pivaloylaminophenyl)boronic acid, followed by lithiation to yield the trisubstituted pyridine. A cyclization reaction is then carried out to complete the formation of Eudistomin T.

3-Fluoro-4-iodopyridine is one of the key building blocks for the synthesis of β-carboline. β-Carboline finds extensive applications in anti-cancer treatments, neuroenhancement and neuroprotection.

Multiple functional groups

For facile synthesis

Fluorinated pyridine building block

For drug discovery, medicinal chemistry, and organic synthesis

Low Cost

Competitively priced, high quality product

High purity

>97% High purity

General Information

CAS Number	22282-75-3
Chemical Formula	C₅H₃FIN
Full Name	3-Fluoro-4-iodopyridine
Molecular Weight	222.99 g/mol
Synonyms	4-Iodo-3-fluoropyridine
Classification / Family	Fluorinated building blocks, Heterocyclic building blocks, Pyridine building blocks, APIs, Organic synthesis

Chemical Structure

Product Details

Purity	97%
Melting Point	T_m = 85 °C – 89 °C
Appearance	Off-White Powder/Fibres

MSDS Documentation

3-Fluoro-4-iodopyridine MSDS Sheet

Literature and Reviews

Carbolines, part VIII. An original synthesis of the antibiotic Eudistomin T, P. Rocca et al., Synth. Commun., 25 (32), 3373–3379 (1995); DOI: 10.1080/00397919508013858.
Continuous-flow divergent lithiation of 2,3-dihalopyridines: deprotolithiation versus halogen dance, T. Brégent et al., Chem. Eur. J., 28, e202202286 (2022); DOI: 10.1002/chem.202202286.
Engineering hydrogen bonding to align molecular dipoles in organic solids for efficient second harmonic generation, R. Zhao et al., Chem. Sci., 13, 12144 (2022); DOI: 10.1039/d2sc03994j.
Enantio- and Z-selective synthesis of functionalized alkenes bearing tertiary allylic stereogenic center, L. Ge et al., Sci. Adv., 9, eadf8742 (2023); DOI: 10.1126/sciadv.adf8742.

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