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5-Bromo-3-fluorosalicylaldehyde

CAS Number 251300-28-4

Chemistry Building Blocks, Fluorinated Building Blocks, Monomers


Product Code B1831-2g
Price $138 ex. VAT

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A fluorinated multifunctional building block

Used as a starting material for synthesizing Schiff base for OLED, DSSCs and bioactive compounds


5-Bromo-3-fluorosalicylaldehyde, CAS number 251300-28-4, is a derivative of salicylaldehyde (2-hydroxybenzaldehyde), bearing functional groups of both bromo- and a fluoro-halogens, a hydroxyl and carboxylic acid around the benzene ring. 5-Bromo-3-fluorosalicylaldehyde is an ideal candidate for synthesizing Schiff base which is a sub-class of imine (ketimines or aldimines). The synthesis of Schiff base starts with nucleophilic addition to the aldehyde with an amine (either aliphatic or aryl) forming a hemiaminal, then followed by dehydration to form the aldimine.

Schiff base chemical structure
Chemical structure of a 5-bromo-3-fluoro-salen ligand

The Schiff bases synthesised from 5-Bromo-3-fluorosalicylaldehyde are bidentate/tetradentate ligands. They can further form coordination complexes that are used as dyes in OLED and dye-sensitized solar cells (DSSCs with power conversion efficiency circa 7.7 %). Such complexes are also investigated in antimicrobial activities against bacteria and fungi.

Multiple functional groups

Multiple functional groups

For facile synthesis

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High purity 251300-28-4

High purity

>97% High purity

Fluorinated building block

Fluorinated salicylaldehyde building block

For OLEDs, dyes, and solar cells

General Information

CAS Number 251300-28-4
Chemical Formula C7H4BrFO2
Full Name 5-bromo-3-fluoro-2-hydroxybenzaldehyde
Molecular Weight 219.01 g/mol
Synonyms N/A
Classification / Family Fluorinated building block, Schiff base, Dyes, Semiconductor synthesis intermediates, OLED, OFETs, organic photovoltaics

Chemical Structure

5-Bromo-3-fluorosalicylaldehyde chemical structure, CAS 251300-28-4
5-Bromo-3-fluorosalicylaldehyde chemical structure, CAS 251300-28-4

Product Details

Purity >97%
Melting Point Tm = 112 °C – 116 °C
Appearance Yellow powder

MSDS Documentation

5-Bromo-3-fluorosalicylaldehyde5-Bromo-3-fluorosalicylaldehyde MSDS Sheet

Literature and Reviews

  1. Schiff bases and their complexes in organic light emitting diode application, S. Kagatikar et al., J. Electron. Mater., 50, 6708–6723(2021); DOI:10.1007/s11664-021-09197-9.
  2. Tuning the electronic and charge transport properties of Schiff base compounds by electron donor and/or acceptor groups, A. Irfan et al., Materials, 15, 8590(2022);10.3390/ma15238590.
  3. A novel class of Zn(II) Schiff base complexes with aggregation-induced emission enhancement (AIEE) properties: Synthesis, characterization and photophysical/electrochemical properties, Y.-Z. Xie et al., Dyes Pigm., 96, 467-474(2013); DOI:10.1016/j.dyepig.2012.09.020.
  4. A novel zinc complex with ethylenediamine Schiff base for highly luminance blue fluorescent OLED application, A. Gusev et al., J. Phys. Chem. C, 123(18), 11850–11859(2019); DOI:10.1021/acs.jpcc.9b02171.
  5. Energy materials based on metal Schiff base complexes, J. Zhang et al., Coordination Chemistry Reviews, 355, 180–198(2018); DOI:10.1016/j.ccr.2017.08.007.
  6. Synthesis, characterization and antimicrobial activities of Cu(II), Ni(II) and Co(II) complexes with N–O donor ligand, V. Gupta et al., Asian J. Pharm. Tech., 4(4), 205-210(2014); DOI: 10.5958/2231–5713.
  7. Schiff bases: versatile motifs of synthetic and biological interest, K. Kumar et al., J. Pharm. Biol. Sci., 16(4), 47-55(2021); DOI: 10.9790/3008-1604024755.

To the best of our knowledge the information provided here is accurate. The values provided are typical at the time of manufacture and may vary over time and from batch to batch. Products may have minor cosmetic differences (e.g. to the branding) compared to the photos on our website. All products are for laboratory and research and development use only.

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