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Product Code B2861-10g
Price $113 ex. VAT

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A fluorinated nicotinonitrile building block

Used for the synthesis of bicyclic heterocycles in medicinal chemistry


2-Fluoropyridine-3-carbonitrile (CAS number 3939-13-7), also named as 2-fluoronicotinonitrile, is a nicotinonitrile building block featuring a fluoride substituent at 2-position. 2-Fluoropyridine-3-carbonitrile commonly serves as a synthesis precursor for active pharmaceutical ingredients (APIs), such as niflumic acid that is used for joint and muscular pain relief. Pyrazopyridine, a bicyclic heterocycle can be synthesised from 2-fluoropyridine-3-carbonitrile. The reaction begins with a nucleophilic aromatic substitution of hydrazine, followed by a pyrazole cyclisation reaction.

Additionally, 2-fluoropyridine-3-carbonitrile can be modified through Minisci reaction for meta- and para-alkylation.

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated building block

Fluorinated hydroxybenzoic acid building block

For drug discovery, medicinal chemistry and biochemistry research

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High purity 3939-13-7

High purity

>98% High purity

General Information

CAS Number 3939-13-7
Chemical Formula C6H3FN2
Full Name 2-Fluoronicotinonitrile
Molecular Weight 122.10 g/mol
Synonyms 3-Cyano-2-fluoropyridine
Classification / Family Fluorinated building blocks, Heterocyclic building blocks, Nicotinonitrile building blocks, APIs

Chemical Structure

2-Fluoropyridine-3-carbonitrile chemical structure, CAS 3939-13-7.
2-Fluoropyridine-3-carbonitrile chemical structure, CAS 3939-13-7

Product Details

Purity 98%
Melting Point Tm = 28 °C – 33 °C
Appearance White crystals

MSDS Documentation

2-Fluoropyridine-3-carbonitrile2-Fluoropyridine-3-carbonitrile MSDS Sheet

Literature and Reviews

  1. Antiproliferative activity of some newly synthesized substituted pyridine candidates using 4‑(aryl)-6-(naphthalen-1-yl)-2-oxo-1,2-dihydropyridine-3-carbonitrile as synthon, A. El-Sayed et al., ACS Omega, 6, 7147–7156(2021); DOI: 10.1021/acsomega.1c00202.
  2. Second-generation CD73 inhibitors based on a 4,6-biaryl-2-thiophyridine scaffold, R. Ghoteimi et al., ChemMedChem, 18, e202200594(2023); DOI: 10.1002/cmdc.202200594.
  3. New reactions of 5-amino-3-(cyanomethyl)-1H-pyrazole-4-carbonitrile, V. Dotsenko et al., Chem. Proc., 3, 23(2023); DOI: 10.3390/ecsoc-24-08398.
  4. Synthesis, tumor inhibitory and antioxidant activity of new polyfunctionally 2-substituted 5,6,7,8-tetrahydronaphthalene derivatives containing pyridine, thioxopyridine and pyrazolopyridine moieties, N. Hamdy et al., Acta Pol. Pharm., 70(6), 987–1001(2013); ISSN: 0001-6837.
  5. Synthesis and bioactivity of novel amino-pyrazolopyridines, B. Orlikova et al., Eur. J. Med. Chem., 85, 450–457(2014); DOI: 10.1016/j.ejmech.2014.08.008.

To the best of our knowledge the information provided here is accurate. The values provided are typical at the time of manufacture and may vary over time and from batch to batch. Products may have minor cosmetic differences (e.g. to the branding) compared to the photos on our website. All products are for laboratory and research and development use only.

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