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Product Code B2861-10g
Price £90 ex. VAT

A fluorinated nicotinonitrile building block

Used for the synthesis of bicyclic heterocycles in medicinal chemistry

Specifications | MSDS | Literature and Reviews

2-Fluoropyridine-3-carbonitrile (CAS number 3939-13-7), also named as 2-fluoronicotinonitrile, is a nicotinonitrile building block featuring a fluoride substituent at 2-position. 2-Fluoropyridine-3-carbonitrile commonly serves as a synthesis precursor for active pharmaceutical ingredients (APIs), such as niflumic acid that is used for joint and muscular pain relief. Pyrazopyridine, a bicyclic heterocycle can be synthesised from 2-fluoropyridine-3-carbonitrile. The reaction begins with a nucleophilic aromatic substitution of hydrazine, followed by a pyrazole cyclisation reaction.

Additionally, 2-fluoropyridine-3-carbonitrile can be modified through Minisci reaction for meta- and para-alkylation.

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated building block

Fluorinated hydroxybenzoic acid building block

For drug discovery, medicinal chemistry and biochemistry research

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High purity 3939-13-7

High purity

>98% High purity

General Information

CAS Number 3939-13-7
Chemical Formula C6H3FN2
Full Name 2-Fluoronicotinonitrile
Molecular Weight 122.10 g/mol
Synonyms 3-Cyano-2-fluoropyridine
Classification / Family Fluorinated building blocks, Heterocyclic building blocks, Nicotinonitrile building blocks, APIs

Chemical Structure

2-Fluoropyridine-3-carbonitrile chemical structure, CAS 3939-13-7.
2-Fluoropyridine-3-carbonitrile chemical structure, CAS 3939-13-7

Product Details

Purity 98%
Melting Point Tm = 28 °C – 33 °C
Appearance White crystals

MSDS Documentation

2-Fluoropyridine-3-carbonitrile2-Fluoropyridine-3-carbonitrile MSDS Sheet

Literature and Reviews

  1. Antiproliferative activity of some newly synthesized substituted pyridine candidates using 4‑(aryl)-6-(naphthalen-1-yl)-2-oxo-1,2-dihydropyridine-3-carbonitrile as synthon, A. El-Sayed et al., ACS Omega, 6, 7147–7156(2021); DOI: 10.1021/acsomega.1c00202.
  2. Second-generation CD73 inhibitors based on a 4,6-biaryl-2-thiophyridine scaffold, R. Ghoteimi et al., ChemMedChem, 18, e202200594(2023); DOI: 10.1002/cmdc.202200594.
  3. New reactions of 5-amino-3-(cyanomethyl)-1H-pyrazole-4-carbonitrile, V. Dotsenko et al., Chem. Proc., 3, 23(2023); DOI: 10.3390/ecsoc-24-08398.
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