FREE shipping to on qualifying orders when you spend or more, processed by Ossila BV. All prices ex. VAT. Qualifying orders ship free worldwide! Fast, secure, and backed by the Ossila guarantee. It looks like you are visiting from , click to shop in or change country. Orders to the EU are processed by our EU subsidiary.

It looks like you are using an unsupported browser. You can still place orders by emailing us on info@ossila.com, but you may experience issues browsing our website. Please consider upgrading to a modern browser for better security and an improved browsing experience.


Product Code B2861-10g
Price £90 ex. VAT

A fluorinated nicotinonitrile building block

Used for the synthesis of bicyclic heterocycles in medicinal chemistry


Specifications | MSDS | Literature and Reviews


2-Fluoropyridine-3-carbonitrile (CAS number 3939-13-7), also named as 2-fluoronicotinonitrile, is a nicotinonitrile building block featuring a fluoride substituent at 2-position. 2-Fluoropyridine-3-carbonitrile commonly serves as a synthesis precursor for active pharmaceutical ingredients (APIs), such as niflumic acid that is used for joint and muscular pain relief. Pyrazopyridine, a bicyclic heterocycle can be synthesised from 2-fluoropyridine-3-carbonitrile. The reaction begins with a nucleophilic aromatic substitution of hydrazine, followed by a pyrazole cyclisation reaction.

Additionally, 2-fluoropyridine-3-carbonitrile can be modified through Minisci reaction for meta- and para-alkylation.

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated building block

Fluorinated hydroxybenzoic acid building block

For drug discovery, medicinal chemistry and biochemistry research

Worldwide shipping for 3939-13-7

Worldwide shipping

Quick and reliable shipping

High purity 3939-13-7

High purity

>98% High purity

General Information


CAS Number 3939-13-7
Chemical Formula C6H3FN2
Full Name 2-Fluoronicotinonitrile
Molecular Weight 122.10 g/mol
Synonyms 3-Cyano-2-fluoropyridine
Classification / Family Fluorinated building blocks, Heterocyclic building blocks, Nicotinonitrile building blocks, APIs

Chemical Structure


2-Fluoropyridine-3-carbonitrile chemical structure, CAS 3939-13-7.
2-Fluoropyridine-3-carbonitrile chemical structure, CAS 3939-13-7

Product Details


Purity 98%
Melting Point Tm = 28 °C – 33 °C
Appearance White crystals

MSDS Documentation


2-Fluoropyridine-3-carbonitrile2-Fluoropyridine-3-carbonitrile MSDS Sheet

Literature and Reviews


  1. Antiproliferative activity of some newly synthesized substituted pyridine candidates using 4‑(aryl)-6-(naphthalen-1-yl)-2-oxo-1,2-dihydropyridine-3-carbonitrile as synthon, A. El-Sayed et al., ACS Omega, 6, 7147–7156(2021); DOI: 10.1021/acsomega.1c00202.
  2. Second-generation CD73 inhibitors based on a 4,6-biaryl-2-thiophyridine scaffold, R. Ghoteimi et al., ChemMedChem, 18, e202200594(2023); DOI: 10.1002/cmdc.202200594.
  3. New reactions of 5-amino-3-(cyanomethyl)-1H-pyrazole-4-carbonitrile, V. Dotsenko et al., Chem. Proc., 3, 23(2023); DOI: 10.3390/ecsoc-24-08398.
Return to the top