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2,4,6-Trifluorophenylacetic acid

CAS Number 209991-63-9

Chemistry Building Blocks, Fluorinated Building Blocks, Materials, Monomers

Product Code B2881-250mg
Price £90 ex. VAT

A trifluorinated phenylacetic acid building block

Used as an intermediate for the preparation of APIs and agricultural fungicides

Specifications | MSDS | Literature and Reviews

2,4,6-Trifluorophenylacetic acid (CAS number 209991-63-9) is a derivative of phenylacetic acid with fluorine substitutions at 2-, 4- and 6-positions. 2,4,6-Trifluorophenylacetic acid readily couples with amines, catalysed by N-hydroxysuccinimide and N,N'-diisopropylcarbodiimide. Glucosamine-based supramolecular nanotubes is prepared with this method, demonstrating effective human mesenchylmal cell therapy.

Additionally, 2,4,6-trifluorophenylacetic acid is employed in the synthesis of pyridazines for agricultural fungicides. The preparation begins with a reaction of 2,4,6-trifluorophenylacetic acid and phenylglyoxylic acid under basic condition to form a furandione derivative. The fungicide is then obtained from a reaction of the resulting furandione and hydrazine.

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated building block

Fluorinated phenylacetic acid building block

for drug discovery, medicinal chemistry and biochemistry research

Worldwide shipping for 209991-63-9

Worldwide shipping

Quick and reliable shipping

High purity 209991-63-9

High purity

>98% High purity

General Information

CAS Number 209991-63-9
Chemical Formula C8H5F3O2
Full Name 2,4,6-Trifluorophenylacetic acid
Molecular Weight 190.12 g/mol
Synonyms 2,4,6-Trifluorobenzeneacetic acid
Classification / Family Fluorinated building blocks, Phenylacetic acid building blocks, APIs, Fungicides, Heterocycles

Chemical Structure

2,4,6-Trifluorophenylacetic acid chemical structure, CAS 209991-63-9.
2,4,6-Trifluorophenylacetic acid chemical structure, CAS 209991-63-9

Product Details

Purity 98%
Melting Point Tm = 110 °C – 112 °C
Appearance White crystals

MSDS Documentation

2,4,6-Trifluorophenylacetic acid2,4,6-Trifluorophenylacetic acid MSDS Sheet

Literature and Reviews

  1. Discovery of pyridachlometyl: A new class of pyridazine fungicides, A. Manabe et al., Bioorg. Med. Chem., 88, 117332(2023); DOI: 10.1016/j.bmc.2023.117332.
  2. Glucosamine-based supramolecular nanotubes for human mesenchymal cell therapy, S. Talloj, ACS Appl. Mater. Interfaces, 10(17), 15079–15087(2018); DOI: 10.1021/acsami.8b03226.
  3. Atogepant, P. Martelletti et al., Drugs Future, 45(5), 1–13(2020); DOI: 10.1358/dof.2020.45.5.3123467.

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