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2,4,6-Trifluorophenylacetic acid

CAS Number 209991-63-9

Chemistry Building Blocks, Fluorinated Building Blocks, Monomers


Product Code B2881-250mg
Price $113 ex. VAT

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A trifluorinated phenylacetic acid building block

Used as an intermediate for the preparation of APIs and agricultural fungicides


2,4,6-Trifluorophenylacetic acid (CAS number 209991-63-9) is a derivative of phenylacetic acid with fluorine substitutions at 2-, 4- and 6-positions. 2,4,6-Trifluorophenylacetic acid readily couples with amines, catalysed by N-hydroxysuccinimide and N,N'-diisopropylcarbodiimide. Glucosamine-based supramolecular nanotubes is prepared with this method, demonstrating effective human mesenchylmal cell therapy.

Additionally, 2,4,6-trifluorophenylacetic acid is employed in the synthesis of pyridazines for agricultural fungicides. The preparation begins with a reaction of 2,4,6-trifluorophenylacetic acid and phenylglyoxylic acid under basic condition to form a furandione derivative. The fungicide is then obtained from a reaction of the resulting furandione and hydrazine.

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated building block

Fluorinated phenylacetic acid building block

for drug discovery, medicinal chemistry and biochemistry research

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High purity 209991-63-9

High purity

>98% High purity

General Information

CAS Number 209991-63-9
Chemical Formula C8H5F3O2
Full Name 2,4,6-Trifluorophenylacetic acid
Molecular Weight 190.12 g/mol
Synonyms 2,4,6-Trifluorobenzeneacetic acid
Classification / Family Fluorinated building blocks, Phenylacetic acid building blocks, APIs, Fungicides, Heterocycles

Chemical Structure

2,4,6-Trifluorophenylacetic acid chemical structure, CAS 209991-63-9.
2,4,6-Trifluorophenylacetic acid chemical structure, CAS 209991-63-9

Product Details

Purity 98%
Melting Point Tm = 110 °C – 112 °C
Appearance White crystals

MSDS Documentation

2,4,6-Trifluorophenylacetic acid2,4,6-Trifluorophenylacetic acid MSDS Sheet

Literature and Reviews

  1. Discovery of pyridachlometyl: A new class of pyridazine fungicides, A. Manabe et al., Bioorg. Med. Chem., 88, 117332(2023); DOI: 10.1016/j.bmc.2023.117332.
  2. Glucosamine-based supramolecular nanotubes for human mesenchymal cell therapy, S. Talloj, ACS Appl. Mater. Interfaces, 10(17), 15079–15087(2018); DOI: 10.1021/acsami.8b03226.
  3. Atogepant, P. Martelletti et al., Drugs Future, 45(5), 1–13(2020); DOI: 10.1358/dof.2020.45.5.3123467.
  4. Synthesis and fungicidal activity of tubulin polymerisation promoters. Part 2: pyridazines, C. Lamberth et al., Bioorg. Med. Chem., 20, 2803–2810(2012); DOI: 10.1016/j.bmc.2012.03.035.

To the best of our knowledge the information provided here is accurate. The values provided are typical at the time of manufacture and may vary over time and from batch to batch. Products may have minor cosmetic differences (e.g. to the branding) compared to the photos on our website. All products are for laboratory and research and development use only.

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