2,4,6-Trifluorophenylacetic acid

CAS Number 209991-63-9

Chemistry Building Blocks, Fluorinated Building Blocks, Monomers

2,4,6-Trifluorophenylacetic acid CAS 209991-63-9

A trifluorinated phenylacetic acid building block

Used as an intermediate for the preparation of APIs and agricultural fungicides

Overview
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2,4,6-Trifluorophenylacetic acid (CAS number 209991-63-9) is a derivative of phenylacetic acid with fluorine substitutions at 2-, 4- and 6-positions. 2,4,6-Trifluorophenylacetic acid readily couples with amines, catalysed by N-hydroxysuccinimide and N,N'-diisopropylcarbodiimide. Glucosamine-based supramolecular nanotubes is prepared with this method, demonstrating effective human mesenchylmal cell therapy.

Additionally, 2,4,6-trifluorophenylacetic acid is employed in the synthesis of pyridazines for agricultural fungicides. The preparation begins with a reaction of 2,4,6-trifluorophenylacetic acid and phenylglyoxylic acid under basic condition to form a furandione derivative. The fungicide is then obtained from a reaction of the resulting furandione and hydrazine.

Multiple functional groups

For facile synthesis

Fluorinated phenylacetic acid building block

for drug discovery, medicinal chemistry and biochemistry research

Worldwide shipping

Quick and reliable shipping

High purity

>98% High purity

General Information

CAS Number	209991-63-9
Chemical Formula	C₈H₅F₃O₂
Full Name	2,4,6-Trifluorophenylacetic acid
Molecular Weight	190.12 g/mol
Synonyms	2,4,6-Trifluorobenzeneacetic acid
Classification / Family	Fluorinated building blocks, Phenylacetic acid building blocks, APIs, Fungicides, Heterocycles

Chemical Structure

Product Details

Purity	98%
Melting Point	T_m = 110 °C – 112 °C
Appearance	White crystals

MSDS Documentation

2,4,6-Trifluorophenylacetic acid MSDS Sheet

Literature and Reviews

Discovery of pyridachlometyl: A new class of pyridazine fungicides, A. Manabe et al., Bioorg. Med. Chem., 88, 117332(2023); DOI: 10.1016/j.bmc.2023.117332.
Glucosamine-based supramolecular nanotubes for human mesenchymal cell therapy, S. Talloj, ACS Appl. Mater. Interfaces, 10(17), 15079–15087(2018); DOI: 10.1021/acsami.8b03226.
Atogepant, P. Martelletti et al., Drugs Future, 45(5), 1–13(2020); DOI: 10.1358/dof.2020.45.5.3123467.
Synthesis and fungicidal activity of tubulin polymerisation promoters. Part 2: pyridazines, C. Lamberth et al., Bioorg. Med. Chem., 20, 2803–2810(2012); DOI: 10.1016/j.bmc.2012.03.035.

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