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5-Cyano-2-fluoropyridine

CAS Number 3939-12-6

Fluorinated Building Blocks, Heterocyclic Building Blocks, Monomers


Product Code B2771-1g
Price $113 ex. VAT

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A fluorinated pyridine building block

Used for the synthesis of APIs and diketopyrrolopyrrole dyes


5-Cyano-2-fluoropyridine (CAS number 3939-12-6) is a pyridine derivative with a fluorine and a nitrile at 2- and 5-positions. An anti-cancer Ube2T inhibitor is synthesised from 5-cyano-2-fluoropyridine through a two-step reaction process. The synthesis begins with the reaction of 5-cyano-2-fluoropyridine and pyrrolidine via nucleophilic aromatic substitution, followed by Pinner reaction to yield the amidine moiety.

5-Cyano-2-fluoropyridine is also employed in the synthesis of pyridine substituted dikeopyrrolopyrroles (DPPs) using diisopropyl succinate. The resulting pyridine-DPPs have bathochromically shifted absorption and emission bands.

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated building block

Fluorinated nicotinonitrile building block

for drug discovery, bioimaging dyes and biochemistry research

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High purity 3939-12-6

High purity

>97% High purity

General Information

CAS Number 3939-12-6
Chemical Formula C6H3FN2
Full Name 5-Cyano-2-fluoropyridine
Molecular Weight 122.10 g/mol
Synonyms 6-Fluoronicotinonitrile, 6-fluoropyridine-3-carbonitrile
Classification / Family Fluorinated building blocks, Heterocyclic building blocks, APIs, Dyes

Chemical Structure

5-Cyano-2-fluoropyridine chemical structure, CAS 3939-12-6.
5-Cyano-2-fluoropyridine chemical structure, CAS 3939-12-6

Product Details

Purity 97%
Melting Point Tm = 51 °C – 52 °C
Appearance White crystals

MSDS Documentation

5-Cyano-2-fluoropyridine5-Cyano-2-fluoropyridine MSDS Sheet

Literature and Reviews

  1. Discovery of a highly potent and selective dual PROTAC degrader of CDK12 and CDK13, J. Yang et al., J. Med. Chem., 65, 11066–11083(2022); DOI: 10.1021/acs.jmedchem.2c00384.
  2. Mind the metal: a fragment library-derived zinc impurity binds the E2 ubiquitin-conjugating enzyme Ube2T and induces structural rearrangements, J. Med. Chem., 60, 8183–8191(2017); DOI: 10.1021/acs.jmedchem.7b01071.
  3. The impact of the interplay between steric and electronic effects on the synthesis and optical properties of diketopyrrolopyrroles bearing pyridine moieties, O. Vakuliuk et al., ChemPhotoChem, 1, 243–252(2017); DOI: 10.1002/cptc.201600047.
  4. Design, synthesis and antimycobacterial activity of novel nitrobenzamide derivatives, H. Wang et al., Chin. Chem. Lett., 30(2), 413–416(2019); DOI: 10.1016/j.cclet.2018.08.005.

To the best of our knowledge the information provided here is accurate. The values provided are typical at the time of manufacture and may vary over time and from batch to batch. Products may have minor cosmetic differences (e.g. to the branding) compared to the photos on our website. All products are for laboratory and research and development use only.

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