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Product Code B1691-25g
Price $125 ex. VAT

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A fluorinated heterocyclic building block

Used as a synthesis intermediate for APIs and dyes in application of drug discovery and photonics


3-(4-Fluorophenyl)-1-isopropylindole (CAS number 93957-49-4) is a derivative of indole, a heterobicyclic compound, with a 4-fluorophenyl (3-position) and an isopropyl substituent (1-position). 3-(4-Fluorophenyl)-1-isopropylindole is the nucleus of Fluvastatin, a drug used to treat hypercholesterolemia for preventing cardiovascular diseases. A series of 3-(4-Fluorophenyl)-1-isopropylindole derivatives are synthesized, presenting a significant decrease of serum total cholesterol, triglycerides, and low-density lipoprotein levels. The syntheses involve a Vilsmeier-Haack reaction for introducing an aldehyde to the 2-position and then a Claisen-Schmidt condensation for the modification of the aldehyde.

Chemical structure of Fluvastatin
Chemical structure of Fluvastatin, a drug for treating hypercholesterolemia

3-(4-Fluorophenyl)-1-isopropylindole also shows non-linear optical properties. The electron-withdrawing substituent of indole increases the hyperpolarizability coefficient, thus resulting a better non-linear optical response.

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated building block

Fluorinated indole building block

For drug discovery, biochemistry, and photonics

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High purity 93957-49-4

High purity

>97% High purity

General Information

CAS Number 93957-49-4
Chemical Formula C17H16FN
Full Name 3-(4-Fluorophenyl)-1-isopropyl-1H-indole
Molecular Weight 253.32 g/mol
Synonyms 1-Isopropyl-3-(4-fluorophenyl)indole
Classification / Family Fluorinated building block, heterocyclic building block, APIs, Photonics

Chemical Structure

3-(4-Fluorophenyl)-1-isopropylindole chemical structure, CAS 93957-49-4
3-(4-Fluorophenyl)-1-isopropylindole chemical structure, CAS 93957-49-4

Product Details

Purity 97%
Melting Point Tm = 95 °C – 98 °C
Appearance Off-white to pale beige powder

MSDS Documentation

3-(4-Fluorophenyl)-1-isopropylindole3-(4-Fluorophenyl)-1-isopropylindole MSDS Sheet

Literature and Reviews

  1. Interaction of indole derivative with human serum albumin: a combined spectroscopic and molecular dynamics study, S. Pawar et al., ChemistrySelect, 3, 12080–12088(2008); DOI: 10.1002/slct.201802466.
  2. Optical properties of 3-substituted indoles, J. Kumar et al., RSC Adv., 10, 28213(2020); DOI: 10.1039/d0ra05405d.
  3. Photoredox cyanomethylation of indoles: catalyst modification and mechanism, O'Brien et al., J. Org. Chem., 83(16), 8926–8935(2018); DOI: 10.1021/acs.joc.8b01146.
  4. Synthesis, crystal studies and in vivo anti-hyperlipidemic activities of indole derivatives containing Fluvastatin nucleus, V Kumar et al., RSC Adv., 5, 38748(2015); DOI: 10.1039/c5ra02908b

To the best of our knowledge the information provided here is accurate. The values provided are typical at the time of manufacture and may vary over time and from batch to batch. Products may have minor cosmetic differences (e.g. to the branding) compared to the photos on our website. All products are for laboratory and research and development use only.

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