FREE shipping to on qualifying orders when you spend or more, processed by Ossila BV. All prices ex. VAT. Qualifying orders ship free worldwide! Fast, secure, and backed by the Ossila guarantee. It looks like you are visiting from , click to shop in or change country. Orders to the EU are processed by our EU subsidiary.

It looks like you are using an unsupported browser. You can still place orders by emailing us on, but you may experience issues browsing our website. Please consider upgrading to a modern browser for better security and an improved browsing experience.

Product Code B2971
Price £95 ex. VAT

A fluorinated quinoline derivative

An intermediate for the preparation of APIs for anti-cancer treatments, dyes for OLEDs and solar cells applications.

Specifications | MSDS | Literature and Reviews

4-Bromo-6-fluoroquinoline (CAS number 661463-17-8) is a dihalogenated quinoline, a benzene-fused pyridine bicyclic heterocycle. Quinoline derivatives are widely used as active pharmaceutical ingredients (APIs). 4-Bromo-6-fluoroquinoline is applied in the synthesis of linrodostat, an inhibitor of indoleamine 2,3-dioxygenase for anti-cancer treatments. The reactivity of 4-bromo-6-fluoroquinoline includes Pd-catalysed coupling reactions on the bromide group and nucleophilic aromatic substitution on the fluoride group.

As an aromatic bicyclic compound, 4-bromo-6-fluoroquinoline can also be used in the preparation of dyes for the applications of OLEDs and solar cells.

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated building block

Fluorinated pyridine building block

For drug discovery, medicinal chemistry and biochemistry research

Worldwide shipping for 661463-17-8

Worldwide shipping

Quick and reliable shipping

High purity

High purity

>98% High purity

General Information

CAS Number 661463-17-8
Chemical Formula C9H5BrFN
Full Name 4-Bromo-6-fluoroquinoline
Molecular Weight 226.05 g/mol
Synonyms N/A
Classification / Family Fluorinated building blocks, Heterocyclic building blocks, Quinoline building blocks, APIs, Dyes

Chemical Structure

4-Bromo-6-fluoroquinoline chemical structure, CAS 661463-17-8.
4-Bromo-6-fluoroquinoline chemical structure, CAS 661463-17-8

Product Details

Purity 98%
Melting Point Tm = 77 °C – 78 °C
Appearance Off-white powder

MSDS Documentation

4-Bromo-6-fluoroquinoline4-Bromo-6-fluoroquinoline MSDS Sheet

Literature and Reviews

  1. Rapid development of a commercial process for linrodostat, an indoleamine 2,3-dioxygenase (IDO) inhibitor, K. Fraunhoffer et al., Org. Process Res. Dev., 23(11), 2482–2498(2019), DOI: 10.1021/acs.oprd.9b00359.
  2. Discovery of IACS-9779 and IACS-70465 as potent inhibitors targeting indoleamine 2,3-dioxygenase 1 (IDO1) apoenzyme, M. Hamilton et al., J. Med. Chem., 64(15), 11302–11329(2021); DOI: 10.1021/acs.jmedchem.1c00679.
  3. Preclinical characterization of linrodostat mesylate, a novel, potent, and selective oral indoleamine 2,3-dioxygenase 1 inhibitor, A. Balog et al., Mol. Cancer Ther., 20, 467–476(2021); DOI: 10.1158/1535-7163.MCT-20-0251.

Return to the top