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5-Bromo-3-fluoropyridine-2-carboxylic acid

CAS Number 669066-91-5

Chemistry Building Blocks, Fluorinated Building Blocks, Heterocyclic Building Blocks, Materials, Monomers

Product Code B3411-1g
Price £55 ex. VAT

A fluorinated pyridinecarboxylic acid building block

As a synthesis intermediate for organometallic complexes used in catalysts and photoluminescent dyes

Specifications | MSDS | Literature and Reviews

5-Bromo-3-fluoropyridine-2-carboxylic acid (CAS number 669066-91-5), also referred to as 5-bromo-3-fluoropicolinic acid, is a dihalogenated picolinic acid. 5-Bromo-3-fluoropyridine-2-carboxylic acid can be used in the synthesis of allosteric adenosine A2A receptors for insomnia treatments.

5-Bromo-3-fluoropyridine-2-carboxylic acid is also utilised to prepare pyridine-triazole derivatives that coordinate to rhenium (Re) for photoluminescent materials. The reaction begins with the synthesis of pyridinehydrazide, followed by the formation of pyridine-oxadiazol using triethyl orthoformate. The resulting pyridine-oxadiazole then reacts with aniline derivatives to yield the pyridine-triazole ligands. The Re-pyridine-triazole complexes exhibit a photoluminescence quantum yield of up to 55%.

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated picolinic acid building block

Fluorinated picolinic acid building block

For catalysts, organometallic complexes, and photoluminescence dyes

competitively priced 669066-91-5

Low Cost

Competitively priced, high quality product

High purity 669066-91-5

High purity

>98% High purity

General Information

CAS Number 669066-91-5
Chemical Formula C6H3BrFNO2
Full Name 5-Bromo-3-fluoro-2-pyridinecarboxylic acid
Molecular Weight 220.00 g/mol
Synonyms 5-Bromo-3-fluoropicolinic acid, 5-Bromo-2-carboxy-3-fluoropyridine, 5-Bromo-3-fluoropyridin-2-carboxylic acid
Classification / Family Fluorinated building blocks, Pyridine building blocks, Carboxylic acid building blocks, Organometallic complexes, Catalysts, Photoluminescence dyes

Chemical Structure

5-Bromo-3-fluoropyridine-2-carboxylic acid chemical structure, CAS 669066-91-5
5-Bromo-3-fluoropyridine-2-carboxylic acid chemical structure, CAS 669066-91-5

Product Details

Purity 98%
Melting Point Tm = 175 °C – 180 °C
Appearance Off-white Powder

MSDS Documentation

5-Bromo-3-fluoropyridine-2-carboxylic acid5-Bromo-3-fluoropyridine-2-carboxylic acid MSDS Sheet

Literature and Reviews

  1. Structural comparison of geometrical isomers of N’-(1H-imidazol-4-ylmethylene)picolinohydrazide and their mononuclear and dinuclear cobalt(III) complexes, D. Acheampong et al., Results Chem., 100798 (2023); DOI: 10.1016/j.rechem.2023.100798.
  2. Positive allosteric adenosine A2A receptor modulation suppresses insomnia associated with mania-and schizophrenia-like behaviors in mice, Y. Lin et al., Front. Pharmacol., 14, 1138666 (2023); DOI: 10.3389/fphar.2023.1138666.
  3. Tuning the photoluminescence properties of SLE- and MRL-active tricarbonylrhenium(I) complexes through minor structural changes of the organic ligand, A. Poirot et al., J. Photochem. Photobiol., A, 445, 114982 (2023); DOI: 10.1016/j.jphotochem.2023.114982.

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