5-Bromo-3-fluoropyridine-2-carboxylic acid

CAS Number 669066-91-5

Chemistry Building Blocks, Fluorinated Building Blocks, Heterocyclic Building Blocks, Monomers

5-Bromo-3-fluoropyridine-2-carboxylic acid MSDS

5-Bromo-3-fluoropyridine-2-carboxylic acid CAS 669066-91-5

A fluorinated pyridinecarboxylic acid building block

As a synthesis intermediate for organometallic complexes used in catalysts and photoluminescent dyes

Overview
Related Products

5-Bromo-3-fluoropyridine-2-carboxylic acid (CAS number 669066-91-5), also referred to as 5-bromo-3-fluoropicolinic acid, is a dihalogenated picolinic acid. 5-Bromo-3-fluoropyridine-2-carboxylic acid can be used in the synthesis of allosteric adenosine A_2A receptors for insomnia treatments.

5-Bromo-3-fluoropyridine-2-carboxylic acid is also utilised to prepare pyridine-triazole derivatives that coordinate to rhenium (Re) for photoluminescent materials. The reaction begins with the synthesis of pyridinehydrazide, followed by the formation of pyridine-oxadiazol using triethyl orthoformate. The resulting pyridine-oxadiazole then reacts with aniline derivatives to yield the pyridine-triazole ligands. The Re-pyridine-triazole complexes exhibit a photoluminescence quantum yield of up to 55%.

Multiple functional groups

For facile synthesis

Fluorinated picolinic acid building block

For catalysts, organometallic complexes, and photoluminescence dyes

Low Cost

Competitively priced, high quality product

High purity

>98% High purity

General Information

CAS Number	669066-91-5
Chemical Formula	C₆H₃BrFNO₂
Full Name	5-Bromo-3-fluoro-2-pyridinecarboxylic acid
Molecular Weight	220.00 g/mol
Synonyms	5-Bromo-3-fluoropicolinic acid, 5-Bromo-2-carboxy-3-fluoropyridine, 5-Bromo-3-fluoropyridin-2-carboxylic acid
Classification / Family	Fluorinated building blocks, Pyridine building blocks, Carboxylic acid building blocks, Organometallic complexes, Catalysts, Photoluminescence dyes

Chemical Structure

Product Details

Purity	98%
Melting Point	T_m = 175 °C – 180 °C
Appearance	Off-white Powder

MSDS Documentation

5-Bromo-3-fluoropyridine-2-carboxylic acid MSDS Sheet

Literature and Reviews

Structural comparison of geometrical isomers of N’-(1H-imidazol-4-ylmethylene)picolinohydrazide and their mononuclear and dinuclear cobalt(III) complexes, D. Acheampong et al., Results Chem., 100798 (2023); DOI: 10.1016/j.rechem.2023.100798.
Positive allosteric adenosine A_2A receptor modulation suppresses insomnia associated with mania-and schizophrenia-like behaviors in mice, Y. Lin et al., Front. Pharmacol., 14, 1138666 (2023); DOI: 10.3389/fphar.2023.1138666.
Tuning the photoluminescence properties of SLE- and MRL-active tricarbonylrhenium(I) complexes through minor structural changes of the organic ligand, A. Poirot et al., J. Photochem. Photobiol., A, 445, 114982 (2023); DOI: 10.1016/j.jphotochem.2023.114982.
Synthesis and characterization of chiral iridium complexes bearing carbohydrate functionalized pyridincarboxamide ligands and their application as catalysts in the asymmetric transfer hydrogenation of α‑ketoacids in water, L. Tensi et al., Organometallics, 42, 157–166 (2023); DOI: 10.1021/acs.organomet.2c00544.

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