4-Hydroxy-2-(trifluoromethyl)benzoic acid

CAS Number 320-32-1

4-Hydroxy-2-(trifluoromethyl)benzoic acid CAS 320-32-1

A trifluoromethylated benzoic acid building block

For synthesising functional polymers, liquid crystal and APIs

Overview
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4-Hydroxy-2-(trifluoromethyl)benzoic acid (CAS number 320-32-1) has hydroxyl, carboxylic acid and trifluoromethyl functional groups on the benzene ring. The carboxylic acid and hydroxyl groups are in the para-position, enabling it to synthesis linear molecules. Polyesters with segments of 4-hydroxy-2-(trifluoromethyl)benzoic acid self-assemble to form spherulite crystals for the fabrication of optical vortex beam generator. 4-Hydroxy-2-(trifluoromethyl)benzoic acid reacts with alkylated acyl chloride for the synthesis of smectic C liquid crystals.

Additionally, 4-hydroxy-2-(trifluoromethyl)benzoic acid can be attached to molecular scaffolds, such as benzofuran derivatives, through esterification and amide synthesis for producing active pharmaceutical ingredients (APIs) as antitubercular agents.

Multiple functional groups

For facile synthesis

Fluorinated benzoic acid building block

for drug discovery, liquid crystals, and biochemistry research

Worldwide shipping

Quick and reliable shipping

High purity

>98% High purity

General Information

CAS Number	320-32-1
Chemical Formula	C₈H₅F₃O₃
Full Name	4-Hydroxy-2-(trifluoromethyl)benzoic acid
Molecular Weight	206.12 g/mol
Synonyms	α,α,α-Trifluoro-4-hydroxy-o-toluic acid, 4-Carboxy-3-(trifluoromethyl)phenol
Classification / Family	Fluorinated building blocks, Benzoic acid building blocks, Phenol building blocks, Heterocycles, Liquid crystals, APIs

Chemical Structure

Product Details

Purity	98%
Melting Point	T_m = 159 °C – 161 °C
Appearance	White powder

MSDS Documentation

4-Hydroxy-2-(trifluoromethyl)benzoic acid MSDS Sheet

Literature and Reviews

Design, in-silico study and biological evaluation of newly synthesized 3-chlorobenzofuran congeners as antitubercular agents, M. Abdullah et al., Arab. J. Chem., 14, 103034(2021); DOI: 10.1016/j.arabjc.2021.103034.
Optical vortices enabled by structural vortices, Y. Liu et al., arXiv:2306.03359(2023); DOI: 10.48550/arXiv.2306.03359.
Comprehensive review on coumarins: molecules of potential chemical and pharmacological interest, K. Kumar et al., J Chem Pharm Res, 7(9), 67–81(2015); ISSN : 0975-7384.
First mesomorphic and DFT characterizations for 3- (or 4-) n-alkanoyloxy benzoic acids and their optical applications, M. El-Atawy et al., Heliyon, 9, e19384(2023); DOI: 10.1016/j.heliyon.2023.e19384.

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