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4-Hydroxy-2-(trifluoromethyl)benzoic acid

CAS Number 320-32-1

Fluorinated Building Blocks, Materials, Monomers


Product Code B2931-1g
Price £65 ex. VAT

A trifluoromethylated benzoic acid building block

For synthesising functional polymers, liquid crystal and APIs


Specifications | MSDS | Literature and Reviews


4-Hydroxy-2-(trifluoromethyl)benzoic acid (CAS number 320-32-1) has hydroxyl, carboxylic acid and trifluoromethyl functional groups on the benzene ring. The carboxylic acid and hydroxyl groups are in the para-position, enabling it to synthesis linear molecules. Polyesters with segments of 4-hydroxy-2-(trifluoromethyl)benzoic acid self-assemble to form spherulite crystals for the fabrication of optical vortex beam generator. 4-Hydroxy-2-(trifluoromethyl)benzoic acid reacts with alkylated acyl chloride for the synthesis of smectic C liquid crystals.

Additionally, 4-hydroxy-2-(trifluoromethyl)benzoic acid can be attached to molecular scaffolds, such as benzofuran derivatives, through esterification and amide synthesis for producing active pharmaceutical ingredients (APIs) as antitubercular agents.

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated building block

Fluorinated benzoic acid building block

for drug discovery, liquid crystals, and biochemistry research

Worldwide shipping for 320-32-1

Worldwide shipping

Quick and reliable shipping

High purity

High purity

>98% High purity

General Information


CAS Number 320-32-1
Chemical Formula C8H5F3O3
Full Name 4-Hydroxy-2-(trifluoromethyl)benzoic acid
Molecular Weight 206.12 g/mol
Synonyms α,α,α-Trifluoro-4-hydroxy-o-toluic acid, 4-Carboxy-3-(trifluoromethyl)phenol
Classification / Family Fluorinated building blocks, Benzoic acid building blocks, Phenol building blocks, Heterocycles, Liquid crystals, APIs

Chemical Structure


4-Hydroxy-2-(trifluoromethyl)benzoic acid chemical structure, CAS 320-32-1.
4-Hydroxy-2-(trifluoromethyl)benzoic acid chemical structure, CAS 320-32-1

Product Details


Purity 98%
Melting Point Tm = 159 °C – 161 °C
Appearance White powder

MSDS Documentation


4-Hydroxy-2-(trifluoromethyl)benzoic acid4-Hydroxy-2-(trifluoromethyl)benzoic acid MSDS Sheet

Literature and Reviews


  1. Design, in-silico study and biological evaluation of newly synthesized 3-chlorobenzofuran congeners as antitubercular agents, M. Abdullah et al., Arab. J. Chem., 14, 103034(2021); DOI: 10.1016/j.arabjc.2021.103034.
  2. Optical vortices enabled by structural vortices, Y. Liu et al., arXiv:2306.03359(2023); DOI: 10.48550/arXiv.2306.03359.
  3. Comprehensive review on coumarins: molecules of potential chemical and pharmacological interest, K. Kumar et al., J Chem Pharm Res, 7(9), 67–81(2015); ISSN : 0975-7384.

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