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4-Fluorobenzenesulfonamide

CAS Number 402-46-0

Fluorinated Building Blocks, Materials, Monomers


Product Code B2461-10g
Price £65 ex. VAT

A fluorinated sulfonamide building block

Used as a synthesis intermediate for APIs and bioimaging fluorophores


Specifications | MSDS | Literature and Reviews


4-Fluorobenzenesulfonamide (CAS number 402-46-0) is a para-substituted fluorinated benzenesulfonamide. 4-Fluorobenzenesulfonamide consists of a sulfonyl group terminated by an amine, enabling functionalisation through nucleophilic substitution. For instance, 4-fluorobenzenesulfonamide reacts with benzaldehyde to form (E)-N-(4-fluorobenzylidene)-4-fluorobenzenesulfonamide as an antimicrobial. A potential anti-tumour drug bis(dithiocabinmato)-platinum(II) can be synthesised from 4-fluorobenzenesulfonamide with carbon disulfide and platinum complex. PI3K/mTOR dual inhibitors are designed and synthesised from 4-fluorobenzenesulfonamide, showing half maximal inhibitory concentration up to 2.88 ± 0.58 µM.

Other than pharmaceutical applications, 4-fluorobenzenesulfonamide has been exploited to functionalise rhodamines for systematic tuning of the equilibrium of spirocyclisation for high resolution bioimaging.

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated building block

Fluorinated sulfonamide building block

For drug discovery, medicinal chemistry and bioimaging research

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High purity 402-46-0

High purity

>98% High purity

General Information


CAS Number 402-46-0
Chemical Formula C6H6FNO2S
Full Name 4-Fluorobenzenesulfonamide
Molecular Weight 175.18 g/mol
Synonyms p-Fluorobenzenesulfonamide, 4-Fluorobenzene-1-sulfonamide
Classification / Family Fluorinated building block, Sulfonamides, APIs, Fluorophores

Chemical Structure


4-Fluorobenzenesulfonamide chemical structure, CAS 402-46-0.
4-Fluorobenzenesulfonamide chemical structure, CAS 402-46-0

Product Details


Purity 98%
Melting Point Tm = 124 °C – 127 °C
Appearance White powder

MSDS Documentation


4-Fluorobenzenesulfonamide4-Fluorobenzenesulfonamide MSDS Sheet

Literature and Reviews


  1. Systematic tuning of rhodamine spirocyclization for super-resolution microscopy, N. Lardon et al., J. Am. Chem. Soc., 143(36), 14592–14600(2021); DOI: 10.1021/jacs.1c05004.
  2. Syntheses, crystal structure and spectroscopic characterization of new platinum(II) dithiocarbimato complexes, R. Amim et al., Polyhedron, 27, 1891–1897(2008); DOI: 10.1016/j.poly.2008.02.030.
  3. Design, synthesis and biological evaluation of novel phenylsulfonylurea derivatives as PI3K/mTOR dual inhibitors, B. Zhao et al., Molecules, 23, 1553(2018); DOI: 10.3390/molecules23071553.
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