4-Bromo-8-fluoroquinoline

CAS Number 927800-38-2

Chemistry Building Blocks, Fluorinated Building Blocks, Heterocyclic Building Blocks, Monomers

4-Bromo-8-fluoroquinoline CAS 927800-38-2

A fluorinated heterocyclic building block

Used as a synthesis intermediate for APIs, DSSCs and sensors

Overview
Related Products

Bearing both bromo- and fluoro-substituents, 4-bromo-8-fluoroquinoline (CAS number 927800-38-2) is another useful intermediate for the preparation of active quinoline elements in drug discovery. Fluoroquinolines are typically used as active pharmaceutical ingredients (APIs) such as antibiotics. Additionally, 8-fluoroquinoline derivatives have also proven effective against insects, nematodes, and mites as agricultural chemicals. 4-Bromo-8-fluoroquinoline has multiple functional groups, which is an ideal candidate in substrate scopes for synthetic methodology studies.

This brominated building block can also be used as an end-capping material to extend the chromophore size of other chemicals through Pd-catalysed cross-coupling reactions. For example, it can enhance the fluorescent signal of cyclobarbital molecularly imprinted polymer for electrochemical sensing.

Multiple functional groups

For facile synthesis

Fluorinated quinoline building block

For drug discoveries, dyes, and solar cells

Worldwide shipping

Quick and reliable shipping

High purity

>98% High purity

General Information

CAS Number	927800-38-2
Chemical Formula	C₉H₅BrFN
Full Name	4-Bromo-8-fluoroquinoline
Molecular Weight	226.05 g/mol
Synonyms	N/A
Classification / Family	Quinoline derivatives, Fluorinated building blocks, Heterocyclic building block, Dyes, DSSCs, Sensors, APIs

Chemical Structure

Product Details

Purity	>98%
Melting Point	T_m = 112 °C – 113 °C
Appearance	White to light yellow powder/crystal

MSDS Documentation

4-Bromo-8-fluoroquinoline MSDS Sheet

Literature and Reviews

Tandem photoelectrochemical and photoredox catalysis for efficient and selective aryl halides functionalization by solar energy, Y.-J. Chen et al., Matter, 4, 2354–2366(2021); DOI: 10.1016/j.matt.2021.05.004.
Bio-inspired imprinting materials for biomedical applications, H. Chen et al., Adv. Sci., 9, 2202038(2022); DOI: 10.1002/advs.202202038.
Fluorinated quinolines: synthesis, properties and applications, G. Lipunova et al., Fluorine in Heterocyclic Chemistry, 2, 59-109(2015); DOI: 10.1007/978-3-319-04435-4_2.
Photoinduced palladium-catalysed Negishi cross-couplings enabled by the visible-light absorption of palladium–zinc complexes, I. Abdiaj et al., Angew. Chem. Int. Ed., 57, 13231–13236(2018); DOI: 10.1002/anie.201808654.
Strategies to control human health risks arising from antibiotics in the environment: molecular modification of QNs for enhanced plant-microbial synergistic degradation, P. Sun et al., Int. J. Environ. Res. Public Health, 18, 10610(2021); DOI: 10.3390/ijerph182010610.

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