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Product Code B1891-LT-500mg
Price $169 ex. VAT

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A fluorinated heterocyclic building block

Used as a synthesis intermediate for APIs, DSSCs and sensors

Bearing both bromo- and fluoro-substituents, 4-bromo-8-fluoroquinoline (CAS number 927800-38-2) is another useful intermediate for the preparation of active quinoline elements in drug discovery. Fluoroquinolines are typically used as active pharmaceutical ingredients (APIs) such as antibiotics. Additionally, 8-fluoroquinoline derivatives have also proven effective against insects, nematodes, and mites as agricultural chemicals. 4-Bromo-8-fluoroquinoline has multiple functional groups, which is an ideal candidate in substrate scopes for synthetic methodology studies.

This brominated building block can also be used as an end-capping material to extend the chromophore size of other chemicals through Pd-catalysed cross-coupling reactions. For example, it can enhance the fluorescent signal of cyclobarbital molecularly imprinted polymer for electrochemical sensing.

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated building block

Fluorinated quinoline building block

For drug discoveries, dyes, and solar cells

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High purity 927800-38-2

High purity

>98% High purity

General Information

CAS Number 927800-38-2
Chemical Formula C9H5BrFN
Full Name 4-Bromo-8-fluoroquinoline
Molecular Weight 226.05 g/mol
Synonyms N/A
Classification / Family Quinoline derivatives, Fluorinated building blocks, Heterocyclic building block, Dyes, DSSCs, Sensors, APIs

Chemical Structure

4-Bromo-8-fluoroquinoline chemical structure, CAS 927800-38-2
4-Bromo-8-fluoroquinoline chemical structure, CAS 927800-38-2

Product Details

Purity >98%
Melting Point Tm = 112 °C – 113 °C
Appearance White to light yellow powder/crystal

MSDS Documentation

4-Bromo-8-fluoroquinoline4-Bromo-8-fluoroquinoline MSDS Sheet

Literature and Reviews

  1. Tandem photoelectrochemical and photoredox catalysis for efficient and selective aryl halides functionalization by solar energy, Y.-J. Chen et al., Matter, 4, 2354–2366(2021); DOI: 10.1016/j.matt.2021.05.004.
  2. Bio-inspired imprinting materials for biomedical applications, H. Chen et al., Adv. Sci., 9, 2202038(2022); DOI: 10.1002/advs.202202038.
  3. Fluorinated quinolines: synthesis, properties and applications, G. Lipunova et al., Fluorine in Heterocyclic Chemistry, 2, 59-109(2015); DOI: 10.1007/978-3-319-04435-4_2.
  4. Photoinduced palladium-catalysed Negishi cross-couplings enabled by the visible-light absorption of palladium–zinc complexes, I. Abdiaj et al., Angew. Chem. Int. Ed., 57, 13231–13236(2018); DOI: 10.1002/anie.201808654.
  5. Strategies to control human health risks arising from antibiotics in the environment: molecular modification of QNs for enhanced plant-microbial synergistic degradation, P. Sun et al., Int. J. Environ. Res. Public Health, 18, 10610(2021); DOI: 10.3390/ijerph182010610.

To the best of our knowledge the information provided here is accurate. The values provided are typical at the time of manufacture and may vary over time and from batch to batch. Products may have minor cosmetic differences (e.g. to the branding) compared to the photos on our website. All products are for laboratory and research and development use only.

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