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3-Fluoro-2-methylbenzoic acid

CAS Number 699-90-1

Chemistry Building Blocks, Fluorinated Building Blocks, Monomers


Product Code B2661-5g
Price $113 ex. VAT

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A fluorinated benzoic acid building block

Used as a synthesis intermediate for APIs and liquid crystals


3-Fluoro-2-methylbenzoic acid (CAS number 699-90-1) is derived from methylbenzoic acid, also known as ortho-toluic acid. Acetoxy-methylbenzoic anhydride is synthesised from 3-fluoro-2-methylbenzoic acid, demonstrating antibiotic activity with minimum inhibitory concentration (MIC) of 500–1000 μg/mL. Diarylmethanes, which are novel building blocks for sodium-glucose transporter 2 (SGLT2) inhibitors can be obtained from 3-fluoro-2-methylbenzoic acid through Friedel-Crafts acylation, followed by a reduction reaction.

The positioning of the carboxylic acid and fluoride at the meta-position renders 3-fluoro-2-methylbenzoic acid a structural scaffold for bent-core liquid crystals.

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated building block

Fluorinated benzoic acid building block

For drug discovery, liquid crystals and biochemistry research

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High purity 699-90-1

High purity

>98% High purity

General Information

CAS Number 699-90-1
Chemical Formula C8H7FO2
Full Name 3-Fluoro-2-methylbenzoic acid
Molecular Weight 154.14 g/mol
Synonyms 3-Fluoro-o-toluic acid
Classification / Family Fluorinated building blocks, Benzoic acid derivatives, APIs, Liquid crystals

Chemical Structure

3-Fluoro-2-methylbenzoic acid chemical structure, CAS 699-90-1.
3-Fluoro-2-methylbenzoic acid chemical structure, CAS 699-90-1

Product Details

Purity 98%
Melting Point Tm = 158 °C – 160 °C
Appearance White powder

MSDS Documentation

3-Fluoro-2-methylbenzoic acid3-Fluoro-2-methylbenzoic acid MSDS Sheet

Literature and Reviews

  1. Regioselective nitration of 3-fluoro-2-substituted benzoic acids, K. Hurth et al., Tetrahedron Lett., 56(22), 2860–2862(2015); DOI: 10.1016/j.tetlet.2015.04.057.
  2. Synthesis, spectroscopic characterization, single-crystal structure, Hirshfeld surface analysis, and antimicrobial studies of 3-acetoxy-2-methylbenzoic anhydride, Ş. Çakmak et al., ACS Omega, 7, 17192–17201(2022); DOI: 10.1021/acsomega.2c00879.
  3. New synthesis of diarylmethanes, key building block for SGLT2 inhibitors, M. Seki et al., ACS Omega, 8, 17288–17295(2023); DOI: 10.1021/acsomega.3c01972.
  4. Nematic phase of polar unsymmetrical bent-core molecules, S. Kaur et al., ChemPhysChem, 24, e202300133(2023); DOI: 10.1002/cphc.202300133.

To the best of our knowledge the information provided here is accurate. The values provided are typical at the time of manufacture and may vary over time and from batch to batch. Products may have minor cosmetic differences (e.g. to the branding) compared to the photos on our website. All products are for laboratory and research and development use only.

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