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Product Code B2911-2g
Price £65 ex. VAT

A fluorinated aniline building block

For the synthesis of APIs for inflammatory and antiviral treatments

Specifications | MSDS | Literature and Reviews

3-Chloro-5-fluoroaniline (CAS number 4863-91-6) is an aniline derivative bearing chlorine and fluorine substituents at the 3- and 5-positions. 3-Chloro-5-fluoroaniline is extensively used to synthesise active pharmaceutical ingredients (APIs), particularly antiviral compounds targeting the influenza A H1N1 virus. 3-Chloro-5-fluoroaniline can be readily incorporated into molecular scaffolds through reductive amination and nucleophilic substitution. 3-Chloro-5-fluoroaniline is also involved in the synthesis of glucocorticoid receptor agonist for inflammation treatments. The synthesis of the tetrahydroquinoline-based glucocorticoid receptor agonist commences with 3-chloro-5-fluoroaniline reacting with acetone and iodine under Skraup reaction.

The presence of chlorine and fluorine substituents in 3-chloro-5-fluoroaniline enables further functionalisation, such as palladium-catalysed carbon-carbon coupling and nucleophilic aromatic substitution.

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated building block

Fluorinated aniline building block

For drug discovery, medicinal chemistry and biochemistry research

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High purity 4863-91-6

High purity

>97% High purity

General Information

CAS Number 4863-91-6
Chemical Formula C6H5ClFN
Full Name 3-Chloro-5-fluoroaniline
Molecular Weight 145.56 g/mol
Synonyms 3-Chloro-5-fluorobenzenamine
Classification / Family Fluorinated building blocks, Aniline building blocks, APIs

Chemical Structure

3-Chloro-5-fluoroaniline chemical structure, CAS 4863-91-6.
3-Chloro-5-fluoroaniline chemical structure, CAS 4863-91-6

Product Details

Purity 97%
Boiling Point Tb = 226 °C at 760 mmHg
Relative Density 1.45 g/mL
Appearance Clear liquid

MSDS Documentation

3-Chloro-5-fluoroaniline3-Chloro-5-fluoroaniline MSDS Sheet

Literature and Reviews

  1. Aniline-based inhibitors of influenza H1N1 virus acting on hemagglutinin-mediated fusion, R. Leiva et al., J. Med. Chem., 61, 98–118(2018); DOI: 10.1021/acs.jmedchem.7b00908.
  2. Discovery of orally available tetrahydroquinoline-based glucocorticoid receptor agonists, Bioorg. Med. Chem. Lett., 21, 1697–1700(2011); DOI: 10.1016/j.bmcl.2011.01.093.
  3. Species-selective pyrimidineamine inhibitors of Trypanosoma brucei S-adenosylmethionine decarboxylase, O. Volkov et al., J. Med. Chem., 61(3); DOI: 10.1021/acs.jmedchem.7b01654.

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