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Ethyl (4-fluorobenzoyl)acetate

CAS Number 1999-00-4

Chemistry Building Blocks, Fluorinated Building Blocks, Monomers


Product Code B1841-5g
Price $138 ex. VAT

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A fluorinated ketoester derived building block

Used as a ligand in catalytic reaction and synthetic intermediate of pyrimidine for OLEDs, semiconductors and DSSCs


Ethyl (4-fluorobenzoyl)acetate (p-EFBA), CAS number 1999-00-4, the analogue of β-Ketoester, is typically used as a ligand for improving stereoselectivity of catalytic reactions for great chelating ability to metal centres. Ethyl (4-fluorobenzoyl)acetate is an ideal starting material for synthesizing pyrimidine derivatives via Pinner pyrimidine reaction with amidine/guanidine. The iridium complexes formed by those pyrimidine derivatives are used for long lasting blue phosphorescent organic light-emitting diodes (PhOLEDs). The self-assembled monomer layer of pyrimidine derivatives can engineer the interfacial band of MoS2 and gold for enhanced device performance in thin film transistors.

Ethyl (4-fluorobenzoyl)acetate can be obtained by the reaction of 4-fluoroacetophenone with diethyl carbonate and sodium hydride as the base in great yield.

Multiple functional groups

Multiple functional groups

For facile synthesis

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High purity 1999-00-4

High purity

>97% High purity

Fluorinated building block

Fluorinated phenyloxopropanoate building block

For drug discoveries, dyes, and semiconductors

General Information

CAS Number 1999-00-4
Chemical Formula C11H11FO3
Full Name Ethyl 3-(4-Fluorophenyl)-3-Oxopropanoate
Molecular Weight 210.20 g/mol
Synonyms (4-Fluorobenzoyl)acetic acid ethyl ester, 3-(4-Fluorophenyl)-3-oxopropionic acid ethyl ester
Classification / Family Ketoester derivatives, Fluorinated building blocks, Semiconductor synthesis intermediates, Dyes

Chemical Structure

Ethyl (4-fluorobenzoyl)acetate chemical structure, CAS1999-00-4
Ethyl (4-fluorobenzoyl)acetate chemical structure, CAS 1999-00-4

Product Details

Purity >97%
Boiling Point Tb = 355 °C – 360 °C at 760 mmHg
Relative Density 1.174 g/mL at 25 °C
Appearance Slightly yellow liquid

MSDS Documentation

3,3-Difluoroazetidine hydrochlorideEthyl (4-fluorobenzoyl)acetate MSDS Sheet

Literature and Reviews

  1. Interfacial band engineering of MoS2/Gold interfaces using pyrimidine-containing self-assembled monolayers: toward contact-resistance-free bottom-contacts, A. Matković et al., Adv. Electron. Mater., 6, 2000110(2020); DOI: 10.1002/aelm.202000110.
  2. Anomalously long-lasting blue PhOLED feathuring phenyl-pyrimidine cyclomealated iridium emitter, M Sarma et al., Chem, 3, 461–476(2017); DOI: 10.1016/j.chempr.2017.08.001.
  3. Recent progress of pyrimidine derivatives for high-performance organic light-emitting devices, R. Komatsu et al., J. photonics Energy, 8(3), 032108(2018); DOI: 10.1117/1.JPE.8.032108.
  4. Ligand-functionalized Pt nanoparticles as asymmetric heterogeneous catalysts: molecular reaction control by ligand-reactant interactions, A. Šulce et al., Catal. Sci. Technol., 8, 6062-6075(2018); DOI: 10.1039/C8CY01836G.
  5. The long-lasting blues: a new record for phosphorescent organic light-emitting diodes, K. Kirlikovali et al., Chem, 3, 383–389(2017); DOI: 10.1016/j.chempr.2017.08.013.

To the best of our knowledge the information provided here is accurate. The values provided are typical at the time of manufacture and may vary over time and from batch to batch. Products may have minor cosmetic differences (e.g. to the branding) compared to the photos on our website. All products are for laboratory and research and development use only.

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